Alexander G. Heriot
Peter MacCallum Cancer Centre
CancerSurgeryColorectal cancerGeneral surgeryMedicine
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Publications 264
#1Olivia C. Smibert (Peter MacCallum Cancer Centre)H-Index: 5
#2Monica A. Slavin (Peter MacCallum Cancer Centre)H-Index: 40
Last. Leon J. Worth (Peter MacCallum Cancer Centre)H-Index: 26
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Background CRS-HIPEC is associated with improved cancer survival but an increased risk of infection.
1 CitationsSource
#1Shane Belvedere (Royal Melbourne Hospital)
#2Jake D. Foster (Peter MacCallum Cancer Centre)
Last. Alexander G. Heriot (Peter MacCallum Cancer Centre)H-Index: 40
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#1Vignesh Narasimhan (Peter MacCallum Cancer Centre)H-Index: 2
Last. Gayle Xy Tye (University of Adelaide)
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Purpose: Colorectal cancer (CRC) patients with peritoneal metastases (CRPM) have limited treatment options and the lowest CRC survival rates. We aimed to determine whether organoid testing could help guide precision treatment for CRPM patients, as the clinical utility of prospective, functional drug screening including non-standard agents is unknown. Experimental Design: CRPM organoids (peritonoids) isolated from patients underwent parallel next-generation sequencing and medium-throughput drug p...
#1S. K. WarrierH-Index: 3
#2Stephen BellH-Index: 8
Last. Alexander G. HeriotH-Index: 40
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#1Peadar S. Waters (Peter MacCallum Cancer Centre)H-Index: 1
#2Francis Cheung (Peter MacCallum Cancer Centre)H-Index: 1
Last. Andrew R. L. StevensonH-Index: 18
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INTRODUCTION: Robotic transanal minimally invasive surgery (R-TAMIS) is gaining traction around the globe as an alternative to laparoscopic conventional TAMIS (L-TAMIS) for local excision of benign and early malignant rectal lesions. AIMS: To analyse patient and oncological outcomes of R-TAMIS in a single centre of consecutive cases. METHODS: A prospective analysis of consecutive R-TAMIS procedures over a 12-month period was performed. Data was collated from hospital databases and theatre regist...
#1Peadar S. Waters (Peter MacCallum Cancer Centre)H-Index: 1
#2Satish K. Warrier (Peter MacCallum Cancer Centre)H-Index: 9
Last. Alexander G. Heriot (University of Melbourne)H-Index: 40
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#1Vignesh Narasimhan (University of Melbourne)H-Index: 2
#2Geraldine Ooi (Alfred Hospital)H-Index: 1
Last. Alexander G. Heriot (University of Melbourne)H-Index: 40
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Peritoneal metastases confer the worst survival among all sites in patients with metastatic colorectal cancer. They develop largely through transcoelomic spread, with a sequence of events that allow cells to first detach from primary tumours, survive in the peritoneal environment, attach to the peritoneal surface of organs and migrate into the submesothelial space to create a microenvironment conducive to metastatic growth. Diagnostic challenges have previously hindered early identification of p...
#1Jordan M. Hamilton (Peter MacCallum Cancer Centre)
#2Hussain Al Khdhur (Peter MacCallum Cancer Centre)
Last. Alexander G. Heriot (Peter MacCallum Cancer Centre)H-Index: 40
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#1Yan QinH-Index: 1
#2Carolyn ShembreyH-Index: 2
Last. Frédéric HollandeH-Index: 28
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Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, laminin 521 (LN521), sustains embryonic and induced pluripotent stem cell self-renewal, but its putative role in cancer is poorly described. In the present study we found that LN521 promotes colorectal cancer (CRC) cell self-renewal and invasion. siRNA-mediated knockdown of endogenously-produced laminin alpha 5, as well as treatment with neutralizing antibodies against i...