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André Y. Denault
Université de Montréal
SurgeryCardiologyCardiac surgeryAnesthesiaMedicine
321Publications
37H-index
4,323Citations
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Publications 326
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#1André Y. Denault (MHI: Montreal Heart Institute)H-Index: 37
#2Jennifer Palermo (UdeM: Université de Montréal)
Last. Stephan LangevinH-Index: 7
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#1William Beaubien-Souligny (UdeM: Université de Montréal)H-Index: 3
#2Paul-Eduard Neagoe (MHI: Montreal Heart Institute)H-Index: 9
Last. Martin G. Sirois (UdeM: Université de Montréal)H-Index: 27
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Abstract Background The intensity of inflammatory response triggered by cardiopulmonary bypass (CPB) during cardiac surgery has been associated with adverse outcomes. Neutrophils might contribute to organ injury through the liberation of DNA-histone based structures named neutrophil extracellular traps (NETs). Our objective was to assess circulating NETs levels before and after cardiac surgery in low-risk and high-risk patients. Methods This prospective cohort study included two groups of patien...
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#1Anne Quynh-Nhu Nguyen (UdeM: Université de Montréal)
#2André Y. Denault (MHI: Montreal Heart Institute)H-Index: 37
Last. Louis P. Perrault (MHI: Montreal Heart Institute)H-Index: 39
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Inhaled milrinone administered before cardiopulmonary bypass (CPB) reduces the severity of pulmonary hypertension during cardiac surgery. However, milrinone pharmacokinetics has not been determined for this route of administration. The objective of this study was to investigate inhaled milrinone dosing in vitro and early plasma concentrations in vivo after jet and mesh nebulization. Twelve pulmonary hypertensive patients scheduled for cardiac surgery were randomized to receive milrinone (5 mg) b...
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#1Connor O'Brien (Stanford University)H-Index: 6
#2William Beaubien-Souligny (MHI: Montreal Heart Institute)H-Index: 3
Last. Francois Haddad (Stanford University)H-Index: 31
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ABSTRACT Cardiogenic shock is classically defined by systemic hypotension with evidence of hypoperfusion and end-organ dysfunction. In modern practice, however, these metrics often incompletely describe cardiogenic shock (CS) as patients present with more advanced cardiovascular disease and greater degrees of multiorgan dysfunction. Understanding how perfusion, congestion, and end-organ dysfunction contribute to hypoxia at the cellular level are central to the diagnosis and management of CS. Alt...
1 CitationsSource
#1Lars Grønlykke (Copenhagen University Hospital)H-Index: 4
#2Etienne J. Couture (MHI: Montreal Heart Institute)H-Index: 2
Last. André Y. Denault (MHI: Montreal Heart Institute)H-Index: 37
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Abstract Objectives Right ventricular (RV) dysfunction in cardiac surgery is associated with increased mortality, morbidity and difficult separation from cardiopulmonary bypass (DSB). The primary objective of this study was to describe the prevalence and characteristics of patients with abnormal RV diastolic pressure gradient (PG). Our secondary objective was to explore the association between abnormal diastolic PG and DSB, post-operative complications, high central venous pressure (CVP) and hig...
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#1David CantyH-Index: 9
#2Kavi Mufti (Monash University)
Last. André Y. Denault (UdeM: Université de Montréal)H-Index: 37
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#1Alexis CournoyerH-Index: 5
#2Sylvie Cossette (UdeM: Université de Montréal)H-Index: 14
Last. André Y. Denault (UdeM: Université de Montréal)H-Index: 37
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Objective This study aimed to evaluate the association between the quantity of subcutaneous fat (assessed by skinfold thickness) and the inter-device agreement of 2 tissue oximeters. Design This is a prospective cohort study. Setting This study was conducted in a tertiary care academic urban hospital. Participants Healthy volunteers were recruited. Interventions All patients recruited had their tissue saturations and skinfold thickness measured at 4 different sites (shoulder, forearm, knee, and ...
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#1Evan Roter (McGill University)H-Index: 1
#2André Y. Denault (MHI: Montreal Heart Institute)H-Index: 37
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#1William Beaubien-Souligny (UdeM: Université de Montréal)H-Index: 3
#2André Y. Denault (UdeM: Université de Montréal)H-Index: 37
Last. Georges Desjardins (MHI: Montreal Heart Institute)H-Index: 6
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The approach to the patient with acute kidney injury (AKI) after cardiac surgery involves multiple aspects. These include the rapid recognition of reversible causes, the accurate identification of patients who will progress to severe stages of AKI, and the subsequent management of complications resulting from severe renal dysfunction. Unfortunately, the inherent limitations of physical examination and laboratory parameter results are often responsible for suboptimal clinical management. In this ...
1 CitationsSource
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