Match!
Lucie Carrier
University of Hamburg
141Publications
43H-index
6,071Citations
Publications 141
Newest
Published in Journal of Anatomy2.64
Patricia Garcia-Canadilla5
Estimated H-index: 5
(UCL: University College London),
Andrew C. Cook14
Estimated H-index: 14
(UCL: University College London)
+ -3 AuthorsGabriella Captur14
Estimated H-index: 14
(UCL: University College London)
Published on Jul 13, 2019
Kathrin Cordts5
Estimated H-index: 5
,
Doreen Seelig + 6 AuthorsMonica Patten4
Estimated H-index: 4
Despite genetic heterogeneity, early manifestation of diastolic dysfunction (DD) is common in hypertrophic cardiomyopathy (HCM). Nitric oxide (NO) may contribute to myocardial relaxation. NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS. This study aimed to analyze the association of Arg and its derivates, i.e., l-homoarginine (hArg), ADMA and symmetric dimethylarginine (SDMA), with DD in HCM patients. In 215 HC...
Published on May 1, 2019in Pflügers Archiv: European Journal of Physiology3.38
EschenhagenThomas66
Estimated H-index: 66
(UHH: University of Hamburg),
Lucie Carrier43
Estimated H-index: 43
(UHH: University of Hamburg)
Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at high efficiency and are increasingly used to study cardiac disease in a human context. This review evaluated 38 studies on hypertrophic (HCM) and dilated cardiomyopathy (DCM) of different genetic causes asking to which extent published data allow the definition of an in vitro HCM/DCM hiPSC-CM phenotype. The data are put in context with the prevailing hypotheses on HCM/DCM dysfunction and pathophysiology. Rela...
Published on May 1, 2019in Pflügers Archiv: European Journal of Physiology3.38
Maksymilian Prondzynski6
Estimated H-index: 6
(UHH: University of Hamburg),
Giulia Mearini16
Estimated H-index: 16
(UHH: University of Hamburg),
Lucie Carrier43
Estimated H-index: 43
(UHH: University of Hamburg)
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
Published on Apr 24, 2019in Human Mutation4.45
Konstantinos Kolokotronis , Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)+ 8 AuthorsSabine Klaassen (Humboldt University of Berlin)
Published on Mar 28, 2019in Frontiers in Physiology3.20
Nico Kresin1
Estimated H-index: 1
,
Sabrina Stücker1
Estimated H-index: 1
+ 7 AuthorsLucie Carrier43
Estimated H-index: 43
Background. Many forms of hypertrophic cardiomyopathy (HCM) show an increased myofilament Ca2+ sensitivity. This observation has been mainly made in HCM mouse models, myofilament systems, and cardiomyocytes. Studies of multicellular tissues from patients with different HCM-associated gene mutations are scarce. We investigated Ca2+ sensitivity in multicellular cardiac muscle strips of HCM patients. We furthermore evaluated the use of epigallocatechin-3-gallate (EGCg), a Ca2+ desensitizer. Methods...
Published on Mar 1, 2019in Biochimica et Biophysica Acta3.79
Antonia T.L. Zech1
Estimated H-index: 1
,
Sonia R. Singh2
Estimated H-index: 2
(Cincinnati Children's Hospital Medical Center)
+ 1 AuthorsLucie Carrier43
Estimated H-index: 43
Abstract Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function...
Published on Feb 5, 2019in Circulation23.05
Lucie Carrier43
Estimated H-index: 43
Published on Feb 1, 2019in Journal of Molecular and Cellular Cardiology5.05
Karoline Morhenn (UHH: University of Hamburg), Thomas Quentin1
Estimated H-index: 1
(UHH: University of Hamburg)
+ 15 AuthorsFriedrich A. Schöndube26
Estimated H-index: 26
(GAU: University of Göttingen)
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca 2+ , chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca 2+ . In the present study, the regulation of CRTC1 in cardiomyocytes and its effect on...
Published on Jan 7, 2019in The Journal of General Physiology4.26
Nicoletta Piroddi23
Estimated H-index: 23
(UniFI: University of Florence),
E. Rosalie Witjas-Paalberends9
Estimated H-index: 9
(VU: VU University Amsterdam)
+ 18 AuthorsCristobal G. dos Remedios46
Estimated H-index: 46
(USYD: University of Sydney)
Hypertrophic cardiomyopathy (HCM) is a genetic form of left ventricular hypertrophy, primarily caused by mutations in sarcomere proteins. The cardiac remodeling that occurs as the disease develops can mask the pathogenic impact of the mutation. Here, to discriminate between mutation-induced and disease-related changes in myofilament function, we investigate the pathogenic mechanisms underlying HCM in a patient carrying a homozygous mutation (K280N) in the cardiac troponin T gene ( TNNT2 ), which...
12345678910