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Raffay Khan
Columbia University
43Publications
11H-index
547Citations
Publications 43
Newest
#1Raffay KhanH-Index: 11
#2Yan Lin (Qiqihar Medical University)H-Index: 1
Last.Sunichi Homma (Columbia University)H-Index: 2
view all 13 authors...
Hearts utilize fatty acids as a primary source of energy. The sources of those lipids include free fatty acids and lipoprotein triglycerides. Deletion of the primary triglyceride-hydrolyzing enzyme lipoprotein lipase (LPL) leads to cardiac dysfunction. Whether heart LPL-knockout (hLPL0) mice are compromised due a deficiency in energetic substrates is unknown. To test whether alternative sources of energy will prevent cardiac dysfunction in hLPL0 mice, two different models were used to supply non...
#1Konstantinos Drosatos (Columbia University)H-Index: 20
#2Raffay KhanH-Index: 11
Last.Ira J. GoldbergH-Index: 71
view all 9 authors...
Impaired cardiac contractility contributes to the hypotension and increased mortality that occur with sepsis1. A possible cause of sepsis-mediated cardiac dysfunction is reduced energy production due in part to compromised fatty acid oxidation (FAO)2-5 and glucose catabolism3, 6. Thus, it is likely that sepsis compromises cardiac energy production, which might be the major cause of cardiac dysfunction. Alternatively, sepsis induces the production of inflammatory cytokines, such as tumor necrosis...
#1Konstantinos Drosatos (Columbia University)H-Index: 20
#2Raffay Khan (Columbia University)H-Index: 11
Last.Ira J. Goldberg (Columbia University)H-Index: 71
view all 9 authors...
Background— Cardiac dysfunction with sepsis is associated with both inflammation and reduced fatty acid oxidation. We hypothesized that energy deprivation accounts for sepsis-related cardiac dysfunction. Methods and Results— Escherichia coli lipopolysaccharide (LPS) administered to C57BL/6 mice (wild type) induced cardiac dysfunction and reduced fatty acid oxidation and mRNA levels of peroxisome proliferator–activated receptor (PPAR)-α and its downstream targets within 6–8 hours. Transgenic mice...
#1Konstantinos Drosatos (Columbia University)H-Index: 20
#2Raffay Khan (Columbia University)H-Index: 11
Last.Ira J. Goldberg (Columbia University)H-Index: 71
view all 9 authors...
Background—Cardiac dysfunction with sepsis is associated with both inflammation and reduced fatty acid oxidation. We hypothesized that energy deprivation accounts for sepsis-related cardiac dysfunction. Methods and Results—Escherichia coli lipopolysaccharide (LPS) administered to C57BL/6 mice (wild type) induced cardiac dysfunction and reduced fatty acid oxidation and mRNA levels of peroxisome proliferator–activated receptor (PPAR)-α and its downstream targets within 6–8 hours. Transgenic mice i...
#1Konstantinos Drosatos (Columbia University)H-Index: 20
#2Raffay Khan (Columbia University)H-Index: 11
Last.Ira J. Goldberg (Columbia University)H-Index: 71
view all 9 authors...
Background —Cardiac dysfunction with sepsis is associated with both inflammation and reduced fatty acid oxidation (FAO). We hypothesized that energy deprivation accounts for sepsis-related cardiac dysfunction. Methods and Results —E. coli lipopolysaccharide (LPS) administered to C57BL/6 mice (WT) induced cardiac dysfunction and reduced FAO and mRNA levels of peroxisome proliferator-activated receptor (PPAR) α and its downstream targets within 6-8h. Transgenic mice in which cardiomyocyte-specific...
Fish oil (FO) supplementation may improve cardiac function in some patients with heart failure, especially those with diabetes. To determine why this occurs, we studied the effects of FO in mice with heart failure due either to transgenic expression of the lipid uptake protein, acyl CoA synthetase 1 (ACS1) or overexpression of the transcription factor peroxisomal proliferator activated receptor (PPAR)γ via the cardiac specific myosin heavy chain (MHC) promoter. ACS1 mice and control littermates ...
#1Konstantinos Drosatos (Columbia University)H-Index: 20
#2Raffay Khan (Columbia University)H-Index: 11
Last.Ira J. Goldberg (Columbia University)H-Index: 71
view all 6 authors...
Septic cardiac dysfunction has been attributed to either inflammation or suppression of fatty acid oxidation (FAO). We hypothesized that energy deprivation accounts for cardiac dysfunction in lipopolysaccharide (LPS)-induced sepsis. LPS compromised cardiac function, increased cardiac inflammatory markers (interleukin (IL)-1α, IL-6 and tumor necrosis factor (TNF)α) mRNA, and reduced FAO, ATP and FAO-related gene expression: Peroxisome proliferator activating receptor (PPAR)α, cluster of different...
#1Li LiuH-Index: 6
#2Shuiqing YuH-Index: 14
Last.Ira J. GoldbergH-Index: 71
view all 8 authors...
Accumulation of excess lipids is associated with heart failure. The effects of transgenic expression of diacylglycerol acyl transferase 1 (DGAT1) in cardiomyocytes is controversial. We explored whether mice expressing DGAT1 via the myosin heavy chain (MHC) promoter develop heart dysfunction with aging or after crossing with mice over expressing peroxisome proliferator-activated receptor γ (PPARγ) in the heart. MHC-DGAT1 transgenic mice had increased heart triglyceride but no evidence of heart dy...
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