Weihong Tang
University of Minnesota
Genome-wide association studyGeneticsDiabetes mellitusMedicineBiology
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Publications 206
#1David Stacey (University of Cambridge)H-Index: 4
#2Lingyan Chen (University of Cambridge)
Last. Neda Farahi (University of Cambridge)H-Index: 12
view all 25 authors...
Genome-wide association studies have identified many individual genetic loci associated with multiple complex traits and common diseases. There are, however, few examples where the molecular basis of such pleiotropy has been elucidated. To address this challenge, we describe an integrative approach, focusing on the p.Ser219Gly (rs867186 A>G) variant in the PROCR gene (encoding the endothelial protein C receptor, EPCR), which has been associated with lower coronary artery disease (CAD) risk but h...
#1Chani J. Hodonsky (UVA: University of Virginia)H-Index: 6
#1Hodonsky Cj (UVA: University of Virginia)
Last. Weihong Tang (UMN: University of Minnesota)H-Index: 32
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BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variation contributes substantially to RBC trait heritability. Recently developed combined-phenotype methods which leverage genetic trait correlation to improve statistical power have not yet been applied to...
#1Ning Ding (Johns Hopkins University)H-Index: 2
#2Yingying Sang (Johns Hopkins University)H-Index: 23
Last. Kunihiro Matsushita (Johns Hopkins University)H-Index: 50
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#1Weihong Tang (UMN: University of Minnesota)H-Index: 32
#2Mary Rachel Stimson (UMN: University of Minnesota)H-Index: 1
Last. Nathan Pankratz (UMN: University of Minnesota)H-Index: 38
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BACKGROUND: Rare coding mutations underlying deficiencies of antithrombin and proteins C and S contribute to familial venous thromboembolism (VTE). It is uncertain whether rare variants play a role in the etiology of VTE in the general population. OBJECTIVES: We conducted a deep whole-exome sequencing (WES) study to investigate the associations between rare coding variants and the risk of VTE in two population-based prospective cohorts. PATIENTS/METHODS: Whole-exome sequencing was performed in t...
1 CitationsSource
#1Weihong Tang (UMN: University of Minnesota)H-Index: 32
#2Athanasios Saratzis (University of Leicester)H-Index: 21
Last. Matthew J. Bown (University of Leicester)H-Index: 36
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Objective A recently published genome wide association study of abdominal aortic aneurysms (AAA), based on pooled case control data of European ancestry, identified four new loci for AAA: SMYD2 (top single nucleotide polymorphism [SNP] rs1795061), LINC00540 (rs9316871), PCIF1/MMP9/ZNF335 (rs3827066), and ERG (rs2836411). Of the four, rs1795061 and rs2836411 showed significant heterogeneity across studies and the p value for rs9316871 did not reach the genome wide significance threshold until dis...
#1Sara Lindstroem (UW: University of Washington)H-Index: 46
#2Lu Wang (UW: University of Washington)H-Index: 1
Last. Nicholas L. Smith (UW: University of Washington)H-Index: 57
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Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To advance our understanding of the biology contributing to VTE, we conducted a genome-wide association study (GWAS) of VTE and a transcriptome-wide association study (TWAS) based on imputed gene expression from whole blood and liver. We meta-analyzed GWAS data from 18 studies for 30,234 VTE cases and 172,122 controls and assessed the association between 12,923,718 genetic variants and VTE. We generated variant...
3 CitationsSource
#1Jingjing Liang (Case Western Reserve University)H-Index: 8
#2Brian E. Cade (Broad Institute)H-Index: 20
Last. Xiaofeng Zhu (Case Western Reserve University)H-Index: 4
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Average arterial oxyhemoglobin saturation during sleep (AvSpO2S) is a clinically relevant measure of physiological stress associated with sleep-disordered breathing, and this measure predicts incident cardiovascular disease and mortality. Using high-depth whole-genome sequencing data from the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) project and focusing on genes with linkage evidence on chromosome 8p23, 1 , 2 we observed that six coding and 51...
#1Romil Parikh (UMN: University of Minnesota)H-Index: 1
#2Aaron R. Folsom (UMN: University of Minnesota)H-Index: 159
Last. M. Cushrnan (UVM: University of Vermont)H-Index: 108
view all 7 authors...
Abstract Introduction High molecular weight kininogen (HK) and prekallikrein (PK) are proteins in the kallikrein/kinin system of the coagulation cascade. They play an important role in the contact activation system of the intrinsic coagulation pathway, renin-angiotensin activation, and inflammation. Hence these proteins have been posited to affect the occurrence of cardiovascular events and thus to be potential therapeutic targets. Previous case-control studies have provided inconsistent evidenc...
#2Paul S. de VriesH-Index: 15
Last. Alanna C. MorrisonH-Index: 44
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textabstractBackground Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, pleiotropy robust MR methodologies. Methods and findings We evaluated evidence for a causal effect of fibri...
#1Daniel Taliun (UM: University of Michigan)H-Index: 13
#2Daniel N. Harris (UMB: University of Maryland, Baltimore)H-Index: 4
Last. Gonçalo R. Abecasis (UM: University of Michigan)H-Index: 144
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Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, and sleep disorders, with the ultimate goal of improving diagnosis, treatment, and prevention. The initial phases of the program focus on whole genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here, we describe TOPMed goals and design as well as resources and early insights from the sequence data. The r...
24 CitationsSource