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João Palermo-Neto
University of São Paulo
EndocrinologyImmunologyMedicineBiologyImmune system
275Publications
30H-index
3,213Citations
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Publications 285
Newest
#1Wesley Nogueira Brandão (USP: University of São Paulo)H-Index: 7
#2Monica L. Andersen (UNIFESP: Federal University of São Paulo)H-Index: 33
Last. Adriano Zager (USP: University of São Paulo)H-Index: 12
view all 5 authors...
Abstract The psychostimulant drug modafinil has been used for many years for the treatment of sleep disorders. Recent studies have indicated that modafinil has immunomodulatory properties in the central nervous system (CNS) and peripheral immune cells. Thus, our aim was to determine the effects of in vivo therapeutic treatment with modafinil on the severity of clinical symptoms and immune response during the acute phase of experimental autoimmune encephalomyelitis (EAE), an experimental model of...
1 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 8
#2W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 13
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 12 authors...
Abstract Information on the dynamics of the chicken immune system during bacterial or parasite challenge in the presence or absence of stressful situations may provide a better understanding of the complex mechanisms behind these diseases. Necrotic enteritis (NE) had been controlled previously by the proper use of antimicrobial agents; however, more recently, NE has reemerged in many countries. The imposed restrictions on antimicrobial use and/or the intensive productive programs implemented by ...
2 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 8
#2Catarina Augusta de Queiroz Nunes (USP: University of São Paulo)H-Index: 1
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 6 authors...
Abstract Heat stress has a relevant effect on animal health and productivity. Stress and environmental changes can contribute to disease development, such as avian necrotic enteritis (NE). The goal of this study was to analyze the effects of heat stress applied to broiler chickens in an experimental model of co-infection with Clostridium perfringens and Eimeria spp. Therefore, the current study was designed to analyze the effect of heat stress to broiler chickens in an experimental model of infe...
1 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 8
#2Juliana Garcia da Silva Fonseca (USP: University of São Paulo)H-Index: 4
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 9 authors...
Heat stress has been related to the impairment of behavioral and immunological parameters in broiler chickens. However, the literature is not clear on the involvement of neuroimmune interactions in a heat stress situation associated with bacterial and parasitic infections. The present study evaluated the production of monoamines and their metabolites in brain regions (rostral pallium, hypothalamus, brain stem, and midbrain) in broiler chickens submitted to chronic heat stress and/or infection an...
1 CitationsSource
#1Talita Rossetto Barreto (USP: University of São Paulo)H-Index: 1
#2Carolina Costola-de-Souza (USP: University of São Paulo)H-Index: 6
Last. Adriano Zager (USP: University of São Paulo)H-Index: 12
view all 8 authors...
Abstract The dopaminergic antagonist drug Domperidone has immunomodulatory effects. We investigated the effects of repeated Domperidone treatment in a model of Lypopolyssacharide (LPS)-induced acute lung inflammation. Adult C57BL/6J mice were treated with either Vehicle or Domperidone for 5 days, and challenged intranasally with LPS in the following day. The behavior of mice was analyzed in the open field and elevated plus-maze test before and 24 h after LPS challenge. The bronchoalveolar lavage...
6 CitationsSource
#1Adriano Zager (USP: University of São Paulo)H-Index: 12
#2Wesley Nogueira Brandão (USP: University of São Paulo)H-Index: 7
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 8 authors...
Abstract The wake-promoting drug Modafinil has been used for many years for treatment of Narcolepsy and Excessive Daytime Sleepiness, due to a dopamine-related psychostimulant action. Recent studies have indicated that Modafinil prevents neuroinflammation in animal models. Thus, the aim of the present study was to evaluate the effect of Modafinil pretreatment in the Lipopolysaccharide (LPS)-induced sickness and depressive-like behaviors. Adult male C57BL/6J mice were pretreated with Vehicle or M...
10 CitationsSource
#1Adriano Zager (USP: University of São Paulo)H-Index: 12
#2Wesley Nogueira Brandão (USP: University of São Paulo)H-Index: 7
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 12 authors...
Abstract The wake-promoting drug Modafinil has been used for treatment of sleep disorders, such as Narcolepsy, excessive daytime sleepiness and sleep apnea, due to its stimulant action. Despite the known effect of Modafinil on brain neurochemistry, particularly on brain dopamine system, recent evidence support an immunomodulatory role for Modafinil treatment in neuroinflammatory models. Here, we aimed to study the effects of in vitro and in vivo Modafinil treatment on activation, proliferation, ...
4 CitationsSource
PURPOSE: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung's allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. METHODS: To induce hyperprol...
Source
#1Eduardo Kenji Hamasato (USP: University of São Paulo)H-Index: 1
#2Dennis F. Lovelock (Binghamton University)H-Index: 6
Last. Terrence Deak (Binghamton University)H-Index: 40
view all 4 authors...
Abstract Acute illness not only reduces the expression of social behavior by sick rodents, but can also lead to avoidance responses when detected by healthy, would-be social partners. When healthy animals interact with a sick partner, an intriguing question arises: does exposure to a sick conspecific elicit an anticipatory immune response that would facilitate defense against future infection? To address this question, healthy adult male Sprague-Dawley rats ( N = 64) were given a brief social in...
6 CitationsSource
#1Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 8
#2W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 13
Last. João Palermo-Neto (USP: University of São Paulo)H-Index: 30
view all 4 authors...
The intensification of poultry production has favoured the occurrence of stressful conditions such as infections, decreased feed intake, reduced feed conversion and carcass condemnation are some of the consequences of stress in birds. This stress is a consequence of the neuroendocrine-immune interplay. Neuroimmunomodulation is the scientific study of the bidirectional relation of the immune and nervous systems, i.e. , physiological effects in response to exposure of animals to stressful conditio...
6 CitationsSource
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