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Geert Jan Biessels
Utrecht University
411Publications
51H-index
9,479Citations
Publications 415
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#1Liwen Zhang (NUS: National University of Singapore)H-Index: 1
#2Geert Jan BiesselsH-Index: 51
Last.Yng Miin Loke (NUS: National University of Singapore)H-Index: 4
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Cerebral microinfarcts (CMIs), a novel cerebrovascular marker, are prevalent in Alzheimer’s disease (AD) and associated with cognitive impairment. Nonetheless, the underlying mechanism of how CMIs ...
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#1Florin Despa (UK: University of Kentucky)H-Index: 8
#2Larry B. Goldstein (UK: University of Kentucky)H-Index: 83
Last.Geert Jan Biessels (UU: Utrecht University)H-Index: 51
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#1Jacob-Jan Sloots (UU: Utrecht University)
#2Geert Jan Biessels (UU: Utrecht University)H-Index: 51
Last.Jaco J.M. Zwanenburg (UU: Utrecht University)H-Index: 33
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Abstract Microvascular blood volume pulsations due to the cardiac and respiratory cycles induce brain tissue deformation and, as such, are considered to drive the brain's waste clearance system. We have developed a high-field magnetic resonance imaging (MRI) technique to quantify both cardiac and respiration-induced tissue deformations, which could not be assessed noninvasively before. The technique acquires motion encoded snapshot images in which various forms of motion and confounders are enta...
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#1Nick A. Weaver (UU: Utrecht University)H-Index: 4
#2Lei ZhaoH-Index: 4
Last.Geert Jan Biessels (UU: Utrecht University)H-Index: 51
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Abstract Introduction The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility ...
4 CitationsSource
#1Nick A. Weaver (UU: Utrecht University)H-Index: 4
#2Thomas Doeven (UU: Utrecht University)
Last.Geert Jan Biessels (UU: Utrecht University)H-Index: 51
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Abstract White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH locat...
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#1Emrah DüzelH-Index: 53
#2Julio Acosta-Cabronero (UCL: University College London)H-Index: 24
Last.Oliver SpeckH-Index: 46
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Abstract Introduction The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical r...
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Background Patients with type 2 diabetes have an increased risk of cognitive impairment which can lead to impaired diabetes self-management and an increased risk of diabetes-related complications. Routine screening for cognitive impairment in elderly patients with type 2 diabetes is therefore increasingly advocated. The aim of this study is to investigate whether people with type 2 diabetes and screen-detected cognitive impairment use acute health care services more often than patients not suspe...
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#1Kim Blom (UU: Utrecht University)H-Index: 3
#2Huiberdina L. Koek (UU: Utrecht University)H-Index: 18
Last.Pieter A. DoevendansH-Index: 83
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Abstract We estimated associations of subjective cognitive decline (SCD) with neuro-imaging markers of dementia and cognitive functioning in patients with a history of vascular disease without objective cognitive impairment. Within the SMART-Medea study, 599 patients (62±9 years) had 1.5T brain MRI and cognitive testing at baseline and after 8 years of follow-up. Using multiple regression analyses, we estimated cross-sectional and longitudinal associations of SCD according to research criteria w...
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#2Annebet E. LeeuwisH-Index: 5
Last.Wiesje M. van der FlierH-Index: 77
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Background and Purpose— Patients with cardiovascular disease are at increased risk for cognitive decline. We studied the occurrence and profile of cognitive impairment in 3 patient groups as exempl...
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#1Jurre H. Verwer (UU: Utrecht University)H-Index: 2
#2Yael D. Reijmer (UU: Utrecht University)H-Index: 27
Last.Geert Jan Biessels (UU: Utrecht University)H-Index: 51
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