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Donald E. Richards
Norwich University
20Publications
13H-index
3,533Citations
Publications 20
Newest
#1Xiangdong Fu (Norwich University)H-Index: 28
#2Donald E. Richards (Norwich University)H-Index: 13
Last.Nicholas P. Harberd (Norwich University)H-Index: 47
view all 6 authors...
DELLA proteins restrain the cell proliferation and enlargement that characterizes the growth of plant organs. Gibberellin stimulates growth via 26S proteasome–dependent destruction of DELLAs, thus relieving DELLA-mediated growth restraint. Here, we show that the Arabidopsis thaliana sleepy1 gar2-1 ( sly1 gar2-1 ) mutant allele encodes a mutant subunit (sly1 gar2-1 ) of an SCF SLY1 E3 ubiquitin ligase complex. SLY1 (the wild-type form) and sly1 gar2-1 both confer substrate specificity on this com...
#1Hui ChengH-Index: 7
#2Lianju QinH-Index: 1
Last.Jinrong PengH-Index: 33
view all 9 authors...
The phytohormone gibberellin (GA) regulates the development and fertility of Arabidopsis flowers. The mature flowers of GA-deficient mutant plants typically exhibit reduced elongation growth of petals and stamens. In addition, GA-deficiency blocks anther development, resulting in male sterility. Previous analyses have shown that GA promotes the elongation of plant organs by opposing the function of the DELLA proteins, a family of nuclear growth repressors. However, it was not clear that the DELL...
#1Llewelyn W. Hynes (JIC: John Innes Centre)H-Index: 2
#2Jinrong Peng (JIC: John Innes Centre)H-Index: 33
Last.Nicholas P. Harberd (JIC: John Innes Centre)H-Index: 47
view all 4 authors...
Bioactive gibberellin (GA) regulates the growth and development of a wide array of plant species. GA exerts its effects via members of the DELLA protein family of putative transcriptional regulators. The GAI gene encodes GAI, a DELLA protein from Arabidopsis thaliana (L.) Heyhn. A mutant allele, gai, encodes a mutant protein (gai) that has altered properties, and confers a dominant, reduced GA-response, dwarf phenotype. Here we describe experiments to investigate the effects of transgenic expres...
#1Xiangdong Fu (JIC: John Innes Centre)H-Index: 28
#2Donald E. Richards (Norwich University)H-Index: 13
Last.Nicholas P. Harberd (Norwich University)H-Index: 47
view all 7 authors...
DELLA proteins are nuclear repressors of plant gibberellin (GA) responses. Here, we investigate the properties of SLN1, a DELLA protein from barley that is destabilized by GA treatment. Using specific inhibitors of proteasome function, we show that proteasome-mediated protein degradation is necessary for GA-mediated destabilization of SLN1. We also show that GA responses, such as the aleurone α-amylase response and seedling leaf extension growth, require proteasome-dependent GA-mediated SLN1 des...
#1Jinrong Peng (JIC: John Innes Centre)H-Index: 33
#2Donald E. Richards (JIC: John Innes Centre)H-Index: 13
Last.Nicholas P. Harberd (JIC: John Innes Centre)H-Index: 47
view all 6 authors...
Bioactive gibberellin (GA) is an essential regulator of vascular plant development. The GAI gene of Arabidopsis thaliana (L.) Heynh. encodes a product (GAI) that is involved in GA signalling. The dominant mutant gai allele encodes an altered product (gai) that confers reduced GA responses, dwarfism, and elevated endogenous GA levels. Recessive, presumed loss-of-function alleles of GAI confer normal height and resistance to the GA biosynthesis inhibitor paclobutrazol. One explanation for these ob...
#1Xiangdong Fu (Norwich Research Park)H-Index: 28
#2Duraialagaraja Sudhakar (Norwich Research Park)H-Index: 11
Last.Nicholas P. Harberd (Norwich Research Park)H-Index: 47
view all 6 authors...
Bioactive gibberellins (GAs) are essential endogenous regulators of plant growth. GA signaling is mediated via GAI, a nuclear member of the GRAS family of plant transcription factors. Previous experiments have suggested that GAI is a GA-derepressible repressor of plant growth. Here we test this hypothesis by examining the effects of the expression of Arabidopsis GAI in transgenic Basmati rice. High-level expression of GAI caused dwarfism and reduced GA responses, and the strength of this effect ...
#1Donald E. Richards (JIC: John Innes Centre)H-Index: 13
#2Kathryn E. KingH-Index: 5
Last.Nicholas P. HarberdH-Index: 47
view all 4 authors...
▪ Abstract Gibberellins are hormones that control growth and a wide variety of other plant developmental processes. In recent years, significant progress has been made on the biochemistry of gibberellin biosynthesis and on the mechanisms by which gibberellin levels are regulated in plants. There have also been major advances in the understanding of gibberellin signaling, with several key genes being cloned. This review discusses our current understanding of gibberellin signaling, as seen from th...
#1Donald E. Richards (JIC: John Innes Centre)H-Index: 13
#2Jinrong Peng (JIC: John Innes Centre)H-Index: 33
Last.Nicholas P. Harberd (JIC: John Innes Centre)H-Index: 47
view all 3 authors...
GRAS is a recently discovered family of plant-specific proteins that play important regulatory roles in diverse aspects of plant development. Several of the motifs present in the GRAS proteins suggest that they function as transcription factors, although homology-searching programs have revealed no significant similarity to any non-plant proteins. Here we propose that the GRAS proteins are related to the Signal Transducers and Activators of Transcription (STAT) family of proteins. STATs are know...
#1Jinrong PengH-Index: 33
#2Donald E. RichardsH-Index: 13
Last.Fatima Pelica (JIC: John Innes Centre)H-Index: 1
view all 15 authors...
World wheat grain yields increased substantially in the 1960s and 1970s because farmers rapidly adopted the new varieties and cultivation methods of the so-called ‘green revolution’1,2,3,4. The new varieties are shorter, increase grain yield at the expense of straw biomass, and are more resistant to damage by wind and rain3,4. These wheats are short because they respond abnormally to the plant growth hormone gibberellin. This reduced response to gibberellin is conferred by mutant dwarfing allele...
#1Jinrong PengH-Index: 33
#2Donald E. RichardsH-Index: 13
Last.Nicholas P. HarberdH-Index: 47
view all 5 authors...
Active gibberellins (GAs) are endogenous factors that regulate plant growth and development in a dose-dependent fashion. Mutant plants that are GA deficient, or exhibit reduced GA responses, display a characteristic dwarf phenotype. Extragenic suppressor analysis has resulted in the isolation of Arabidopsis mutations, which partially suppress the dwarf phenotype conferred by GA deficiency and reduced GA-response mutations. Here we describe detailed studies of the effects of two of these suppress...
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