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Mark A. Atkinson
University of Florida
Publications 502
Published on Jan 9, 2019in Frontiers in Endocrinology 3.52
Abu Saleh Md Moin6
Estimated H-index: 6
Chiara Montemurro2
Estimated H-index: 2
+ 9 AuthorsRobert A. Rizza80
Estimated H-index: 80
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Published on Mar 1, 2019in Diabetes Research and Clinical Practice 2.55
Asher Fawwad10
Estimated H-index: 10
(Baqai Medical University),
Denira Govender (University of Sydney)+ 7 AuthorsJanelle A. Noble30
Estimated H-index: 30
(Children's Hospital Oakland Research Institute)
Abstract Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. One hundred subjects aged HLA-DRB1 using high-resolution genotyping technology. Ninety-nine subjects were clinically diagnosed as type 1 diabetes (T1D)...
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Published on Jan 23, 2019in Diabetologia 6.02
Jessica L. Dunne5
Estimated H-index: 5
Sarah J. Richardson23
Estimated H-index: 23
(University of Exeter)
+ 9 AuthorsRichard E. Lloyd37
Estimated H-index: 37
(Baylor College of Medicine)
In type 1 diabetes, pancreatic beta cells are destroyed by chronic autoimmune responses. The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infections have long been considered as candidates for environmental triggers but, given the lack of evidence for an acute, widespread, cytopathic effect in the pancreas in type 1 diabetes or for a closely related temporal association of diabetes onset with such infections, a role for ...
1 Citations Source Cite
Published on Mar 18, 2019in arXiv: Other Quantitative Biology
Estimated H-index: 132
(Stanford University),
Shin Lin14
Estimated H-index: 14
+ 22 AuthorsRahul Satija29
Estimated H-index: 29
Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) aims to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agen...
Published on Jan 1, 2019in The Lancet Diabetes & Endocrinology 19.31
Mark A. Atkinson82
Estimated H-index: 82
(University of Florida),
Bart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center)
+ 2 AuthorsMark Peakman51
Estimated H-index: 51
Summary With the conceptual advance about four decades ago that type 1 diabetes represents an autoimmune disease, hope arose that immune-based therapies would soon emerge to prevent and reverse the disorder. However, despite dozens of clinical trials seeking to achieve these goals, the promise remains unfulfilled, at least in a pragmatic form. With the benefit of hindsight, several important reasons are likely to account for this disappointing outcome, including failure to appreciate disease het...
1 Citations Source Cite
Published on Feb 1, 2019in Metabolomics 3.51
Allison L. O’Kell2
Estimated H-index: 2
(University of Florida),
Timothy J. Garrett19
Estimated H-index: 19
(University of Florida)
+ 1 AuthorsMark A. Atkinson82
Estimated H-index: 82
(University of Florida)
Introduction We recently identified variances in serum metabolomic profiles between fasted diabetic and healthy dogs, some having similarities to those identified in human type 1 diabetes.
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Published on Mar 1, 2019in Cell Metabolism 20.57
Yue J. Wang6
Estimated H-index: 6
(University of Pennsylvania),
Daniel Traum3
Estimated H-index: 3
(University of Pennsylvania)
+ 8 AuthorsKyong-Mi Chang25
Estimated H-index: 25
(University of Pennsylvania)
Summary The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Herein, we have developed a panel of 33 antibodies that allows for the quantification of key cell types including pancreatic exocrine cells, islet cells, immune cells, and stro...
2 Citations Source Cite
Published on Feb 1, 2019in Cell Metabolism 20.57
Peter J. Thompson (University of California, San Francisco), Ajit Shah2
Estimated H-index: 2
(University of California, San Francisco)
+ 3 AuthorsAnil Bhushan2
Estimated H-index: 2
(University of California, San Francisco)
Summary Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell destruction drives the disease, but whether beta cells actively participate in the pathogenesis remains unclear. Here, we show that during the natural history of T1D in humans and the non-obese diabetic (NOD) mouse model, a subset of beta cells acquires a senescence-associated secretory phenotype (SASP). Senescent beta ce...
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Published on Mar 15, 2019in Analytical Chemistry 6.04
Lian Yi1
Estimated H-index: 1
Chia-Feng Tsai + 13 AuthorsRichard D. Smith120
Estimated H-index: 120
Comprehensive phosphoproteomic analysis of small populations of cells remains a daunting task due primarily to the insufficient MS signal intensity from low concentrations of enriched phosphopeptides. Isobaric labeling has a unique multiplexing feature where the “total” peptide signal from all channels (or samples) triggers MS/MS fragmentation for peptide identification, while the reporter ions provide quantitative information. In light of this feature, we tested the concept of using a “boosting...
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Published on Mar 26, 2019in ACS Biomaterials Science & Engineering 4.43
Jamal S. Lewis9
Estimated H-index: 9
Joshua M. Stewart2
Estimated H-index: 2
+ 9 AuthorsMichael Clare-Salzler40
Estimated H-index: 40
Antigen specificity is a primary goal in developing curative therapies for autoimmune disease. Dendritic cells (DCs), as the most effective antigen presenting cells in the body, represent a key target to mediate restoration of antigen-specific immune regulation. Here, we describe an injectable, dual-sized microparticle (MP) approach that employs phagocytosable ~1 µm and non-phagocytosable ~30 µm MPs to deliver tolerance-promoting factors both intracellularly and extracellularly, as well as the t...
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