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Yih Horng Tan
University of Missouri–St. Louis
19Publications
11H-index
675Citations
Publications 19
Newest
#1Jay K. Bhattarai (UMSL: University of Missouri–St. Louis)H-Index: 4
#2Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 6 authors...
Abstract The interactions of the lectin Concanavalin A (Con A) with self-assembled monolayers (SAMs) of thiolated mono-, di-, and tri-mannosides were studied on the surface of gold wires using electrochemical impedance spectroscopy (EIS). The SAMs of mannosides were prepared either pure or along with thiolated triethylene glycol (TEG) at different molar ratios (1:1, 1:2, 1:4, 1:9, and 1:19) to better understand and optimize the interaction conditions. The charge-transfer resistance of the [Fe(CN...
#1Allan J. Alla (UMSL: University of Missouri–St. Louis)H-Index: 4
#2Felipe B. d’ Andrea (UMSL: University of Missouri–St. Louis)H-Index: 1
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 7 authors...
Abstract The surface of nanoporous gold (np-Au) monoliths was modified via a flow method with the lectin Concanavalin A (Con A) to develop a substrate for separation and extraction of glycoproteins. Self-assembled monolayers (SAMs) of α-lipoic acid (LA) on the np-Au monoliths were prepared followed by activation of the terminal carboxyl groups to create amine reactive esters that were utilized in the immobilization of Con A. Thermogravimetric analysis (TGA) was used to determine the surface cove...
#1Binod Pandey (UMSL: University of Missouri–St. Louis)H-Index: 7
#2Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 6 authors...
#1Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
#2Shana E. Terrill (UMSL: University of Missouri–St. Louis)H-Index: 3
Last.Michael R. Nichols (UMSL: University of Missouri–St. Louis)H-Index: 9
view all 5 authors...
Microglial cells play a critical role in the propagation of neuroinflammation in the central nervous system. Microglia sense and respond to environmental signals including chemical, physical and biological cues from the surrounding cell/tissue components. In this project, our goal was to examine the effects of surface texture on BV-2 microglia morphology and function by comparing flat and nanoporous gold (np-Au) surfaces to the more conventional glass. The biocompatibility of np-Au with microgli...
Comparative study of Surface-Tethered Iterative Carbohydrate Synthesis (STICS) using HPLC-assisted experimental setup clearly demonstrates benefits of using longer spacer-anchoring systems. The use of mixed self-assembled monolayers helps provide the required space for glycosylation reaction around the immobilized glycosyl acceptor. Both extension of the spacer length and using mixed self-assembled monolayers help promote the reaction, and the beneficial effects may include moving the glycosyl a...
#1Binod Pandey (UMSL: University of Missouri–St. Louis)H-Index: 7
#2Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 6 authors...
Abstract Self-assembled monolayers (SAMs) of α- d -Gal-(1→4)-β- d -Gal-(1→4)-β- d -Glc-mercaptooctane (globotriose, Gb3-C 8 -SH) were prepared both as single-component SAMs and as mixed SAMs with either octanethiol (OCT) or 8-mercapto-3,6-dioxaoctanol (HO-PEG 2 -SH), on flat gold and on nanoporous gold (NPG) electrodes. The binding of soybean agglutinin (SBA) to the globotriose (Gb3) unit in the SAMs was then studied using electrochemical impedance spectroscopy (EIS), which is a label free metho...
#1Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
#2Kohki Fujikawa (UMSL: University of Missouri–St. Louis)H-Index: 11
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 7 authors...
Monoliths of nanoporous gold (np-Au) were modified with self-assembled monolayers of octadecanethiol (C18-SH), 8-mercaptooctyl α-D-mannopyranoside (αMan-C8-SH), and 8-mercapto-3,6-dioxaoctanol (HO-PEG2-SH), and the loading was assessed using thermogravimetric analysis (TGA). Modification with mixed SAMs containing αMan-C8-SH (at a 0.20 mole fraction in the SAM forming solution) with either octanethiol or HO-PEG2-SH was also investigated. The np-Au monoliths modified with αMan-C8-SH bind the lect...
#1N. Vijaya GaneshH-Index: 5
#2Kohki FujikawaH-Index: 11
Last.Alexei V. DemchenkoH-Index: 34
view all 5 authors...
A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup.
#1Binod Pandey (UMSL: University of Missouri–St. Louis)H-Index: 7
#2Yih Horng Tan (UMSL: University of Missouri–St. Louis)H-Index: 11
Last.Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
view all 5 authors...
We have prepared SAMs containing 8-mercaptooctyl α-D-mannopyranoside either as a single component or in mixed SAMs with n-octanethiol on flat gold surfaces and on nanoporous gold. Electrochemical impedance spectroscopy showed that the mixed SAMs on flat gold surfaces showed the highest Con A binding, near 1:9 solution molar ratio of thiolated α-mannoside to n-octanethiol, whereas those on NPG showed the highest response at 1:19 solution molar ratio of thiolated α-mannoside to n-octanethiol. Atom...
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