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Sachin Kumar Singh
Lovely Professional University
ChemistryChromatographyMedicineDissolutionPharmacology
79Publications
10H-index
293Citations
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Publications 107
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Diabetic wound (DW) is considered as one of the serious complications associated with diabetes mellitus. Though some pharmacological approaches are available for managing DW, none of them has been reported to be very effective. Widely accepted options for its management include treatment of infection caused by various pathogens, wound debridement, reducing the period of the prolonged inflammatory phase, and supervision of the remodeling phase of wound healing. Satisfactory management of DW thus ...
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#1Bhupinder Kapoor (LPU: Lovely Professional University)H-Index: 4
#2Reena Gupta (LPU: Lovely Professional University)H-Index: 2
Last. Rajan Kumar (LPU: Lovely Professional University)H-Index: 1
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The objective of the current investigation was to develop a simple, rapid, and stability-indicating high-performance liquid chromatography method and to study the degradation behavior of sulfapyridine (SP) under different International Conference on Harmonization (ICH)-recommended conditions. The chromatographic method was developed using C18 (250 x 4.6 mm, 5 mu) column, and mobile phase consisting of acetonitrile-0.1% formic acid (30:70 v/v) at ambient temperature, at a flow rate of 1 mL/min. T...
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#1Rajan KumarH-Index: 1
#2Rakesh KumarH-Index: 93
Last. Manish VyasH-Index: 2
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#1Dipanjoy Ghosh (LPU: Lovely Professional University)H-Index: 1
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 10
Last. Ankit Awasthi (LPU: Lovely Professional University)H-Index: 1
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AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of ...
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#1Meenu Mehta (Centenary Institute)H-Index: 1
#1Meenu Mehta (Centenary Institute)
Last. Dinesh Kumar ChellappanH-Index: 9
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Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases involve multiple pulmonary components, including airways and lungs that lead to their abnormal physiological functioning. Several signaling pathways have been reported to play an important role in the pathophysiology of respiratory diseases. These pathways, in addition, become the compounding factors contributing to the clini...
1 CitationsSource
#1Dinesh Kumar Chellappan (International Medical University)H-Index: 8
#1Dinesh Kumar Chellappan (International Medical University)H-Index: 9
Last. Meenu MehtaH-Index: 4
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Neutrophils are essential effector cells of immune system for clearing the extracellular pathogens during inflammation and immune reactions. Neutrophils play a major role in chronic respiratory diseases. In respiratory diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, lung cancer and others, there occurs extreme infiltration and activation of neutrophils followed by a cascade of events like oxidative stress and dysregulated cellular proteins that eventually result ...
3 CitationsSource
#1Yogita Kumari (LPU: Lovely Professional University)H-Index: 4
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 10
Last. Clarisse Ayinkamiye (LPU: Lovely Professional University)
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Abstract The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential −10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced rat model revealed that AuNPs conjugated insulin (AuNPs-INS) in high dose caused 3.36 folds d...
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