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Kaitlyn Shaw
University of British Columbia
11Publications
5H-index
124Citations
Publications 11
Newest
#1Laura Smy (U of T: University of Toronto)H-Index: 2
#2Kaitlyn Shaw (UBC: University of British Columbia)H-Index: 5
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
view all 8 authors...
Abstract Background Inhaled corticosteroids (ICS) are the recommended long-term control therapy for asthma in children. However, concern exists regarding potential adrenal suppression with chronic ICS use. Our pilot study reported that hair cortisol in children was 50% lower during ICS therapy than prior to therapy, suggestive of adrenal suppression. Objective To evaluate hair cortisol concentration (HCC) as a potential biomarker for possible adrenal suppression from ICS use in children with ast...
2 CitationsSource
#1Neale Smith (UBC: University of British Columbia)H-Index: 14
#2Alice Wang (UBC: University of British Columbia)H-Index: 1
Last.Bruce Carleton (UBC: University of British Columbia)H-Index: 31
view all 9 authors...
Source
#1Neale Smith (UBC: University of British Columbia)H-Index: 14
#2Anne Smith (UBC: University of British Columbia)H-Index: 6
Last.Bruce Carleton (UBC: University of British Columbia)H-Index: 31
view all 10 authors...
2 CitationsSource
#1Laura Smy (U of T: University of Toronto)H-Index: 2
#2Kaitlyn Shaw (UBC: University of British Columbia)H-Index: 5
Last.Gideon Koren (U of T: University of Toronto)H-Index: 86
view all 7 authors...
Background Cortisol is a hormone involved in many physiological functions including fetal maturation and epigenetic programming during pregnancy. This study aimed to use hair cortisol as a biomarker of chronic inhaled corticosteroid (ICS) exposure and assess the potential effects of asthma on the hypothalamic-pituitary-adrenal (HPA) axis in pregnant women. We hypothesized that pregnant women with asthma treated with ICS would exhibit lower hair cortisol concentrations, indicative of adrenal supp...
5 CitationsSource
#1Kaitlyn ShawH-Index: 5
#2Ursula AmstutzH-Index: 18
Last.Bruce CarletonH-Index: 31
view all 10 authors...
OBJECTIVE To systematically review evidence on genetic variants influencing outcomes during warfarin therapy and provide practice recommendations addressing the key questions: (1) Should genetic testing be performed in patients with an indication for warfarin therapy to improve achievement of stable anticoagulation and reduce adverse effects? (2) Are there subgroups of patients who may benefit more from genetic testing compared with others? (3) How should patients with an indication for warfarin...
20 CitationsSource
#1Laura SmyH-Index: 2
#2Kaitlyn ShawH-Index: 5
Last.Gideon KorenH-Index: 86
view all 8 authors...
Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children
13 CitationsSource
#1J W Lee (UBC: University of British Columbia)H-Index: 6
#2Folefac Aminkeng (UBC: University of British Columbia)H-Index: 10
Last.C J RossH-Index: 12
view all 7 authors...
The vast range of genetic diversity contributes to a wonderful array of human traits and characteristics. Unfortunately, a consequence of this genetic diversity is large variability in drug response between people, meaning that no single medication is safe and effective in everyone. The debilitating and sometimes deadly consequences of adverse drug reactions (ADRs) are a major and unmet problem of modern medicine. Pharmacogenomics can uncover associations between genetic variation and drug safet...
40 CitationsSource
#1Kaitlyn Shaw (UBC: University of British Columbia)H-Index: 5
#2Ursula Amstutz (UBC: University of British Columbia)H-Index: 18
Last.Bruce Carleton (UBC: University of British Columbia)H-Index: 31
view all 10 authors...
BACKGROUND Despite substantial evidence supporting a pharmacogenetic approach to warfarin therapy in adults, evidence on the importance of genetics in warfarin therapy in children is limited, particularly for clinical outcomes. We assessed the contribution of CYP2C9/VKORC1/CYP4F2 genotypes and variation in other genes involved in vitamin K and coagulation pathways to warfarin dose and related clinical outcomes in children. PROCEDURE Clinical and genetic data for 93 children (age ≤ 18 years) who ...
29 CitationsSource
#1Kaitlyn Shaw (UBC: University of British Columbia)H-Index: 5
#2Ursula Amstutz (UBC: University of British Columbia)H-Index: 18
Last.Bruce Carleton (UBC: University of British Columbia)H-Index: 31
view all 12 authors...
Background The impact of genetic factors on the risk of adverse drug reactions (ADRs) is being increasingly recognized as clinically important. ADR Prioritization Tool (APT) was developed to facilitate the prioritization of drugs and their associated ADRs for future pharmacogenomic studies. Objectives To describe a novel tool developed for the prioritization of pharmacogenomic investigation of ADRs and discuss the impact of specific scoring criteria. Methods APT scores were based on 25 key scien...
5 Citations
#1Kaitlyn ShawH-Index: 5
#2Ursula AmstutzH-Index: 18
Last.Bruce CarletonH-Index: 31
view all 5 authors...
A 14-year-old female with suspected narcotic overdose had CYP2D6 genotyping performed to verify opiate intoxication. The role of pharmacogenetics in pain management and individualization of opiate pharmacotherapy is discussed.
5 CitationsSource
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