Match!
Cecil Chern-Chyi Yen
National Institutes of Health
22Publications
11H-index
403Citations
Publications 22
Newest
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 2
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 6 authors...
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsol...
#1Emily C. Leibovitch (NIH: National Institutes of Health)H-Index: 10
#2Breanna Caruso (NIH: National Institutes of Health)H-Index: 6
Last.Steven Jacobson (NIH: National Institutes of Health)H-Index: 55
view all 13 authors...
Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and HHV-6B accelerate an MS-like neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE). Altho...
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 2
#2Frank Q. Ye (NIH: National Institutes of Health)H-Index: 33
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 7 authors...
Abstract The common marmoset (Callithrix jacchus) is a New-World monkey of growing interest in neuroscience. Magnetic resonance imaging (MRI) is an essential tool to unveil the anatomical and functional organization of the marmoset brain. To facilitate identification of regions of interest, it is desirable to register MR images to an atlas of the brain. However, currently available atlases of the marmoset brain are mainly based on 2D histological data, which are difficult to apply to 3D imaging ...
#1Sang-Ho ChoiH-Index: 11
#2Allison L. AraiH-Index: 1
Last.Afonso C. SilvaH-Index: 35
view all 7 authors...
Background and Purpose— MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins—substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia. Methods— SHR (spontaneously hypertensive rats) and normotensi...
#1Yoshiyuki Hirano (NIH: National Institutes of Health)H-Index: 16
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 8 authors...
#1Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
#2Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 3 authors...
Abstract Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) has become a major tool to map neural activity. However, the spatiotemporal characteristics of the BOLD functional hemodynamic response across the cortical layers remain poorly understood. While human fMRI studies suffer from low spatiotemporal resolution, the use of anesthesia in animal models introduces confounding factors. Additionally, inflow contributions to the fMRI signal become non-negligible w...
#1Camille R. Toarmino (UCSD: University of California, San Diego)H-Index: 2
Last.Afonso C. SilvaH-Index: 35
view all 7 authors...
Abstract The primate auditory cortex is organized into a network of anatomically and functionally distinct processing fields. Because of its tonotopic properties, the auditory core has been the main target of neurophysiological studies ranging from sensory encoding to perceptual decision-making. By comparison, the auditory belt has been less extensively studied, in part due to the fact that neurons in the belt areas prefer more complex stimuli and integrate over a wider frequency range than neur...
#1Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 6 authors...
Purpose The common marmoset (Callithrix jacchus) is a New World primate of increasing interest to neuroscience and in translational brain research. The present work describes the design and implementation of individualized 8-channel receive-only radiofrequency (RF) coil arrays that provide whole-brain coverage and allow anatomical and functional MRI experiments in conscious, awake marmosets. Methods The coil arrays were designed with their elements embedded inside individualized restraint helmet...
#1Annabelle M. Belcher (UMB: University of Maryland, Baltimore)H-Index: 11
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Dardo Tomasi (NIH: National Institutes of Health)H-Index: 53
view all 9 authors...
In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or “hubs”, and we have recently proposed local functional connectivity density (lFCD) mapping to identify highly-connected nodes in the human brain. Here we imaged awake nonhuman primates to test whether, like the h...
123