Lucie Carrier
University of Hamburg
Publications 141
#1Patricia Garcia-Canadilla (UCL: University College London)H-Index: 5
#2Andrew C. Cook (UCL: University College London)H-Index: 14
Last.Gabriella Captur (UCL: University College London)H-Index: 14
view all 0 authors...
#1Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 14
#2C. Herbst (MDC: Max Delbrück Center for Molecular Medicine)
Last.Brenda GerullH-Index: 20
view all 0 authors...
#1Kathrin CordtsH-Index: 5
Last.Monica PattenH-Index: 4
view all 9 authors...
Despite genetic heterogeneity, early manifestation of diastolic dysfunction (DD) is common in hypertrophic cardiomyopathy (HCM). Nitric oxide (NO) may contribute to myocardial relaxation. NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS. This study aimed to analyze the association of Arg and its derivates, i.e., l-homoarginine (hArg), ADMA and symmetric dimethylarginine (SDMA), with DD in HCM patients. In 215 HC...
#1EschenhagenThomas (UHH: University of Hamburg)H-Index: 66
#2Lucie Carrier (UHH: University of Hamburg)H-Index: 43
Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at high efficiency and are increasingly used to study cardiac disease in a human context. This review evaluated 38 studies on hypertrophic (HCM) and dilated cardiomyopathy (DCM) of different genetic causes asking to which extent published data allow the definition of an in vitro HCM/DCM hiPSC-CM phenotype. The data are put in context with the prevailing hypotheses on HCM/DCM dysfunction and pathophysiology. Rela...
#1Maksymilian Prondzynski (UHH: University of Hamburg)H-Index: 6
#2Giulia Mearini (UHH: University of Hamburg)H-Index: 16
Last.Lucie Carrier (UHH: University of Hamburg)H-Index: 43
view all 3 authors...
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
#1Antonia T.L. ZechH-Index: 1
#2Sonia R. Singh (Cincinnati Children's Hospital Medical Center)H-Index: 2
Last.Lucie CarrierH-Index: 43
view all 4 authors...
Abstract Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function...
#1Karoline Morhenn (UHH: University of Hamburg)
#2Thomas Quentin (UHH: University of Hamburg)H-Index: 1
Last.Friedrich A. Schöndube (GAU: University of Göttingen)H-Index: 26
view all 18 authors...
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca 2+ , chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca 2+ . In the present study, the regulation of CRTC1 in cardiomyocytes and its effect on...
#1Nicoletta Piroddi (UniFI: University of Florence)H-Index: 23
#2E. Rosalie Witjas-Paalberends (VU: VU University Amsterdam)H-Index: 9
Last.Cristobal G. dos Remedios (USYD: University of Sydney)H-Index: 46
view all 21 authors...
Hypertrophic cardiomyopathy (HCM) is a genetic form of left ventricular hypertrophy, primarily caused by mutations in sarcomere proteins. The cardiac remodeling that occurs as the disease develops can mask the pathogenic impact of the mutation. Here, to discriminate between mutation-induced and disease-related changes in myofilament function, we investigate the pathogenic mechanisms underlying HCM in a patient carrying a homozygous mutation (K280N) in the cardiac troponin T gene ( TNNT2 ), which...