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Mahvash Shere
University of Toronto
6Publications
3H-index
61Citations
Publications 6
Newest
OBJECTIVES: To assess the percentage of women of childbearing age with suboptimal levels of folate for protecting against neural tube defects (<906 nM), and assess folate status among the elderly. METHODS: A total of 1,035 anonymous blood samples from a centralized clinical laboratory, with a catchment area across the Greater Toronto Area, were assessed for red blood cell (RBC) folate concentrations using a chemiluminescent immunoassay. Folate analysis was requested by physicians as part of clin...
2 CitationsSource
#1Mahvash Shere (U of T: University of Toronto)H-Index: 3
#2Priya Bapat (U of T: University of Toronto)H-Index: 7
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
view all 5 authors...
Abstract Objective To conduct a systematic review evaluating the effectiveness of a folate-fortified oral contraceptive preparation in increasing blood folate concentrations to levels providing optimal protection against neural tube defects (> 906 nmol/L). Methods We searched Medline, EMBASE, Web of Science, and the Cochrane Library for human studies published from inception to June 2013 that evaluated oral contraceptive use and folate status. Case–control studies, cohort studies, and clinical t...
7 CitationsSource
#1Mahvash Shere (U of T: University of Toronto)H-Index: 3
#2Priya Bapat (U of T: University of Toronto)H-Index: 7
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
view all 5 authors...
Abstract Objective To conduct a systematic review and meta-analysis of the effect of oral contraceptive use on plasma and red blood cell (RBC) folate concentrations. Methods We searched Medline, EMBASE, Web of Science, and the Cochrane library for human studies published from inception to June 2013 evaluating oral contraceptive use and folate status. Case-control studies, cohort studies, and clinical trials were included. A random-effects model of outcomes was used for the meta-analysis. Results...
14 CitationsSource
The objective of this randomized clinical trial was to compare steady-state gestational RBC and plasma folate concentrations in pregnant women supplementing daily with 1.1 mg (regular dose) vs. 5 mg (high dose) folic acid. Thirty-seven pregnant women, who were not previously taking folic acid, were enrolled in this open-label, 2-arm, randomized clinical trial after informed consent. Participants were randomly assigned either 1.1 or 5 mg of folic acid-containing prenatals until gestational age (g...
3 CitationsSource
#1Mahvash ShereH-Index: 3
#2Patricia NguyenH-Index: 7
Last.Gideon KorenH-Index: 79
view all 7 authors...
Background: Folic acid supplementation before and during pregnancy reduces the risk of neural tube defects. Although previous studies have investigated folate status in non-pregnant women of childbearing age, steady-state folate pharmacokinetics have never been evaluated in pregnant women to inform healthcare recommendations regarding the timing of prenatal multivitamin supplementation. Objective: To compare the steady-state periconceptional and gestational RBC and plasma folate levels in pregna...
2 Citations
#1Mahvash Shere (U of T: University of Toronto)H-Index: 3
#2Xiu Yan ZhaoH-Index: 1
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
view all 3 authors...
Background Recruitment of women in the periconceptional period to clinical studies using traditional advertising through medical establishments is difficult and slow. Given the widespread use of the internet as a source for medical information and research, we analyze the impact of social media in the second phase of an ongoing randomized, open-label clinical trial among pregnant women. This study aims to assess the effectiveness of social media as a recruitment tool through the comparison of di...
33 CitationsSource
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