Jérôme C. Martin
University of Nantes
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Publications 35
#1Mathieu UzzanH-Index: 7
#1Mathieu Uzzan (Beaujon Hospital)H-Index: 4
Last. Yoram Bouhnik (Beaujon Hospital)H-Index: 59
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Consistent observations report increased severity of SARS-CoV-2 infection in overweight men with cardiovascular factors As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection SARS-CoV2 presents the ability to infect epithelial cells of the respiratory tract as well as the intestinal tract Sev...
1 CitationsSource
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can...
23 CitationsSource
#1Mathieu UzzanH-Index: 7
#2Jérôme C. MartinH-Index: 8
Last. William E. O'GormanH-Index: 13
view all 27 authors...
#1Ahmed Abidi (University of Nantes)H-Index: 5
#2Thomas Laurent (University of Nantes)
Last. Jérôme C. Martin (University of Nantes)H-Index: 8
view all 10 authors...
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that lack antigen-specific receptors and exhibit innate effector functions such as cytokine production that play an important role in immediate responses to pathogens especially at mucosal sites. Mouse and human ILC subsets have been extensively characterized in various tissues and in blood. In this study, we present the first characterization of ILCs and ILC subsets in rat gut and secondary lymphoid organs using flow cytometry and sin...
#1Alexis Broquet (University of Nantes)H-Index: 12
#2Anissa Besbes (University of Nantes)H-Index: 2
Last. Karim Asehnoune (University of Nantes)H-Index: 27
view all 9 authors...
Abstract Background Interleukin (IL)-22 is a cytokine involved in tissue protection and repair following lung pathologies. Interferon (IFN)-λ cytokines displayed similar properties during viral infection and a synergy of action between these two players has been documented in the intestine. We hypothesize that during Pseudomonas aeruginosa challenge, IL-22 up-regulates IFN-λ and that IFN-λ exhibits protective functions during Pseudomonas aeruginosa acute pneumonia model in mice. Methods Using an...
2 CitationsSource
#1Lyssia BelarifH-Index: 3
#2Richard DangerH-Index: 17
Last. Nicolas PoirierH-Index: 18
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: It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC), in humans. According to an analysis of up to 500 patients with IBD and 100 controls, we report that key transcripts of the IL-7 receptor (IL-7R) pathway are accumulated in inflamed colon tissues of severe CD and UC patients not responding to either immunosuppressive/corticosteroid, anti-TNF, or anti...
6 CitationsSource
#1Aurélie Fantou (University of Nantes)H-Index: 1
#2Jérôme C. Martin (University of Nantes)H-Index: 8
Last. Régis Josien (University of Nantes)H-Index: 38
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#1Aurélie Fantou (University of Nantes)H-Index: 1
#2Ahmed Abidi (University of Nantes)H-Index: 5
Last. Régis Josien (University of Nantes)H-Index: 38
view all 9 authors...
#1Jason Ossart (University of Nantes)H-Index: 2
#2Anne MoreauH-Index: 42
Last. Carole Guillonneau (University of Nantes)H-Index: 2
view all 15 authors...
Autoimmune regulator (AIRE) deficiency in humans induces a life-threatening generalized autoimmune disease called autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED), and no curative treatments are available. Several models of AIRE-deficient mice have been generated, and although they have been useful in understanding the role of AIRE in central tolerance, they do not reproduce accurately the APECED symptoms, and thus there is still a need for an animal model displaying APECE...