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Cristina M. Ramírez
Yale University
33Publications
21H-index
1,833Citations
Publications 33
Newest
Published on Jun 3, 2019in Circulation23.05
Cristina M. Ramírez21
Estimated H-index: 21
(Yale University),
Xinbo Zhang9
Estimated H-index: 9
(Yale University)
+ 18 AuthorsVictoria Ulrich2
Estimated H-index: 2
(Yale University)
Background: Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated that absence of c...
Published on Jun 1, 2018in Atherosclerosis Supplements2.35
Noemi Rotllan13
Estimated H-index: 13
,
Xinbo Zhang9
Estimated H-index: 9
+ 3 AuthorsCarlos Fernández-Hernando45
Estimated H-index: 45
Published on Aug 1, 2017in Diabetes7.20
Jung Dae Kim8
Estimated H-index: 8
(Yale University),
Chitoku Toda14
Estimated H-index: 14
(Yale University)
+ 2 AuthorsSabrina Diano48
Estimated H-index: 48
The Lin28a/ Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral tissues. Its expression is positively correlated with positive energy balance, suggesting a potential central role for Lin28a in metabolism regulation. Thus, we targeted the hypothalamic ventromedial nucleus (VMH) to selectively overexpress ( Lin28aKI VMH ) or ...
Published on Feb 1, 2017in Diabetes7.20
Peter Willeit37
Estimated H-index: 37
(University of Cambridge),
Philipp Skroblin13
Estimated H-index: 13
('KCL': King's College London)
+ 16 AuthorsLeigh Goedeke17
Estimated H-index: 17
(Yale University)
MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is unknown. We therefore measured circulating miR-122 in the prospective population-based Bruneck Study ( n =810; survey year: 1995). Circulating miR-122 was associated with prevalent insulin resistance, obesity, metabolic syndrome, type-2 diabetes, and an adverse lipid profile. Among 92 plasma proteins and 135 lipid subspecies quantified wi...
Published on Dec 1, 2016in Nature Communications11.88
Jan R. Kraehling5
Estimated H-index: 5
(Yale University),
John H. Chidlow13
Estimated H-index: 13
(Yale University)
+ 21 AuthorsBo Tao1
Estimated H-index: 1
(Yale University)
Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in the vessel wall.
Published on Nov 1, 2016in Nature Communications11.88
Binod Aryal9
Estimated H-index: 9
,
Noemi Rotllan21
Estimated H-index: 21
+ 11 AuthorsNikhil Warrier3
Estimated H-index: 3
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report that angiopoietin-like protein 4 (ANGPTL4) is the most highly upregulated gene in foamy macrophages and it's absence in haematopoietic cells results in larger atherosclerotic plaques, characterized by bigger necrotic core areas and increased macrophage apoptosis. Furthermore, hyperlipidemic mice deficient in haematopoietic ANGPTL4 have higher...
Published on Sep 1, 2016in Atherosclerosis4.25
Peter Willeit37
Estimated H-index: 37
('KCL': King's College London),
Xiaoke Yin32
Estimated H-index: 32
('KCL': King's College London)
+ 14 AuthorsEnzo Bonora57
Estimated H-index: 57
Published on Dec 1, 2015in Atherosclerosis4.25
Leigh Goedeke17
Estimated H-index: 17
(Yale University),
Noemi Rotllan21
Estimated H-index: 21
(Yale University)
+ 9 AuthorsÁngel Baldán18
Estimated H-index: 18
(SLU: Saint Louis University)
Abstract Rationale Recently, there has been significant interest in the therapeutic administration of miRNA mimics and inhibitors to treat cardiovascular disease. In particular, miR-27b has emerged as a regulatory hub in cholesterol and lipid metabolism and potential therapeutic target for treating atherosclerosis. Despite this, the impact of miR-27b on lipid levels in vivo remains to be determined. As such, here we set out to further characterize the role of miR-27b in regulating cholesterol me...
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