Ravi K. Das
University College London
Publications 47
#1Grace Gale (UCL: University College London)H-Index: 2
#2V. Hennessy (UCL: University College London)
Last.Ravi K. Das (UCL: University College London)H-Index: 15
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Background: Alcohol use disorders can be conceptualised as a learned pattern of maladaptive alcohol-consumption behaviours. The memories encoding these behaviours centrally contribute to long-term excessive alcohol consumption and are a key therapeutic target. The transient period of memory instability sparked during memory reconsolidation offers a therapeutic window to directly rewrite these memories using targeted behavioural interventions. However, clinically-relevant demonstrations of the ef...
#1Daniel J. Paulus (UH: University of Houston)H-Index: 11
#2Sunjeev K. Kamboj (UCL: University College London)H-Index: 18
Last.Michael E. Saladin (MUSC: Medical University of South Carolina)H-Index: 36
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Memories are often conceptualized as permanent entities; however, retrieval of memories via stimulus prompts can return them to an active state, which initiates a period of lability before the memories are reconsolidated into long-term storage. Importantly, during this period, memories can be disrupted/altered. A growing body of work has focused on translating animal and experimental science into reconsolidation-based interventions for clinical disorders maintained by maladaptive memories. Inter...
#1Ravi K. Das (UCL: University College London)H-Index: 15
#2Grace Gale (UCL: University College London)H-Index: 2
Last.Sunjeev K. Kamboj (UCL: University College London)H-Index: 18
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Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRMs and prevent relapse. However, reliable means for pharmacologically weakening MRMs in humans remain elusive. Here we demonstrate that the N-methyl D-aspartate (NMDA) antagonist ketamine is able to disrupt M...
1 CitationsSource
#1H. Valerie Curran (UCL: University College London)H-Index: 4
#2Chandni Hindocha (UCL: University College London)H-Index: 13
Last.Tom P. Freeman (UCL: University College London)H-Index: 22
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BACKGROUND: Changes in cannabis regulation globally make it increasingly important to determine what predicts an individual's risk of experiencing adverse drug effects. Relevant studies have used diverse self-report measures of cannabis use, and few include multiple biological measures. Here we aimed to determine which biological and self-report measures of cannabis use predict cannabis dependency and acute psychotic-like symptoms. METHOD: In a naturalistic study, 410 young cannabis users were a...
7 CitationsSource
#1H. Valerie CurranH-Index: 43
#2Chandni HindochaH-Index: 13
Last.Tom P. FreemanH-Index: 22
view all 6 authors...
#2Ravi K. Das (UCL: University College London)H-Index: 15
1 CitationsSource
#1Valerie CurranH-Index: 8
#2Claire MokryszH-Index: 10
Last.Cja MorganH-Index: 36
view all 7 authors...
#1Ravi K. DasH-Index: 15
#2Grace GaleH-Index: 2
Last.Sunjeev K. KambojH-Index: 3
view all 11 authors...
#1Chandni Hindocha (UCL: University College London)H-Index: 13
#2Tom P. Freeman (UCL: University College London)H-Index: 22
Last.Hv Curran (UCL: University College London)H-Index: 24
view all 10 authors...
Acute nicotine abstinence in cigarette smokers results in deficits in performance on specific cognitive processes, including working memory and impulsivity which are important in relapse. Cannabidiol (CBD), the non-intoxicating cannabinoid found in cannabis, has shown pro-cognitive effects and preliminary evidence has indicated it can reduce the number of cigarettes smoked in dependent smokers. However, the effects of CBD on cognition have never been tested during acute nicotine withdrawal. The ...
6 CitationsSource