Sébastien Thériault
Laval University
Publications 49
#1Mickael Rosa (Laval University)H-Index: 2
#2Arnaud Chignon (Laval University)
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 8 authors...
Growing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders. Cis-MR with multiple instrumental variables showed an inverse association of sIL6R with rheumatoid arthritis, atrial fibrillation, stroke, coronary artery disease, a...
1 CitationsSource
#1Sébastien Thériault (Laval University)H-Index: 12
#2Christian Dina (University of Nantes)H-Index: 15
Last.Jean-Jacques Schott (University of Nantes)H-Index: 43
view all 31 authors...
Background: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA a...
#1Evangelos Evangelou (Imperial College London)H-Index: 47
#2He Gao (Imperial College London)H-Index: 18
Last.Perry M. ElliottH-Index: 154
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Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We ide...
7 CitationsSource
#1Nicolas PerrotH-Index: 3
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#1Ioanna Ntalla (QMUL: Queen Mary University of London)H-Index: 28
#2Lu-Chen Weng (Harvard University)H-Index: 17
Last.Patricia B. Munroe (QMUL: Queen Mary University of London)H-Index: 74
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The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. We performed multi-ancestry (N=293,051) and European only (N=271,570) genome-wide association (GWAS) meta-analyses for the PR interval, discovering 210 loci of which 149 are novel. Variants at all loci nearly doubled the percentage of heritability explained, from 33.5% to 62.6%. We observed enri...
#1Nicolas Perrot (Laval University)H-Index: 3
#2Sébastien Thériault (Laval University)H-Index: 12
Last.Benoit J. Arsenault (Laval University)H-Index: 30
view all 26 authors...
Importance Genetic variants at theLPAlocus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. Objective To study the associations ofLPAvariants with CAVS in a cohort of patients undergoing heart surgery andLPAwith CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein...
#1Audrey-Anne Després (Laval University)
#2Nicolas Perrot (Laval University)H-Index: 3
Last.Benoit J. Arsenault (Laval University)H-Index: 30
view all 23 authors...
Abstract Background Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microca...
#1Benoit J. Arsenault (Laval University)H-Index: 30
#2William Pelletier (Laval University)
Last.S. Matthijs Boekholdt (UvA: University of Amsterdam)H-Index: 53
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BackgroundElevated Lipoprotein(a) (Lp[a]) levels are associated with a broad range of atherosclerotic cardiovascular diseases (CVD). The impact of high Lp(a) levels on human longevity is however controversial. Our objectives were to determine whether genetically-determined Lp(a) levels are associated with parental lifespan and to assess the association between measured and genetically-determined Lp(a) levels and long-term all-cause and cardiovascular mortality.nnMethodsWe determined the associat...
#1R. Mickael (Laval University)
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 12 authors...
Introduction Calcific aortic valve stenosis (CAVS) is the most common heart valve disorder. Genome and transcriptome-wide association studies identified risk variant rs6702619 at the PALMD locus as casually associated with CAVS and with lower PALMD expression. Objective To map and fine-grain molecular analyses to probe the regulation and function of PALMD. Methods Regulation of the PALMD risk locus and its impact on valve interstitial cells (VICs) were evaluated. Reporter assays, DNA-binding ass...
#1Nicolas PerrotH-Index: 3
#2Donato MoschettaH-Index: 2
Last.Benoit J. ArsenaultH-Index: 30
view all 21 authors...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition reduces plasma concentrations of low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)]. Atherogenic lipoprotein levels have been linked with calcific aortic valve stenosis (CAVS). Our objectives were to determine the association between variants in PCSK9 and lipoprotein-lipid levels, coronary artery disease (CAD) and CAVS, and to evaluate if PCSK9 could be implicated in aortic v...