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Alexander J. Malkin
Lawrence Livermore National Laboratory
48Publications
22H-index
1,367Citations
Publications 48
Newest
Last.Terrance J. Leighton (Children's Hospital Oakland Research Institute)H-Index: 14
view all 7 authors...
Abstract Recently, global public health organizations such as Doctors without Borders (MSF), the World Health Organization (WHO), Public Health Canada, National Institutes of Health (NIH), and the U.S. government developed and deployed Field Decontamination Kits (FDKs), a novel, lightweight, compact, reusable decontamination technology to sterilize Ebola-contaminated medical devices at remote clinical sites lacking infra-structure in crisis-stricken regions of West Africa (medical waste material...
#1Marco Plomp (LLNL: Lawrence Livermore National Laboratory)H-Index: 15
#2Alicia Monroe Carroll (University of Connecticut Health Center)H-Index: 2
Last.Alexander J. Malkin (LLNL: Lawrence Livermore National Laboratory)H-Index: 22
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Bacillus spores are encased in a multilayer, proteinaceous self-assembled coat structure that assists in protecting the bacterial genome from stresses and consists of at least 70 proteins. The elucidation of Bacillus spore coat assembly, architecture, and function is critical to determining mechanisms of spore pathogenesis, environmental resistance, immune response, and physicochemical properties. Recently, genetic, biochemical and microscopy methods have provided new insight into spore coat arc...
#1Christopher J. Doona (DA: United States Department of the Army)H-Index: 13
#2Florence E. Feeherry (DA: United States Department of the Army)H-Index: 9
Last.Terrence J. Leighton (Children's Hospital Oakland Research Institute)H-Index: 1
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There is a stated Army need for a field-portable, non-steam sterilizer technology that can be used by Forward Surgical Teams, Dental Companies, Veterinary Service Support Detachments, Combat Support Hospitals, and Area Medical Laboratories to sterilize surgical instruments and to sterilize pathological specimens prior to disposal in operating rooms, emergency treatment areas, and intensive care units. The following ensemble of novel, ‘clean and green’ chlorine dioxide technologies are versatile ...
#1Catherine I. Lacayo (LLNL: Lawrence Livermore National Laboratory)H-Index: 3
#2Alexander J. Malkin (LLNL: Lawrence Livermore National Laboratory)H-Index: 22
Last.Michael P. Thelen (Joint BioEnergy Institute)H-Index: 2
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The chemical and structural organization of the plant cell wall was examined in Zinnia elegans tracheary elements (TEs), which specialize by developing prominent secondary wall thickenings underlying the primary wall during xylogenesis in vitro. Three imaging platforms were used in conjunction with chemical extraction of wall components to investigate the composition and structure of single Zinnia TEs. Using fluorescence microscopy with a green fluorescent protein-tagged Clostridium thermocellum...
#1Alexander J. Malkin (LLNL: Lawrence Livermore National Laboratory)H-Index: 22
#2Marco Plomp (LLNL: Lawrence Livermore National Laboratory)H-Index: 15
One of the great scientific challenges at the intersection of chemistry, biology and materials science is to define the biophysical pathways of cellular life, and in particular, to elucidate the complex molecular machines that carry out cellular and microbial function and propagate the disease. To study this in a comprehensive way, the fundamental understanding of the principal mechanisms by which cellular systems are ultimately linked with their chemical, physical, and biological environment ar...
#1Sonali GhoshH-Index: 12
#2Barbara SetlowH-Index: 43
Last.Peter SetlowH-Index: 74
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Spores of Bacillus subtilis have a thick outer layer of relatively insoluble protein called the coat, which protects spores against a number of treatments and may also play roles in spore germination. However, elucidation of precise roles of the coat in spore properties has been hampered by the inability to prepare spores lacking all or most coat material. In this work, we show that spores of a strain with mutations in both the cotE and gerE genes, which encode proteins involved in coat assembly...
The gram-positive bacterium Bacillus subtilis forms remarkably resistant endospores when it is faced with starvation (36). This process, known as sporulation, produces metabolically dormant spores that are resistant to heat, radiation, and desiccation, as well as to predation by the protozoan Tetrahymena thermophila (17, 26, 36). These spores remain dormant until they sense that nutrients are available, at which time they can undergo germination and outgrowth to change back into growing cells (3...
#1Alexander J. MalkinH-Index: 22
#2Marco PlompH-Index: 15
Last.Katherine E. WheelerH-Index: 10
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Complete genome sequences are available for understanding biotransformation, environmental resistance and pathogenesis of microbial, cellular and pathogen systems. The present technological and scientific challenges are to unravel the relationships between the organization and function of protein complexes at cell, microbial and pathogens surfaces, to understand how these complexes evolve during the bacterial, cellular and pathogen life cycles, and how they respond to environmental changes, chem...
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