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Michelle Lai
Beth Israel Deaconess Medical Center
Physical therapyNonalcoholic fatty liver diseaseFibrosisDiabetes mellitusMedicine
99Publications
20H-index
1,709Citations
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Publications 98
Newest
#1Christopher J. Danford (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Jennifer Y. Lee (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Michelle Lai (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
view all 5 authors...
BACKGROUND AND AIMS Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS We used Clinical Query 2, a search tool at Beth Israel Deaconess Medical Center, to create a pool of potential NASH cirrhosis cases (n = 5415). We created a training set of 300 ran...
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#1Ping An (WHU: Wuhan University)H-Index: 1
#2Lin-Lin Wei (Capital Medical University)
Last. Yury Popov (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 30
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Due to their bacterial ancestry, many components of mitochondria share structural similarities with bacteria. Release of molecular danger signals from injured cell mitochondria (mitochondria-derived damage-associated molecular patterns, mito-DAMPs) triggers a potent inflammatory response, but their role in fibrosis is unknown. Using liver fibrosis resistant/susceptible mouse strain system, we demonstrate that mito-DAMPs released from injured hepatocyte mitochondria (with mtDNA as major active co...
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#1Ghideon Ezaz (ISMMS: Icahn School of Medicine at Mount Sinai)
#2Hirsh D. Trivedi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Nezam H. Afdhal (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 73
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Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease driven by genetic and environmental factors. MicroRNAs (miRNAs) serve as pleiotropic post-transcriptional regulators of cellular pathways. Although several miRNAs have been associated with NAFLD and fibrosis, there are limited studies in humans examining their differential association with pathogenic factors or histological features of NAFLD. We examined the differential relationships of five of the best-described circulating mi...
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#1Michelle LaiH-Index: 20
Last. Nezam H. AfdhalH-Index: 73
view all 9 authors...
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#1Vijay K. Venkatraman (University of Melbourne)H-Index: 15
#2Andrew Sanderson (University of Melbourne)H-Index: 1
Last. Patricia Desmond (University of Melbourne)H-Index: 61
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Abstract White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acqu...
3 CitationsSource
#1Michelle LaiH-Index: 20
Last. Nezam H. AfdhalH-Index: 73
view all 9 authors...
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#2Jaspreet SuriH-Index: 1
Last. Michelle LaiH-Index: 20
view all 9 authors...
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#1Michelle LaiH-Index: 20
Last. Nezam H. AfdhalH-Index: 73
view all 9 authors...
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#1Michelle LaiH-Index: 20
Last. Nezam H. AfdhalH-Index: 73
view all 9 authors...
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#1Michelle LaiH-Index: 20
Last. Nezam H. AfdhalH-Index: 73
view all 7 authors...
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