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Weihong Tang
University of Minnesota
177Publications
30H-index
2,983Citations
Publications 177
Newest
#1Romil Parikh (UMN: University of Minnesota)
#2Aaron R. Folsom (UMN: University of Minnesota)H-Index: 155
Last.M. Cushrnan (UVM: University of Vermont)H-Index: 103
view all 7 authors...
Abstract Introduction High molecular weight kininogen (HK) and prekallikrein (PK) are proteins in the kallikrein/kinin system of the coagulation cascade. They play an important role in the contact activation system of the intrinsic coagulation pathway, renin-angiotensin activation, and inflammation. Hence these proteins have been posited to affect the occurrence of cardiovascular events and thus to be potential therapeutic targets. Previous case-control studies have provided inconsistent evidenc...
#1Abayomi O. Oyenuga (UMN: University of Minnesota)H-Index: 1
#2Aaron R. Folsom (UMN: University of Minnesota)H-Index: 10
Last.Weihong Tang (UMN: University of Minnesota)H-Index: 30
view all 4 authors...
To optimize cardiovascular health, the American Heart Association (AHA) has recommended ‘Life’s Simple 7 (LS7)’. We tested the hypothesis that greater adherence to the LS7 cardiovascular risk metric is associated with reduced risk of developing abdominal aortic aneurysm (AAA). A total of 14,375 black and white participants aged 45–64 years at the baseline visit of the Atherosclerosis Risk in Communities (ARIC) study cohort were included in this analysis. A 14-point summary score for LS7 was calc...
#2Paul S. de VriesH-Index: 14
Last.Tim KacprowskiH-Index: 16
view all 58 authors...
textabstractBackground Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, pleiotropy robust MR methodologies. Methods and findings We evaluated evidence for a causal effect of fibri...
#1Aaron R. Folsom (UMN: University of Minnesota)H-Index: 155
#2Aaron R. Folsom (UMN: University of Minnesota)H-Index: 10
Last.M. Cushrnan (UVM: University of Vermont)H-Index: 103
view all 7 authors...
The kallikrein/kinin system, an intravascular biochemical pathway that includes several proteins involved in the contact activation system of coagulation, renin–angiotensin activation and inflammation, may or may not play a role in venous thromboembolism (VTE) occurrence. Within a large prospective population-based study in the United States, we conducted a nested case–cohort study to test the hypothesis that higher plasma levels of high molecular weight kininogen (HK) or prekallikrein are assoc...
#1Daniel Taliun (UM: University of Michigan)H-Index: 12
#2Daniel N. Harris (UMB: University of Maryland, Baltimore)H-Index: 4
Last.Stephanie M. Gogarten (UW: University of Washington)H-Index: 23
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The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, and sleep disorders, with the ultimate goal of improving diagnosis, treatment, and prevention. The initial phases of the program focus on whole genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here, we describe TOPMed goals and design as well as resources and early insights from the sequence data. The resources include a...
#1Paul S. de Vries (University of Texas Health Science Center at Houston)H-Index: 14
#2Maria Sabater-Lleal (Karolinska University Hospital)H-Index: 19
Last.Graciela Delgado (Heidelberg University)H-Index: 21
view all 45 authors...
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combin...
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