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Anshu Bhardwaj
Council of Scientific and Industrial Research
40Publications
10H-index
242Citations
Publications 41
Newest
#1Vipin Singh (Chandigarh University)H-Index: 1
#2Bani Jolly (CSIR: Council of Scientific and Industrial Research)H-Index: 1
Last.Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
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Abstract The human mitochondrion is a unique semi-autonomous organelle with a genome of its own and also requires nuclear encoded components to carry out its functions. In addition to being the powerhouse of the cell, mitochondria plays a central role in several metabolic pathways. It is therefore challenging to delineate the cause-effect relationship in context of mitochondrial dysfunction. Several studies implicate mutations in mitochondrial DNA (mtDNA) in various complex diseases. The human m...
1 CitationsSource
#1Anurag Passi (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Bani Jolly (CSIR: Council of Scientific and Industrial Research)H-Index: 1
Last.Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
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Abstract Antimicrobial resistance (AMR) is the outcome of genotypic and phenotypic diversification of lineages that is rapidly increasing among various pathogenic strains globally. In 2017 the World Health Organization (WHO) released a list of priority pathogens that can only be tackled with the discovery of novel antibiotics. New drug discovery and development entails high costs and attrition rates and therefore new strategies to address AMR are urgently needed. With the accumulation of large v...
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Behavioral Finance explains the sociological and psychological factors that have an impact on the selection making behaviors of individual and recently affect the financial market. Various researchers classified various biases into various types. This paper provides a comprehensive review on behavioral biases and grouping of various variables into one main variable. This study takes into consideration the existing work, controversies and conclusion that are properly brought about to make the ong...
#1Anurag Passi (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Neeraj Kumar Rajput (CSIR: Council of Scientific and Industrial Research)H-Index: 3
Last.Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
view all 4 authors...
Tuberculosis (TB) is the world’s leading infectious killer with 1.8 million deaths in 2015 as reported by WHO. It is therefore imperative that alternate routes of identification of novel anti-TB compounds are explored given the time and costs involved in new drug discovery process. Towards this, we have developed RepTB. This is a unique drug repurposing approach for TB that uses molecular function correlations among known drug-target pairs to predict novel drug-target interactions. In this study...
3 CitationsSource
#1Anamika Singh Gaur (Indian Institute of Chemical Technology)H-Index: 2
#2Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
Last.G. Narahari Sastry (Indian Institute of Chemical Technology)H-Index: 38
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5 CitationsSource
#1Iti Saraav (Miranda House, University of Delhi)H-Index: 3
#2Kirti Pandey (Miranda House, University of Delhi)H-Index: 3
Last.Sadhna Sharma (Miranda House, University of Delhi)H-Index: 5
view all 7 authors...
Abstract Limited efficacy of Bacillus Calmette–Guerin vaccine has raised the need to explore other immunogenic candidates to develop an effective vaccine against Mycobacterium tuberculosis (Mtb). Both CD4 + and CD8 + T cells play a critical role in host immunity to Mtb. Infection of macrophages with Mtb results in upregulation of mymA operon genes thereby suggesting their importance as immune targets. In the present study, after exclusion of self-peptides mymA operon proteins of Mtb were analyze...
3 CitationsSource
#1Arun SharmaH-Index: 10
#2Pooja GuptaH-Index: 4
Last.Anshu BhardwajH-Index: 10
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Increasingly, biofilms are being recognised for their causative role in persistent infections (like cystic fibrosis, otitis media, diabetic foot ulcers) and nosocomial diseases (biofilm-infected vascular catheters, implants and prosthetics). Given the clinical relevance of biofilms and their recalcitrance to conventional antibiotics, it is imperative that alternative therapeutics are proactively sought. We have developed dPABBs, a web server that facilitates the prediction and design of anti-bio...
10 CitationsSource
#1Kirti Pandey (Miranda House, University of Delhi)H-Index: 3
#2Monika Sharma (Miranda House, University of Delhi)H-Index: 7
Last.Sadhna Sharma (Miranda House, University of Delhi)H-Index: 5
view all 7 authors...
Abstract Objective/background There is an urgent need for a more effective vaccine against Mycobacterium tuberculosis (Mtb). Although CD4+ T cells play a central role in host immunity to Mtb, recent evidence suggests a critical role of CD8+ T cells in combating Mtb. In the present study, we have predicted HLA antigen class I binding peptides of DosR operon using an in-silico approach . This method is useful as an initial computational filtration of probable epitopes based on their binding abilit...
7 CitationsSource
#1V. Singh (Amity University)H-Index: 1
#2P. Gupta (CSIR: Council of Scientific and Industrial Research)H-Index: 1
Last.Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
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Mitochondria generate almost all of the energy needed by the cells to grow and sustain life and hence mitochondrial dysfunction may lead to severe disease phenotypes. The dysfunction may arise because of mutations in mitochondrial DNA (mtDNA), nuclear DNA (nDNA), or both, and manifest in a broad spectrum of disease phenotypes depending on the mutation load. The prevalence of mitochondrial diseases is 1 in 5000. Therefore evidence-based clinical practice protocols are proposed for mitochondrial d...
1 CitationsSource
#1E. Abinaya (SASTRA: Shanmugha Arts, Science, Technology & Research Academy)H-Index: 1
#2Pankaj Narang (JNU: Jawaharlal Nehru University)H-Index: 2
Last.Anshu Bhardwaj (CSIR: Council of Scientific and Industrial Research)H-Index: 10
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Genetic variations play a crucial role in differential phenotypic outcomes. Given the complexity in establishing this correlation and the enormous data available today, it is imperative to design machine-readable, efficient methods to store, label, search and analyze this data. A semantic approach, FROG: “FingeRprinting Ontology of Genomic variations” is implemented to label variation data, based on its location, function and interactions. FROG has six levels to describe the variation annotation...
2 CitationsSource
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