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Lyoung Hyo Kim
Sogang University
Single-nucleotide polymorphismHaplotypePopulationGeneticsBiology
77Publications
26H-index
2,102Citations
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Publications 74
Newest
#1Lyoung Hyo KimH-Index: 26
#2Jeong Hyun Kim (UOU: University of Ulsan)H-Index: 1
Last. Hyoung Doo Shin (Sogang University)H-Index: 47
view all 10 authors...
Purpose Previous studies have revealed that PHLDB1 single-nucleotide polymorphisms (SNPs) are associated with glioma risk. Nonetheless, the association between PHLDB1 SNPs and the risk of pituitary adenoma has not been studied. The present study evaluated the association of PHLDB1 SNPs with the risk of pituitary adenomas.
Source
#1Joong Gon Shin (Sogang University)H-Index: 4
#2Hyun Sub Cheong (Sogang University)H-Index: 26
Last. Hyoung Doo Shin (Sogang University)H-Index: 47
view all 13 authors...
Chronic hepatitis B (CHB) is a precursor to liver cirrhosis and hepatocellular carcinoma, caused by a Hepatitis B viral infection. Genome-wide association studies (GWASs) have been conducted to find genes associated with CHB risk. In previous GWAS, EHMT2 was identified as one of the susceptibility genes for CHB. To further characterize this association and discover possible causal variants, we conducted an additional association study. A total of 11 EHMT2 single-nucleotide polymorphisms (SNP) we...
2 CitationsSource
#1Suhg Namgoong (Sogang University)H-Index: 6
#2Hyun Sub CheongH-Index: 26
Last. Hyoung Doo Shin (Sogang University)H-Index: 47
view all 10 authors...
Previous studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma pa...
Source
#1Suhg Namgoong (Sogang University)H-Index: 6
#2Joong Gon Shin (Sogang University)H-Index: 4
Last. Yoon Jun Kim (SNU: Seoul National University)H-Index: 39
view all 8 authors...
BACKGROUND & AIMS: Numerous single nucleotide polymorphisms associated with an increased risk of liver diseases, chronic hepatitis B and chronic hepatitis B-related hepatocellular carcinoma have been identified. In this study, we scrutinized the genetic effects of C2 variants, which were conflicting in previous results, on the risk of chronic hepatitis B in a Korean population. METHODS: We genotyped 22 common C2 genetic variants of 977 chronic hepatitis B cases including 302 chronic hepatitis B-...
1 CitationsSource
#1Joong Gon Shin (Sogang University)H-Index: 4
#2Hyun Sub Cheong (Sogang University)H-Index: 26
Last. Hyoung Doo Shin (Sogang University)H-Index: 47
view all 14 authors...
Background & Aims Hepatitis B viral infection is serious risk factor for chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma. Recently, several genome-wide association studies (GWASs) have been conducted to identify important genetic associated with the risk of CHB. In our previous GWAS, TCF19 was identified as one of the susceptibility genes for CHB risk (P = 4.2×10-9 at rs1419881). In order to discover possible additional causal variants around TCF19, we performed an assoc...
3 CitationsSource
#1Lyoung Hyo KimH-Index: 26
#2Hun-Soo ChangH-Index: 3
Last. Hyoung Doo ShinH-Index: 47
view all 14 authors...
Abstract Aspirin-exacerbated respiratory disease (AERD) is characterized by a severe and sudden asthma attack after aspirin ingestion in patients with asthma. We studied associations with six common single nucleotide polymorphisms (SNP) of the gasdermin B gene (GSDMB). DNA obtained from 572 patients with asthma (with AERD, n = 165; and with aspirin-tolerant asthma, n = 407) and 391 normal controls was subjected to genotyping of six SNPs of GSDMB. An association analysis between GSDMB variants an...
1 CitationsSource
#1Lyoung Hyo Kim (Sogang University)H-Index: 26
#2Byung Lae ParkH-Index: 33
Last. Sung Il Woo (Soonchunhyang University Hospital)H-Index: 4
view all 14 authors...
Schizophrenia is regarded as a multifactorial and polygenic brain disorder that is attributed to different combinations of genetic and environmental risk factors. Recently, several genome-wide association studies (GWASs) of schizophrenia have identified numerous risk factors, but the replication results remain controversial and ambiguous. To identify schizophrenia susceptibility loci in the Korean population, we performed a GWAS using the Illumina HumanOmni1-Quad V1.0 Microarray. We genotyped 1,...
1 CitationsSource
#1Lyoung Hyo Kim (Sogang University)H-Index: 26
#2Hyun Sub Cheong (Seoul National University Hospital)H-Index: 26
Last. Sung-Soo Yoon (SNU: Seoul National University)H-Index: 35
view all 8 authors...
The cytidine deaminase (CDA) catalyzes the irreversible hydrolytic deamination of the cytarabine (AraC) into a 1-β-D-arabinofuranosyluracil (AraU), an inactive metabolite that plays a crucial role in lowering the amount of AraC, a key chemotherapeutic drug, in the treatment of patients with acute myeloid leukemia (AML). In this study, we hypothesized that CDA polymorphisms were associated with the AraC metabolism for AML treatment and/or related clinical phenotypes. We analyzed 16 polymorphisms ...
9 CitationsSource
#1Suhg Namgoong (Sogang University)H-Index: 6
#2Hyun Sub Cheong (Sogang University)H-Index: 26
Last. Hyoung Doo Shin (Sogang University)H-Index: 47
view all 8 authors...
Organic anion-transporting polypeptide (OATP; gene symbol, SLCO) transporters are generally involved in the uptake of multiple drugs and their metabolites at most epithelial barriers. The pattern of single-nucleotide polymorphisms (SNPs) in these transporters may be determinants of interindividual variability in drug disposition and response. The objective of this study was to define the distribution of SNPs of three SLCO genes, SLCO1B1, SLCO1B3, and SLCO2B1, in a Korean population and other eth...
4 CitationsSource
#1Hyun Sub Cheong (Sogang University)H-Index: 26
#2Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 24
Last. Yoon Jun Kim (SNU: Seoul National University)H-Index: 4
view all 13 authors...
Background & Aims Hepatitis B virus (HBV) infection is the most serious risk factor for chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma. Recently, several genome-wide association studies (GWASs) identified important variants associated with the risk of CHB in Asian populations. Specifically, our previous GWAS identified the VARS2-SFTA2 gene region as one of the genetic risk loci for CHB. Methods To further characterize this association and to isolate possible causal variants w...
8 CitationsSource
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