Lucie Carrier
University of Hamburg
140Publications
42H-index
5,968Citations
Publications 140
Newest
Published on Feb 1, 2019in Journal of Molecular and Cellular Cardiology 5.30
Karoline Morhenn (University of Hamburg), Thomas Quentin1
Estimated H-index: 1
(University of Hamburg)
+ 15 AuthorsFriedrich A. Schöndube20
Estimated H-index: 20
(University of Göttingen)
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca 2+ , chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca 2+ . In the present study, the regulation of CRTC1 in cardiomyocytes and its effect on...
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Published on Mar 1, 2019in Biochimica et Biophysica Acta 3.44
Antonia T.L. Zech1
Estimated H-index: 1
,
Sonia R. Singh3
Estimated H-index: 3
+ 1 AuthorsLucie Carrier42
Estimated H-index: 42
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Published on Jan 7, 2019in The Journal of General Physiology 3.68
Nicoletta Piroddi23
Estimated H-index: 23
(University of Florence),
E. Rosalie Witjas-Paalberends9
Estimated H-index: 9
(VU University Amsterdam)
+ 18 AuthorsCristobal G. dos Remedios45
Estimated H-index: 45
(University of Sydney)
Hypertrophic cardiomyopathy (HCM) is a genetic form of left ventricular hypertrophy, primarily caused by mutations in sarcomere proteins. The cardiac remodeling that occurs as the disease develops can mask the pathogenic impact of the mutation. Here, to discriminate between mutation-induced and disease-related changes in myofilament function, we investigate the pathogenic mechanisms underlying HCM in a patient carrying a homozygous mutation (K280N) in the cardiac troponin T gene ( TNNT2 ), which...
2 Citations Source Cite
Published on Feb 5, 2019in Circulation 18.88
Lucie Carrier42
Estimated H-index: 42
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Published on Oct 15, 2018in Pflügers Archiv: European Journal of Physiology 2.77
EschenhagenThomas65
Estimated H-index: 65
(University of Hamburg),
Lucie Carrier42
Estimated H-index: 42
(University of Hamburg)
Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at high efficiency and are increasingly used to study cardiac disease in a human context. This review evaluated 38 studies on hypertrophic (HCM) and dilated cardiomyopathy (DCM) of different genetic causes asking to which extent published data allow the definition of an in vitro HCM/DCM hiPSC-CM phenotype. The data are put in context with the prevailing hypotheses on HCM/DCM dysfunction and pathophysiology. Rela...
1 Citations Source Cite
Published on Nov 14, 2018in European Heart Journal 23.43
Diogo Mosqueira3
Estimated H-index: 3
(University of Nottingham),
Ingra Mannhardt10
Estimated H-index: 10
(University of Hamburg)
+ 14 AuthorsAndrew Tinker28
Estimated H-index: 28
(Queen Mary University of London)
Aims: Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a prevalent and complex condition leading to left ventricle thickening and heart dysfunction. We evaluated isogenic genome-edited human pluripotent stem cell-cardiomyocytes (hPSC-CM) for their validity to model, and add clarity to, HCM. Methods and results: CRISPR/Cas9 editing produced 11 variants of the HCM-causing mutation c.C9123T-MYH7 (p.R453C-βMHC) in 3 independent hPSC lines. Isogenic sets were different...
12 Citations Source Cite
Published on Sep 19, 2018in Frontiers in Physiology 3.39
Simon Braumann (University of Hamburg), Tilo Thottakara1
Estimated H-index: 1
(University of Hamburg)
+ 7 AuthorsFelix W. Friedrich12
Estimated H-index: 12
(University of Hamburg)
Background: S100A4 has recently emerged as an important player in cardiac disease, affecting phenotype development in animal models of myocardial infarction and pathological cardiac hypertrophy, albeit it is unclear whether S100A4 exerts a detrimental or beneficial function. The goal of the current study was to analyze S100A4 expression in models of cardiac pathology, investigate its degradation by the ubiquitin-proteasome system and furthermore examine the functional effects of S100A4 levels in...
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Published on Oct 8, 2018in European Heart Journal 23.43
Christoph Maack28
Estimated H-index: 28
,
EschenhagenThomas65
Estimated H-index: 65
(University of Hamburg)
+ 36 AuthorsM. Birhan Yilmaz9
Estimated H-index: 9
(Cumhuriyet University)
Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. Newer drugs, such as levosimendan or omecamtiv mecarbil, target sarcomeres to improve systolic function putatively without elevating intracellular Ca2+. Although meta-analyses of smaller trials suggested that levosimendan is...
1 Citations Source Cite
Published on Jul 3, 2018in Pflügers Archiv: European Journal of Physiology 2.77
Maksymilian Prondzynski6
Estimated H-index: 6
(University of Hamburg),
Giulia Mearini15
Estimated H-index: 15
(University of Hamburg),
Lucie Carrier42
Estimated H-index: 42
(University of Hamburg)
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
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Published on Jul 1, 2017in Toxicological Sciences 4.18
Ingra Mannhardt10
Estimated H-index: 10
(University of Hamburg),
EderAlexandra15
Estimated H-index: 15
(University of Hamburg)
+ 11 AuthorsMarc D. Lemoine3
Estimated H-index: 3
(University of Hamburg)
2 Citations Source Cite
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