Match!
Yury Popov
Harvard University
99Publications
28H-index
2,648Citations
Publications 98
Newest
#1Guangyan Wei (SYSU: Sun Yat-sen University)H-Index: 1
#2Ping An (BIDMC: Beth Israel Deaconess Medical Center)
Last.Yury Popov (Harvard University)H-Index: 28
view all 9 authors...
Progressive fibrosis, liver failure and cancer are central liver-related outcomes of nonalcoholic steatohepatitis (NASH), but notoriously difficult to achieve in mouse models. We performed a direct...
Source
#1Sonja Rothweiler (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
#2Linda Feldbrügge (Humboldt University of Berlin)H-Index: 9
Last.Simon C. Robson (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 77
view all 9 authors...
Purinergic signaling is important in the activation and differentiation of macrophages, which play divergent roles in the pathophysiology of liver fibrosis. The ectonucleotidase CD39 is known to modulate the immunoregulatory phenotype of macrophages, but whether this specifically impacts cholestatic liver injury is unknown. Here, we investigated the role of macrophage-expressed CD39 on the development of biliary injury and fibrosis in a mouse model of sclerosing cholangitis. Myeloid-specific CD3...
2 CitationsSource
#1Hisayuki Amano (BCM: Baylor College of Medicine)H-Index: 2
#2Arindam Chaudhury (BCM: Baylor College of Medicine)H-Index: 11
Last.Ergun Sahin (BCM: Baylor College of Medicine)H-Index: 12
view all 19 authors...
Summary Telomere shortening is associated with stem cell decline, fibrotic disorders, and premature aging through mechanisms that are incompletely understood. Here, we show that telomere shortening in livers of telomerase knockout mice leads to a p53-dependent repression of all seven sirtuins. P53 regulates non-mitochondrial sirtuins (Sirt1, 2, 6, and 7) post-transcriptionally through microRNAs (miR-34a, 26a, and 145), while the mitochondrial sirtuins (Sirt3, 4, and 5) are regulated in a peroxis...
4 CitationsSource
#1Yong Ook Kim (University of Mainz)H-Index: 11
#2K.-S. Park (University of Mainz)
Last.Detlef Schuppan (University of Mainz)H-Index: 63
view all 7 authors...
Source
#1Yong Ook KimH-Index: 11
Last.Detlef SchuppanH-Index: 58
view all 7 authors...
Source
#1Linda Feldbrügge (Humboldt University of Berlin)H-Index: 9
#2Z. Gordon Jiang (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 14
Last.Simon C. Robson (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 77
view all 12 authors...
Ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) are cell surface-located transmembrane ecto-enzymes of the CD39 superfamily which regulate inflammation and tissue repair by catalyzing the phosphohydrolysis of extracellular nucleotides and modulating purinergic signaling. In the liver, NTPDase2 is reportedly expressed on portal fibroblasts, but its functional role in regulating tissue regeneration and fibrosis is incompletely understood. Here, we studied the role of NTPDase2 in seve...
4 CitationsSource
#1Zhen-Wei Peng (Harvard University)H-Index: 3
#2Sonja Rothweiler (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
Last.Yury Popov (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 28
view all 11 authors...
The pathogenesis of primary sclerosing cholangitis (PSC) and the mechanistic link to inflammatory bowel disease remain ill-defined. Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1)/clusters of differentiation (CD) 39, the dominant purinergic ecto-enzyme, modulates intestinal inflammation. Here, we have explored the role of CD39 in biliary injury and fibrosis. The impact of CD39 deletion on disease severity was studied in multidrug resistance protein 2 (Mdr2)–/– and 3,5-diethoxycarbonyl-...
6 CitationsSource
#1Naoki Ikenaga (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 18
#2Zhen-Wei Peng (SYSU: Sun Yat-sen University)H-Index: 3
Last.Yury Popov (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 28
view all 10 authors...
Background/Aims We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of a LOXL2-blocking monoclonal antibody on liver fibrosis progression/reversal in mice. Methods Anti-LOXL2 antibody, control antilysyl oxidase antibody or placebo was administered during thioacetamide (TAA)-induced fibrosis progression or during recovery. Therapeutic efficacy in biliary fibrosis was tested in BALB/c. Mdr2−/− ...
87 CitationsSource
#1Yong Ook Kim (University of Mainz)H-Index: 11
#2Yury Popov (Harvard University)H-Index: 28
Last.Detlef Schuppan (Harvard University)H-Index: 20
view all 3 authors...
12 CitationsSource
#1Michel FaustherH-Index: 16
Last.Kim R. BridleH-Index: 18
view all 4 authors...
3 CitationsSource
12345678910