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Etheresia Pretorius
Stellenbosch University
ImmunologyFibrinMedicineBiologyPlatelet
274Publications
33H-index
3,952Citations
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Publications 277
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#1Martin J. Page (Stellenbosch University)H-Index: 6
#2Etheresia Pretorius (Stellenbosch University)H-Index: 33
Thrombocytopenia is commonly associated with sepsis and infections, which in turn are characterized by a profound immune reaction to the invading pathogen. Platelets are one of the cellular entities that exert considerable immune, antibacterial, and antiviral actions, and are therefore active participants in the host response. Platelets are sensitive to surrounding inflammatory stimuli and contribute to the immune response by multiple mechanisms, including endowing the endothelium with a proinfl...
3 CitationsSource
#1Irina BorodinaH-Index: 24
#2Louise C. KennyH-Index: 44
Last. Douglas B. KellH-Index: 96
view all 8 authors...
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even...
1 CitationsSource
#1Maria J.E. Visser (Stellenbosch University)H-Index: 1
#2Etheresia Pretorius (Stellenbosch University)H-Index: 33
Proteins are versatile macromolecules that perform a variety of functions and participate in virtually all cellular processes. The functionality of a protein greatly depends on its structure and alterations may result in the development of disease states. Most well-known of these are protein misfolding disorders, which include Alzheimer's and Parkinson's diseases as well as type 2 diabetes mellitus, where soluble proteins transition into insoluble amyloid fibrils. Atomic force microscopy (AFM) i...
1 CitationsSource
#1J. Massimo Nunes (Stellenbosch University)H-Index: 1
#2Etheresia Pretorius (Stellenbosch University)H-Index: 33
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#1Sulette de Villiers (University of Pretoria)H-Index: 1
#2Janette Bester (University of Pretoria)H-Index: 14
Last. Etheresia Pretorius (Stellenbosch University)H-Index: 33
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Introduction: Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised by endothelial dysfunction. It is also well known that chronic inflammation results in an excessive burden of oxidative stress and therefore cellular dysfunction. In this study the effects of excessive oxidative stress through the phases of female migraine-with-aura (FMA) w...
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#1Marry-ann Ntanyane Phasha (University of Pretoria)
#2Prashilla Soma (University of Pretoria)H-Index: 12
Last. Alia Phulukdaree (University of Pretoria)
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#1Buin Adams (Stellenbosch University)H-Index: 1
#2J. Massimo Nunes (Stellenbosch University)H-Index: 1
Last. Etheresia Pretorius (Stellenbosch University)H-Index: 33
view all 8 authors...
Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipains protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of it’s presence in a PD population. We confirm previous findings regarding PD systemic inflammation via multiplex cytokine analysis, demonstrate hypercoagul...
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Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a dysregulated circulating inflammatory molecule tendency. T2DM is closely associated with systemic inflammation, endothelial dysfunction, cardiovascular risk, and increased clotting susceptibility. Platelets have fundamental roles in the development and propagation of inflammation and cardiovascular risk. They signal through membrane receptors, resulting in (hyper)activation and release of inflammatory molecules from platelet comp...
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#1Shehan N. Randeria (Stellenbosch University)
#2Greig J. A. Thomson (Stellenbosch University)H-Index: 2
Last. Etheresia Pretorius (Stellenbosch University)H-Index: 33
view all 5 authors...
Background The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.
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#1J. Massimo Nunes (Stellenbosch University)H-Index: 1
#2Etheresia Pretorius (Stellenbosch University)H-Index: 33
Abstract Type II diabetes mellitus (T2DM) affects an estimate of 450 million individuals. Hence, there remains an urgent need to explore the use of novel biomarkers with the aim of preventing and managing cardiovascular risk among these individuals. Hallmarks of this condition are lipid and glucose dyshomeostasis which are accompanied by a prothrombotic phenotype; these pose as eminent links between T2DM and cardiovascular disease. Diabetic dyslipidemia affects not only plasma lipid profiles but...
1 CitationsSource
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