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Lucie Carrier
University of Hamburg
141Publications
43H-index
6,071Citations
Publications 141
Newest
Published on May 1, 2019in Pflügers Archiv: European Journal of Physiology 2.77
EschenhagenThomas66
Estimated H-index: 66
(University of Hamburg),
Lucie Carrier43
Estimated H-index: 43
(University of Hamburg)
Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at high efficiency and are increasingly used to study cardiac disease in a human context. This review evaluated 38 studies on hypertrophic (HCM) and dilated cardiomyopathy (DCM) of different genetic causes asking to which extent published data allow the definition of an in vitro HCM/DCM hiPSC-CM phenotype. The data are put in context with the prevailing hypotheses on HCM/DCM dysfunction and pathophysiology. Rela...
3 Citations Source Cite
Published on May 1, 2019in Pflügers Archiv: European Journal of Physiology 2.77
Maksymilian Prondzynski6
Estimated H-index: 6
(University of Hamburg),
Giulia Mearini16
Estimated H-index: 16
(University of Hamburg),
Lucie Carrier43
Estimated H-index: 43
(University of Hamburg)
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
1 Citations Source Cite
Published on Apr 24, 2019in Human Mutation 5.36
Konstantinos Kolokotronis , Jirko Kühnisch (Max Delbrück Center for Molecular Medicine)+ 8 AuthorsSabine Klaassen (Humboldt University of Berlin)
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Published on Mar 28, 2019in Frontiers in Physiology 3.39
Nico Kresin1
Estimated H-index: 1
,
Sabrina Stücker1
Estimated H-index: 1
+ 7 AuthorsFelix W. Friedrich13
Estimated H-index: 13
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Published on Mar 1, 2019in Biochimica et Biophysica Acta 3.44
Antonia T.L. Zech1
Estimated H-index: 1
,
Sonia R. Singh2
Estimated H-index: 2
(Cincinnati Children's Hospital Medical Center)
+ 1 AuthorsLucie Carrier43
Estimated H-index: 43
Abstract Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function...
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Published on Feb 5, 2019in Circulation 18.88
Lucie Carrier43
Estimated H-index: 43
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Published on Feb 1, 2019in Journal of Molecular and Cellular Cardiology 5.30
Karoline Morhenn (University of Hamburg), Thomas Quentin1
Estimated H-index: 1
(University of Hamburg)
+ 15 AuthorsFriedrich A. Schöndube26
Estimated H-index: 26
(University of Göttingen)
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca 2+ , chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca 2+ . In the present study, the regulation of CRTC1 in cardiomyocytes and its effect on...
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Published on Jan 7, 2019in The Journal of General Physiology 3.68
Nicoletta Piroddi23
Estimated H-index: 23
(University of Florence),
E. Rosalie Witjas-Paalberends9
Estimated H-index: 9
(VU University Amsterdam)
+ 18 AuthorsCristobal G. dos Remedios46
Estimated H-index: 46
(University of Sydney)
Hypertrophic cardiomyopathy (HCM) is a genetic form of left ventricular hypertrophy, primarily caused by mutations in sarcomere proteins. The cardiac remodeling that occurs as the disease develops can mask the pathogenic impact of the mutation. Here, to discriminate between mutation-induced and disease-related changes in myofilament function, we investigate the pathogenic mechanisms underlying HCM in a patient carrying a homozygous mutation (K280N) in the cardiac troponin T gene ( TNNT2 ), which...
3 Citations Source Cite
Published on Nov 14, 2018in European Heart Journal 23.43
Diogo Mosqueira3
Estimated H-index: 3
(University of Nottingham),
Ingra Mannhardt10
Estimated H-index: 10
(University of Hamburg)
+ 14 AuthorsAndrew Tinker28
Estimated H-index: 28
(Queen Mary University of London)
Aims: Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a prevalent and complex condition leading to left ventricle thickening and heart dysfunction. We evaluated isogenic genome-edited human pluripotent stem cell-cardiomyocytes (hPSC-CM) for their validity to model, and add clarity to, HCM. Methods and results: CRISPR/Cas9 editing produced 11 variants of the HCM-causing mutation c.C9123T-MYH7 (p.R453C-βMHC) in 3 independent hPSC lines. Isogenic sets were different...
15 Citations Source Cite
Published on Oct 8, 2018in European Heart Journal 23.43
Christoph Maack29
Estimated H-index: 29
,
EschenhagenThomas66
Estimated H-index: 66
(University of Hamburg)
+ 36 AuthorsM. Birhan Yilmaz9
Estimated H-index: 9
(Cumhuriyet University)
Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. Newer drugs, such as levosimendan or omecamtiv mecarbil, target sarcomeres to improve systolic function putatively without elevating intracellular Ca2+. Although meta-analyses of smaller trials suggested that levosimendan is...
1 Citations Source Cite
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