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Paul Battlay
University of Melbourne
10Publications
5H-index
149Citations
Publications 10
Newest
#1Llewellyn Green (University of Melbourne)H-Index: 3
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 5 authors...
Insecticide resistance is a paradigm of microevolution, and insecticides are responsible for the strongest cases of recent selection in the genome of Drosophila melanogaster . Here we use a naive population and a novel insecticide class to examine the ab initio genetic architecture of a potential selective response. Genome-wide association studies (GWAS) of chlorantraniliprole susceptibility reveal variation in a gene of major effect, Stretchin Myosin light chain kinase ( Strn-Mlck ), which we v...
#1Alexandre Fournier-Level (University of Melbourne)H-Index: 15
#2Robert T. Good (University of Melbourne)H-Index: 21
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 11 authors...
Imidacloprid, the world’s most used insecticide, has caused considerable controversy due to harmful effects on non-pest species and increasing evidence showing that insecticides have become the primary selective force in many insect species. The genetic response to insecticides is heterogeneous across populations and environments, leading to more complex patterns of genetic variation than previously thought. This motivated the investigation of imidacloprid resistance at different temperatures in...
#1Charles Robin (University of Melbourne)H-Index: 20
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Alexandre Fournier-Level (University of Melbourne)H-Index: 15
view all 3 authors...
If we are to fully comprehend the evolution of insect diversity at a genomic level we need to understand how natural selection can alter genetically encoded characters within populations. Genetic association panels have the potential to be standard bearers in this endeavour. They enable the mapping of phenotypes to genotypes at unprecedented resolution while simultaneously providing population genomic samples that can be interrogated for the tell-tale signs of selection. Analyses of these panels...
#1Paul Battlay (University of Melbourne)H-Index: 5
#2Pontus B. Leblanc (University of Melbourne)H-Index: 2
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 7 authors...
Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. However, there is a need to explicitly link selective sweeps to the particular insecticide phenotypes that could plausibly account for the drastic selective responses that are observed in these non-target insects. Here, we screen the Drosophila Genetic Reference Panel with two common insecticides; mala...
#1Shane Denecke (University of Melbourne)H-Index: 4
#2Roberto Fusetto (University of Melbourne)H-Index: 3
Last.Philip Batterham (University of Melbourne)H-Index: 33
view all 8 authors...
Insecticide resistance is an economically important example of evolution in response to intense selection pressure. Here, the genetics of resistance to the neonicotinoid insecticide imidacloprid is explored using the Drosophila Genetic Reference Panel, a collection of inbred Drosophila melanogaster genotypes derived from a single population in North Carolina. Imidacloprid resistance varied substantially among genotypes, and more resistant genotypes tended to show increased capacity to metabolize...
#1Joshua M. Schmidt (MPG: Max Planck Society)H-Index: 7
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 7 authors...
Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In contrast, multiple variants have been implicated in DDT resistance in Drosophila melanogaster ; however...
#1Shane Denecke (University of Melbourne)H-Index: 4
#2Roberto Fusetto (University of Melbourne)H-Index: 3
Last.Philip Batterham (University of Melbourne)H-Index: 33
view all 8 authors...
Insecticide resistance is an economically important example of evolution in response to intense selection pressure. Here, the genetics of resistance to the neonicotinoid insecticide imidacloprid is explored using the Drosophila Genetic Reference Panel, a collection of inbred Drosophila melanogaster genotypes derived from a single population in North Carolina. Imidacloprid resistance varied substantially among genotypes, and more resistant genotypes tended to show increased capacity to metabolize...
#1Paul Battlay (University of Melbourne)H-Index: 5
#2Joshua M. Schmidt (University of Melbourne)H-Index: 7
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 4 authors...
Scans of the Drosophila melanogaster genome have identified organophosphate resistance loci among those with the most pronounced signature of positive selection. In this study, the molecular basis of resistance to the organophosphate insecticide azinphos-methyl was investigated using the Drosophila Genetic Reference Panel, and genome-wide association. Recently released full transcriptome data were used to extend the utility of the Drosophila Genetic Reference Panel resource beyond traditional ge...
#1Robert T. Good (University of Melbourne)H-Index: 21
#2Lydia Gramzow (FSU: University of Jena)H-Index: 12
Last.Charles Robin (University of Melbourne)H-Index: 20
view all 6 authors...
We map 114 gene gains and 74 gene losses in the P450 gene family across the phylogeny of 12 Drosophila species by examining the congruence of gene trees and species trees. Although the number of P450 genes varies from 74 to 94 in the species examined, we infer that there were at least 77 P450 genes in the ancestral Drosophila genome. One of the most striking observations in the data set is the elevated loss of P450 genes in the Drosophila sechellia lineage. The gain and loss events are not evenl...
#1Kin Kuan Hoi (University of Melbourne)H-Index: 5
#2Phillip J. Daborn (University of Melbourne)H-Index: 29
Last.William A. Donald (UNSW: University of New South Wales)H-Index: 20
view all 7 authors...
Insecticide resistance is one of the most prevalent examples of anthropogenic genetic change, yet our understanding of metabolic-based resistance remains limited by the analytical challenges associated with rapidly tracking the in vivo metabolites of insecticides at nonlethal doses. Here, using twin ion mass spectrometry analysis of the extracts of whole Drosophila larvae and excreta, we show that (i) eight metabolites of the neonicotinoid insecticide, imidacloprid, can be detected when formed b...
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