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Eduardo A. Silva
University of California, Davis
Self-healing hydrogelsVascular endothelial growth factorAngiogenesisTherapeutic angiogenesisBiology
86Publications
22H-index
3,081Citations
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Publications 83
Newest
#1R. Warren Sands (Harvard University)H-Index: 4
#2Catia S. Verbeke (Harvard University)H-Index: 9
Last. David J. Mooney (Harvard University)H-Index: 121
view all 7 authors...
BACKGROUND: Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic inflammation. Dendritic cells (DC) are key regulators of T-cell fate, and biomaterials that recruit and program DC locally can direct T-cell effector responses. We hypothesized that a biomaterial that recruited and programmed dendritic cells toward a tolerogenic phenotype could enrich r...
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#1Kevin T. Campbell (UC Davis: University of California, Davis)H-Index: 4
#2Kajetan Wysoczynski (UC Davis: University of California, Davis)
Last. Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 22
view all 4 authors...
Hydrogel systems are an appealing class of therapeutic delivery vehicles, though it can be challenging to design hydrogels that maintain desired spatiotemporal presentation of therapeutic cargo. In this work, we propose a different approach in which computational tools are developed that creates a theoretical representation of the hydrogel polymer network to design hydrogels with predefined mesh properties critical for controlling therapeutic delivery. We postulated and confirmed that the comput...
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#1A.L. Torres (University of Porto)H-Index: 2
#1Ana Luísa Torres (University of Porto)H-Index: 2
Last. Cristina C. Barrias (University of Porto)H-Index: 26
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Abstract Successful strategies to promote neovascularization of ischemic tissues are still scarce, being a central priority in regenerative medicine. Microparticles harboring primitive vascular beds are appealing cell delivery candidates for minimally-invasive therapeutic vascularization. However, dynamic cellular alterations associated with in vitro vascular morphogenesis are still elusive. Here, bioengineered microgels guided the assembly of entrapped outgrowth endothelial cells (OEC) and mese...
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#1Shahin Shams (UC Davis: University of California, Davis)H-Index: 1
#2Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 22
Abstract More than 2500 clinical trials involving gene therapy have been recorded worldwide and recently FDA approval was achieved for several gene therapy approaches. Now, one of the focuses could be on furthering the design of appropriate delivery vehicles where local, sustained, and controlled expression of therapeutic nucleic acids and/or proteins can be accomplished. This chapter looks at gene therapies and their delivery strategies in applications of tissue regeneration and disease treatme...
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Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) are orthobiologic therapies considered as an alternative to the current therapies for muscle, bone and cartilage. Different formulations of biomaterials have been used as carriers for PRP and BMAC in order to increase regenerative processes. The most common biomaterials utilized in conjunction with PRP and BMAC clinical trials are organic scaffolds and natural or synthetic polymers. This review will cover the combinatorial st...
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#1Dustin J. Hadley (UC Davis: University of California, Davis)H-Index: 1
#2Marina H. Gabriel (UC Davis: University of California, Davis)
Last. Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 22
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Open-source designs represent an attractive and new tool for research as it provides both affordable and accessible options to the lab environment. In particular, with the advent of new and cheap additive manufacturing technologies, the open-source design of lab hardware enables others to perform research that would be difficult otherwise. This manuscript describes an air-jet system designed to be open-source and simple to produce with 3D printing. The fully 3D printed air-jet was designed for t...
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#1Dustin J. Hadley (UC Davis: University of California, Davis)H-Index: 1
#2Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 22
Alginate hydrogels have been extensively used and successfully validated as delivery vehicles of bioactive factors in many tissue engineering applications. This work describes and characterizes a singular alternative method to create alginate hydrogels designated as thaw-induced gelation (TIG). The TIG method involves gelation through the time-dependent release of the polymer or crosslinker by melting into solution. Alginate TIG hydrogels were validated for spatial–temporal control delivery of d...
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#1Hugo RibeiroH-Index: 8
#2Alfredo MartinsH-Index: 11
Last. Catarina MagalhãesH-Index: 17
view all 14 authors...
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#1Justin L. Madrigal (UC Davis: University of California, Davis)H-Index: 4
#2Shahin Shams (UC Davis: University of California, Davis)H-Index: 1
Last. Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 22
view all 4 authors...
Gene therapy using viral vectors has been licensed for clinical use both in the European Union and the United States. Lentivectors (LV) and adeno-associated vectors (AAV) are two promising and FDA approved gene-therapy viral vectors. Many future applications of these vectors will benefit from targeting specific regions of interest within the body. Therefore, building on the early success of these vectors may depend on finding effective delivery systems to localize therapeutic administration. Deg...
1 CitationsSource
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