Tracey McLaughlin
Stanford University
Publications 108
#1Nadine Nagy (Stanford University)H-Index: 10
#2Vivekananda G. Sunkari (Stanford University)H-Index: 3
Last.Paul L. Bollyky (Stanford University)H-Index: 22
view all 11 authors...
Abstract Hyaluronan (HA), an extracellular matrix glycosaminoglycan, is implicated in the pathogenesis of both type 1 diabetes (T1D) as well as type 2 diabetes (T2D) and has been postulated to be increased in these diseases due to hyperglycemia. We have examined the serum and tissue distribution of HA in human subjects with T1D and T2D and in mouse models of these diseases and evaluated the relationship between HA levels and glycemic control. We found that serum HA levels are increased in T2D bu...
#1Christopher M. Mulla (Harvard University)H-Index: 4
#2Allison B. Goldfine (Harvard University)H-Index: 39
Last.Mary-Elizabeth Patti (Harvard University)H-Index: 52
view all 13 authors...
Background Hypoglycemia is an increasingly recognized complication of bariatric surgery. Mechanisms contributing to glucose lowering remain incompletely understood. We aimed to identify differentially abundant plasma proteins in patients with post-bariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB), compared to asymptomatic post-RYGB.
1 CitationsSource
#1Candice Allister-Price (UC Davis: University of California, Davis)H-Index: 1
#2Colleen M. Craig (Stanford University)H-Index: 6
Last.Tracey McLaughlin (Stanford University)H-Index: 41
view all 5 authors...
African-American women have the greatest prevalence of obesity in the United States, and higher rates of type 2 diabetes than Caucasian women, yet paradoxically lower plasma triglycerides (TG), visceral fat and intrahepatic fat, and higher high-density lipoprotein (HDL)-cholesterol. Visceral fat has not been evaluated against insulin resistance in African-American women, and TG/HDL-cholesterol has been criticized as a poor biomarker for insulin resistance in mixed-sex African-American population...
1 CitationsSource
#1Gireesh K. BoguH-Index: 11
#2Michael SnyderH-Index: 139
Last.Tracey McLaughlinH-Index: 41
view all 3 authors...
#1Tracey McLaughlin (Stanford University)H-Index: 41
#2Elizabeth J. Zanley (Stanford University)
Last.Edgar G. Engleman (Stanford University)H-Index: 80
view all 9 authors...
Background/Methods: Visceral adipose tissue (VAT) is associated with increased risk for T2D and CVD. This depot, which accounts for only 5-10% of total fat mass, may play a relatively important role in determining insulin resistance (IR) due to its proximity to gut lymphatics and liver. Immune cells in fat respond to adipocyte stress and bacterial antigens from the gut with cytokine release, adversely affecting hepatic and systemic glucose metabolism. Few human studies have examined inflammation...
#1Sophia Miryam (Stanford University)H-Index: 8
#2Kévin Contrepois (Stanford University)H-Index: 11
Last.Michael Snyder (Cardiovascular Institute of the South)H-Index: 139
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Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring enable deep molecular and physiological profiling and may provide important tools for precision health. We explored the ability of deep longitudinal profiling to make health-related discoveries, identify clinically relevant molecular pathways and affect behavior in a prospective...
15 CitationsSource
#1Wenyu Zhou (Stanford University)H-Index: 11
#2M. Reza Sailani (Stanford University)H-Index: 10
Last.Michael Snyder (Stanford University)H-Index: 139
view all 49 authors...
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set...
10 CitationsSource
#1Tracey McLaughlin (Stanford University)H-Index: 41
#2Fahim Abbasi (Stanford University)H-Index: 47
Last.Samuel W. Cushman (NIH: National Institutes of Health)H-Index: 57
view all 6 authors...
Abstract Background and Aims Overweight and obesity increase risk for diabetes and cardiovascular disease, largely through development of insulin resistance. Benefits of dietary weight loss are documented for obese individuals with insulin resistance. Similar benefits have not been shown in overweight individuals. We sought to quantify whether dietary weight loss improves metabolic risk profile in overweight insulin-resistant individuals, and evaluated potential mediators between weight loss and...
#1Shannon Rego (Stanford University)H-Index: 6
#2Orit Dagan-Rosenfeld (Stanford University)H-Index: 3
Last.Michael Snyder (Stanford University)H-Index: 139
view all 16 authors...
2 CitationsSource
#1Marzieh Salehi (University of Texas at Austin)H-Index: 16
#2Adrian Vella (Mayo Clinic)H-Index: 42
Last.Mary-Elizabeth Patti (Harvard University)H-Index: 52
view all 4 authors...
17 CitationsSource