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Xuehong Zhang
Brigham and Women's Hospital
CancerOncologyProspective cohort studyColorectal cancerMedicine
161Publications
28H-index
2,242Citations
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Publications 172
Newest
#1Joyce Y. Huang (University of Pittsburgh)H-Index: 4
#2Tricia L Larose (IARC: International Agency for Research on Cancer)H-Index: 9
Last. Jian-Min Yuan (University of Pittsburgh)H-Index: 72
view all 54 authors...
Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case–control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based m...
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#1Koichiro Haruki (Brigham and Women's Hospital)
#2Keisuke Kosumi (Brigham and Women's Hospital)
Last. Kenji Fujiyoshi (Brigham and Women's Hospital)
view all 26 authors...
Histological lymphocytic reaction is regarded as an independent prognostic marker in colorectal cancer. Considering the lack of adequate statistical power, adjustment for selection bias and comprehensive tumour molecular data in most previous studies, we investigated the strengths of the prognostic associations of lymphocytic reaction in colorectal carcinoma by utilising an integrative database of two prospective cohort studies. We examined Crohn’s-like reaction, intratumoural periglandular reac...
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#1Wanshui Yang (Anhui Medical University)H-Index: 3
#2Jing Sui (SEU: Southeast University)H-Index: 2
Last. Xuehong Zhang (Brigham and Women's Hospital)H-Index: 28
view all 10 authors...
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#1Daniela Schmid (University of Freiburg)
#2Mingyang SongH-Index: 27
Last. Karin B. Michels (University of Freiburg)H-Index: 62
view all 7 authors...
BACKGROUND: Although a link between regular yogurt consumption and mortality appears plausible, data are sparse and have yielded inconsistent results. OBJECTIVES: We examined the association between regular yogurt consumption and risk of all-cause and cause-specific mortality among US women and men. METHODS: A total of 82,348 women in the Nurses' Health Study and 40,278 men in the Health Professionals Follow-Up Study without a history of cardiovascular disease (CVD) and cancer in 1980 (women) or...
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#1Jae Jeong Yang (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Danxia Yu (VUMC: Vanderbilt University Medical Center)H-Index: 16
Last. Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 100
view all 24 authors...
Importance Dietary fiber (the main source of prebiotics) and yogurt (a probiotic food) confer various health benefits via modulating the gut microbiota and metabolic pathways. However, their associations with lung cancer risk have not been well investigated. Objective To evaluate the individual and joint associations of dietary fiber and yogurt consumption with lung cancer risk and to assess the potential effect modification of the associations by lifestyle and other dietary factors. Design, Set...
1 CitationsSource
#1Koichiro Haruki (Jikei University School of Medicine)
#2Keisuke Kosumi (Brigham and Women's Hospital)
Last. Shuji OginoH-Index: 85
view all 32 authors...
Fusobacterium nucleatum (F. nucleatum), which has been associated with colorectal carcinogenesis, can impair anti-tumour immunity, and actively invade colon epithelial cells. Considering the critical role of autophagy in host defence against microorganisms, we hypothesised that autophagic activity of tumour cells might influence the amount of F. nucleatum in colorectal cancer tissue. Using 724 rectal and colon cancer cases within the Nurses' Health Study and the Health Professionals Follow-up St...
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#1Mohammad Abufaraj (Medical University of Vienna)H-Index: 8
#2Shahrokh F. Shariat (Medical University of Vienna)H-Index: 96
Last. Eva S. Schernhammer (Medical University of Vienna)H-Index: 55
view all 10 authors...
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#1Tracey G. Simon (Harvard University)H-Index: 10
#2Mi Na Kim (Harvard University)
Last. Andrew T. ChanH-Index: 80
view all 14 authors...
Abstract Background & Aims Obesity in adulthood has been associated with increased risk of liver-related mortality. Whether higher levels of physical activity counteract the excess risk conferred by obesity remains unknown. We simultaneously evaluated the long-term impact of physical activity and adiposity on liver-related mortality, within two nationwide populations. Methods We conducted a prospective cohort study of 77,238 women and 48,026 men, with detailed, validated assessments of weekly ph...
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#1Wanshui Yang (Anhui Medical University)H-Index: 3
#2Edward Giovannucci (Harvard University)H-Index: 180
Last. Xuehong Zhang (Harvard University)H-Index: 28
view all 11 authors...
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#1Wanshui Yang (Anhui Medical University)H-Index: 3
#2Jing Sui (SEU: Southeast University)H-Index: 2
Last. Xuehong Zhang (Harvard University)H-Index: 28
view all 11 authors...
Abstract Background & Aims We investigated associations of intake of total fats, specific dietary fats, and fats from different food sources with risk of hepatocellular carcinoma (HCC) using data from the Nurses’ Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Methods We analyzed data from a total of 138,483 women and men who participated in the NHS or HPFS. A validated semi-quantitative food frequency questionnaire was sent to NHS participants in 1980, 1984, 1986, and ev...
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