Cristina M. Ramírez
Yale University
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Publications 56
#1Xinbo Zhang (Yale University)H-Index: 10
#2Cristina M. Ramírez (Yale University)H-Index: 24
Last. William C. Sessa (Yale University)H-Index: 104
view all 11 authors...
OBJECTIVE: Endothelial Cav-1 (caveolin-1) expression plays a relevant role during atherogenesis by controlling NO production, vascular inflammation, LDL (low-density lipoprotein) transcytosis, and extracellular matrix remodeling. Additional studies have identified cholesterol-rich membrane domains as important regulators of autophagy by recruiting ATGs (autophagy-related proteins) to the plasma membrane. Here, we investigate how the expression of Cav-1 in the aortic endothelium influences autoph...
#1Cristina M. Ramírez (Yale University)H-Index: 24
#2Xinbo Zhang (Yale University)H-Index: 10
Last. Carlos Fernández-Hernando (Yale University)H-Index: 46
view all 21 authors...
Background: Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated that absence of c...
1 CitationsSource
#1Noemi RotllanH-Index: 26
#2Xinbo ZhangH-Index: 10
view all 6 authors...
#1Jung Dae Kim (Yale University)H-Index: 8
#2Chitoku Toda (Yale University)H-Index: 14
Last. Sabrina DianoH-Index: 49
view all 5 authors...
The Lin28a/ Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral tissues. Its expression is positively correlated with positive energy balance, suggesting a potential central role for Lin28a in metabolism regulation. Thus, we targeted the hypothalamic ventromedial nucleus (VMH) to selectively overexpress ( Lin28aKI VMH ) or ...
5 CitationsSource
#1Peter Willeit (University of Cambridge)H-Index: 39
#2Philipp Skroblin ('KCL': King's College London)H-Index: 14
Last. Manuel Mayr ('KCL': King's College London)H-Index: 67
view all 19 authors...
MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown. We therefore measured circulating miR-122 in the prospective population-based Bruneck Study ( n =810; survey year: 1995). Circulating miR-122 was associated with prevalent insulin resistance, obesity, metabolic syndrome, type-2 diabetes, and an adverse lipid profile. Among 92 plasma proteins and 135 lipid subspecies quantified wi...
54 CitationsSource
#1Jan R. Kraehling (Yale University)H-Index: 6
#2John H. Chidlow (Yale University)H-Index: 13
Last. William C. Sessa (Yale University)H-Index: 104
view all 24 authors...
Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in the vessel wall.
28 CitationsSource
#1Peter Willeit ('KCL': King's College London)H-Index: 39
#2Xiaoke Yin ('KCL': King's College London)H-Index: 34
Last. Manuel Mayr ('KCL': King's College London)H-Index: 67
view all 17 authors...
1 CitationsSource
#1Binod Aryal (Yale University)H-Index: 10
#2Noemi Rotllan (Yale University)H-Index: 26
Last. Carlos Fernández-Hernando (Yale University)H-Index: 46
view all 14 authors...
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report that angiopoietin-like protein 4 (ANGPTL4) is the most highly upregulated gene in foamy macrophages and it's absence in haematopoietic cells results in larger atherosclerotic plaques, characterized by bigger necrotic core areas and increased macrophage apoptosis. Furthermore, hyperlipidemic mice deficient in haematopoietic ANGPTL4 have higher...
20 CitationsSource
#1Leigh Goedeke (Yale University)H-Index: 18
#2Noemi Rotllan (Yale University)H-Index: 26
Last. Carlos Fernández-Hernando (Yale University)H-Index: 46
view all 12 authors...
Abstract Rationale Recently, there has been significant interest in the therapeutic administration of miRNA mimics and inhibitors to treat cardiovascular disease. In particular, miR-27b has emerged as a regulatory hub in cholesterol and lipid metabolism and potential therapeutic target for treating atherosclerosis. Despite this, the impact of miR-27b on lipid levels in vivo remains to be determined. As such, here we set out to further characterize the role of miR-27b in regulating cholesterol me...
28 CitationsSource