M. Craig Miller
Brown University
CancerProstateProstate cancerCirculating tumor cellMedicine
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Publications 75
#1Neil M. Carleton (JHUSOM: Johns Hopkins University School of Medicine)
#2Guangjing Zhu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
Last. Robert W. Veltri (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
view all 6 authors...
#1Afroditi Nanou (UT: University of Twente)H-Index: 3
#2M. Craig MillerH-Index: 35
Last. Leon W. M. M. Terstappen (UT: University of Twente)H-Index: 50
view all 9 authors...
Circulating tumour cells (CTCs) in blood associate with overall survival (OS) of cancer patients, but they are detected in extremely low numbers. Large tumour-derived extracellular vesicles (tdEVs) in castration-resistant prostate cancer (CRPC) patients are present at around 20 times higher frequencies than CTCs and have equivalent prognostic power. In this study, we explored the presence of tdEVs in other cancers and their association with OS. The open-source ACCEPT software was used to automat...
#1M. Craig MillerH-Index: 35
#2Peggy S. RobinsonH-Index: 1
Last. Daniel J. O'ShannessyH-Index: 1
view all 4 authors...
10 CitationsSource
#1Neil M. CarletonH-Index: 2
#2Guangjing Zhu (Johns Hopkins University)H-Index: 5
Last. Robert W. Veltri (Johns Hopkins University)H-Index: 40
view all 7 authors...
4 CitationsSource
#1Neil M. CarletonH-Index: 2
#3Guangjing ZhuH-Index: 5
view all 6 authors...
#1Guangjing Zhu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
#2Zhi Liu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
Last. Robert W. Veltri (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
view all 12 authors...
Background: Early prediction of disease progression in men with very low-risk (VLR) prostate cancer who selected active surveillance (AS) rather than immediate treatment could reduce morbidity associated with overtreatment. Methods: We evaluated the association of six biomarkers [Periostin, (−5, −7) proPSA, CACNA1D, HER2/neu, EZH2, and Ki-67] with different Gleason scores and biochemical recurrence (BCR) on prostate cancer TMAs of 80 radical prostatectomy (RP) cases. Multiplex tissue immunoblott...
5 CitationsSource
#1Elizabeth Lokich (Brown University)H-Index: 3
#2M. Palisoul (Brown University)H-Index: 1
Last. Richard G. Moore (Brown University)H-Index: 28
view all 11 authors...
Objective To evaluate the use of as an aid in the identification of women who can safely undergo conservative, non-surgical management.
6 CitationsSource
#1Costanza Paoletti (UM: University of Michigan)H-Index: 12
#2Maria C. Muñiz (UM: University of Michigan)H-Index: 7
Last. Daniel F. Hayes (UM: University of Michigan)H-Index: 106
view all 16 authors...
Background: Endocrine therapy (ET) fails to induce a response in one half of patients with hormone receptor (HR)–positive metastatic breast cancer (MBC), and almost all will eventually become refractory to ET. Circulating tumor cells (CTC) are associated with worse prognosis in patients with MBC, but enumeration alone is insufficient to predict the absolute odds of benefit from any therapy, including ET. We developed a multiparameter CTC-Endocrine Therapy Index (CTC-ETI), which we hypothesize ma...
65 CitationsSource
#1Richard G. MooreH-Index: 28
#2Emily K. HillH-Index: 8
Last. Rakesh K. SinghH-Index: 51
view all 12 authors...
Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian cancer tumorigenesis but little is known about the role the HE4 gene or the gene product plays. Here we show that elevated HE4 serum levels correlate with chemoresistance and decreased survival rates in EOC patients. HE4 overexpression promoted xenograft tumor growth and chemoresistance against cisplatin in an animal model resulting in reduced survival rates. HE4 displayed responses to tumor micro...
29 CitationsSource
#1Richard G. Moore (Brown University)H-Index: 28
#2Douglas M. Hawkins (UMN: University of Minnesota)H-Index: 54
Last. Steven J. Skates (Harvard University)H-Index: 59
view all 8 authors...
Abstract Objectives ACOG guidelines for the evaluation of women with a pelvic mass employ a combination of physical exam, imaging, and CA125 to guide physicians in the triage of women to gynecologic oncologists. We studied the use of ROMA with clinical assessment for cancer risk assessment in women with a pelvic mass. Methods This was a prospective, multicenter trial evaluating women with a pelvic mass who had an initial clinical risk assessment (ICRA) performed by a generalist. ROMA scores were...
5 CitationsSource