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Nina Cedergreen
University of Copenhagen
PesticideChemistryToxicityToxicologyBiology
114Publications
32H-index
3,294Citations
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Publications 119
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Pyrethroid insecticides are known to be highly toxic to most aquatic non-target organisms, but little is known about the mechanisms causing some species to be highly sensitivity while others are hardly affected by the pyrethroids. The aim of the present study was to measure the sensitivity (EC50-values) of ten aquatic invertebrates towards a 24 hour pulse of the pyrethroid cypermethrin, and subsequently test if the difference in sensitivity could be explained by measured morphological and physio...
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#1Yi Cao (UCPH: University of Copenhagen)H-Index: 1
#2Laia Herrero-Nogareda (UCPH: University of Copenhagen)
Last. Nina Cedergreen (UCPH: University of Copenhagen)H-Index: 32
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Abstract Acetylcholinesterase (AChE) and general-esterase (GE) activities are important to understand detoxification processes of xenobiotics. The assays to quantify them have employed different substrates, inhibitors, types of experiments (in vitro and in vivo) and model organisms. The aim of this work was to give a systematic overview of the effect of the above factors on the outcome of AChE and GE activity measurements. We showed that AChE activity could be measured with the substrate acetylt...
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#1Suraj DhakalH-Index: 2
#2Nicolai VittH-Index: 19
Last. Brian L. FredensborgH-Index: 17
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#1Kathrine Eggers Pedersen (UCPH: University of Copenhagen)H-Index: 3
#2Nanna Natacha Pedersen (UCPH: University of Copenhagen)
Last. Nina Cedergreen (UCPH: University of Copenhagen)H-Index: 32
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Abstract It is widely accepted that sensitivity towards pesticides varies significantly between species. Much less is known about the potential differences in pesticide sensitivity and its biological mechanism throughout the lifecycle of a single species. In the present study we used three life-stages (larvae, pupae and adult) of the holometabolous insect Tenebrio molitor to investigate: i) Life-stage specific differences in sensitivity towards the pyrethroid insecticide α-cypermethrin after top...
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In April 2017, the Organic Business Development Team released a report with 25 recommendations for the Minister of Environment and Food (Det okologiske erhvervsteam 2017). Among these was a recommendation that organic farmers should have opportunities for utilizing nutrients from treated domestic wastewater for nutrient recycling. A prerequisite for future use of nutrients from treated wastewater is, that quality requirements are met and that application can be explained to (and accepted by) con...
#1Xiaogang Jiang (UCPH: University of Copenhagen)H-Index: 2
#2Bjarne W. Strobel (UCPH: University of Copenhagen)H-Index: 22
Last. Hans Chr. Bruun Hansen (UCPH: University of Copenhagen)H-Index: 7
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Saponins form a group of plant-produced glycosides with potential as biopesticide ingredients. The environmental fate of saponins has never been fully investigated. In the present study, we use QS-18, a specific saponin from Quillaja saponaria as an example, to quantify hydrolysis under different conditions of pH, temperature and water chemical composition. Saponin hydrolysis in buffer solutions was base-catalyzed and followed first-order kinetics. Thus, hydrolysis was slow at pH 5.1 with a half...
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#1Janna Kuhlmann (UCPH: University of Copenhagen)
#2Andreas Kretschmann (UCPH: University of Copenhagen)H-Index: 14
Last. Nina Cedergreen (UCPH: University of Copenhagen)H-Index: 32
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Abstract The fungicide imazalil is a chiral compound with one R- and one S-enantiomer. Enantiomers, while having the same chemical properties, can differ in their biological activity expressed as efficacy/toxicity as well as in their degradation kinetics and pathways. Azoles such as imazalil have been shown to synergize the effect of pyrethroid insecticides like α-cypermethrin through inhibition of cytochrome P450 monooxygenase responsible for pyrethroid detoxification. The aim of this study was...
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#1Kathrine Eggers Pedersen (UCPH: University of Copenhagen)H-Index: 3
#2Brian L. Fredensborg (UCPH: University of Copenhagen)H-Index: 17
Last. Nina Cedergreen (UCPH: University of Copenhagen)H-Index: 32
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#2Simon J. MoreH-Index: 33
#3Vasileios BampidisH-Index: 14
Last. Christer HogstrandH-Index: 46
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This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk ...
14 CitationsSource
#1Michele Gottardi (UCPH: University of Copenhagen)H-Index: 6
#2Nina Cedergreen (UCPH: University of Copenhagen)H-Index: 32
Abstract The ability of azole fungicides to inhibit cytochrome P450 dependent metabolism is proposed to be the main mechanism for their synergizing effect on pyrethroid insecticide toxicity in aquatic invertebrates. This study investigates the correlation between inhibition strength and synergistic potential of azole fungicides in the crustacean Daphnia magna and the insect larvae Chironomus riparius. Inhibition strength was measured in vivo toward the cytochrome P450 catalysed conversion of 7-e...
1 CitationsSource
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