Lucie Carrier
University of Hamburg
Publications 146
#1Alexander Dutsch (TUM: Technische Universität München)H-Index: 2
#2Paul J. M. Wijnker (UHH: University of Hamburg)
Last.Giulia Mearini (UHH: University of Hamburg)H-Index: 16
view all 13 authors...
Phosphorylation of cardiac myosin-binding protein C (cMyBP-C), encoded by MYBPC3, increases the availability of myosin heads for interaction with actin thus enhancing contraction. cMyBP-C phosphorylation level is lower in septal myectomies of patients with hypertrophic cardiomyopathy (HCM) than in non-failing hearts. Here we compared the effect of phosphomimetic (D282) and wild-type (S282) cMyBP-C gene transfer on the HCM phenotype of engineered heart tissues (EHTs) generated from a mouse model ...
#1Maksymilian Prondzynski (UHH: University of Hamburg)H-Index: 8
#2Marc D. Lemoine (UHH: University of Hamburg)H-Index: 6
Last.Lucie Carrier (UHH: University of Hamburg)H-Index: 44
view all 25 authors...
3 CitationsSource
#1Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 14
#2Christopher Herbst (MDC: Max Delbrück Center for Molecular Medicine)
Last.Sabine Klaassen (Humboldt University of Berlin)H-Index: 15
view all 17 authors...
#1Patricia Garcia-Canadilla (UCL: University College London)H-Index: 6
#2Andrew C. Cook (UCL: University College London)H-Index: 14
Last.Gabriella Captur (UCL: University College London)H-Index: 17
view all 9 authors...
Myoarchitectural disarray – the multiscalar disorganisation of myocytes, is a recognised histopathological hallmark of adult human hypertrophic cardiomyopathy (HCM). It occurs before the establishment of left ventricular hypertrophy (LVH) but its early origins and evolution around the time of birth are unknown. Our aim is to investigate whether myoarchitectural abnormalities in HCM are present in the fetal heart. We used wild‐type, heterozygous and homozygous hearts (n = 56) from a Mybpc3‐target...
1 CitationsSource
#1Kathrin CordtsH-Index: 5
Last.Monica PattenH-Index: 5
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Despite genetic heterogeneity, early manifestation of diastolic dysfunction (DD) is common in hypertrophic cardiomyopathy (HCM). Nitric oxide (NO) may contribute to myocardial relaxation. NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS. This study aimed to analyze the association of Arg and its derivates, i.e., l-homoarginine (hArg), ADMA and symmetric dimethylarginine (SDMA), with DD in HCM patients. In 215 HC...
#1EschenhagenThomas (UHH: University of Hamburg)H-Index: 68
#2Lucie Carrier (UHH: University of Hamburg)H-Index: 44
Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at high efficiency and are increasingly used to study cardiac disease in a human context. This review evaluated 38 studies on hypertrophic (HCM) and dilated cardiomyopathy (DCM) of different genetic causes asking to which extent published data allow the definition of an in vitro HCM/DCM hiPSC-CM phenotype. The data are put in context with the prevailing hypotheses on HCM/DCM dysfunction and pathophysiology. Rela...
6 CitationsSource
#1Maksymilian Prondzynski (UHH: University of Hamburg)H-Index: 8
#2Giulia Mearini (UHH: University of Hamburg)H-Index: 16
Last.Lucie Carrier (UHH: University of Hamburg)H-Index: 44
view all 3 authors...
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
3 CitationsSource
#2Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 14
Last.Brenda GerullH-Index: 21
view all 11 authors...
2 CitationsSource
#1Antonia T.L. ZechH-Index: 1
#2Sonia R. Singh (Cincinnati Children's Hospital Medical Center)H-Index: 2
Last.Lucie CarrierH-Index: 44
view all 4 authors...
Abstract Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function...
1 CitationsSource