Match!
Yuan Huang
Sichuan University
Organic chemistryChemistryMaterials scienceDrug deliveryBiochemistry
111Publications
22H-index
1,892Citations
What is this?
Publications 113
Newest
#1Lei Wu (Sichuan University)H-Index: 7
#2Yuli Bai (Sichuan University)H-Index: 1
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 10 authors...
Abstract The epithelium is a formidable barrier to the absorption of orally delivered nano-vehicles. Here, by exploring a nutrient-absorption pathway, a self-amplified nanoplatform was developed to promote apical-to-basolateral transcytosis across the epithelium. The nanoplatform consisted of fructose-modified polyethylene glycol coated nanoparticles (Fru-PEG NPs) and a sweetener, acesulfame potassium (AceK) in combination. Compared with regular PEGylated nanoparticles, the combination exhibited...
Source
#1Yuli BaiH-Index: 1
#2Rui ZhouH-Index: 2
Last. Yuan HuangH-Index: 22
view all 8 authors...
Surface features are key to the transcellular transport of nanoparticles (NPs) across intestinal epithelium cells. Endowing the NPs with specific surface features adapted to the physiological conditions of the gastrointestinal (GI) tract holds great potential for the oral delivery of peptide/protein drugs. Therefore, in this work, a glutamic acid conjugated amphiphilic dendrimer (Glu-APD) was synthesized to replace the widely used 1,2-distearoyl-sn-glycero-3-phosphatidyl-ethanolamine-polyethylen...
Source
#1Dandan Xie (Sichuan University)
#2Fengling Wang (Sichuan University)
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 4 authors...
Abstract Nucleus is the central regulator of cell metabolism, growth and differentiation, which is considered as an effective target for the treatment of many diseases. To efficiently deliver drugs into nucleus, delivery systems have to bypass a number of barriers especially crossing the cell membrane and nuclear envelope. Here we report a nucleolar targeting peptide (NrTP6) modified polymeric conjugate platform based on N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers for enhanced nuclear d...
Source
#1Yucheng Xiang (Sichuan University)H-Index: 1
#2Liqiang Chen (Sichuan University)
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 4 authors...
Complete tumor eradication is the ultimate goal of cancer therapy. However, the majority of anticancer drugs cause nonimmunogenic cell death and only exert on-site anticancer activities. The intrinsic genomic instability of cancer allows for the persistence and later expansion of treatment-resistant clones after surviving a sort of Darwinian selection of chemotherapy. Additional incorporation of immunotherapy, which is robust and individualized could be game-changing. Herein, we report a combina...
Source
#1Yucheng Xiang (Sichuan University)H-Index: 1
#2Liqiang Chen (Sichuan University)
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 4 authors...
Abstract Tumor cell nucleus is the ultimate target of many first-line chemotherapeutics and therapeutic genes. However, nuclear drug delivery is always hampered by multiple intracellular obstacles especially low efficiency of cellular uptake and insufficient nuclear trafficking. It is urgent to establish novel nuclear drug delivery systems to simultaneously overcome barriers including cell membranes and nuclear envelope. Herein, an N-(2-hydroxypropyl) methacrylamide (HPMA) polymer-based drug del...
Source
#1Yuanyuan Liu (Sichuan University)H-Index: 7
#2Zhou Zhou (Sichuan University)H-Index: 12
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 7 authors...
As a major clinical tumor chemotherapeutic burden, multidrug resistance (MDR) is often a result of up-regulation of P-glycoprotein (P-gp), which strongly enhances anticancer drug efflux. The excess mitochondrial reactive oxygen species (ROS) could not only inhibit the function of P-gp through insufficient adenosine triphosphate supply but also cause apoptosis in MDR cells. Here, we designed a mitochondria targeting nanoparticulate system (GNPs-P-Dox-GA) for overcoming MDR through enhanced ROS ge...
Source
#1Haohuan Li (Sichuan University)H-Index: 1
#2Pei Zhang (Sichuan University)H-Index: 1
Last. Tao Gong (Sichuan University)H-Index: 30
view all 8 authors...
Metastasis is a multistep biological process regulated by multiple signaling pathways. The integrity of the Golgi apparatus plays an important role in these signaling pathways. Inspired by the mechanism and our previous finding about accumulation of chondroitin sulfate in Golgi apparatus in hepatic stellate cells, we developed a Golgi apparatus-targeting prodrug nanoparticle system by synthesizing retinoic acid (RA)-conjugated chondroitin sulfate (CS) (CS–RA). The prodrug nanoparticles appeared ...
1 CitationsSource
#1Luyao Wang (Sichuan University)H-Index: 4
#2Bingjie Zhou (Sichuan University)H-Index: 1
Last. Ling Zhang (Sichuan University)H-Index: 4
view all 11 authors...
Currently, prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advanced prostate cancer. However, common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration, even with the help of conventional drug delivery systems. Here, encouraged by recent studies showing possible drug retention and tissue penetration advantages of unconventional non-spherical nanoparticle...
1 CitationsSource
#1Minglu ZhouH-Index: 1
#2Manling TangH-Index: 1
Last. Yuan HuangH-Index: 22
view all 5 authors...
Source
#1Minglu Zhou (Sichuan University)H-Index: 1
#2Lijia Li (Sichuan University)H-Index: 3
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 7 authors...
Abstract Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (HPMA) polymer–drug conjugates, we designed an effective system that combined drug-efflux circumvention and mitochondria targeting of anticancer drug doxorubicin (Dox). Briefly, Dox was modified with mitochondrial membrane penetrating pe...
1 CitationsSource
12345678910