Archie Campbell
University of Edinburgh
Genome-wide association studyPopulationGeneticsLocus (genetics)Biology
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Publications 167
#1Samuel Rupprechter (Edin.: University of Edinburgh)H-Index: 1
#2Liana Romaniuk (Edin.: University of Edinburgh)H-Index: 16
Last. Mathew A. Harris (Edin.: University of Edinburgh)H-Index: 9
view all 19 authors...
Major depressive disorder is a leading cause of disability and significant mortality, yet mechanistic understanding remains limited. Over the past decade evidence has accumulated from case-control studies that depressive illness is associated with blunted reward activation in the basal ganglia and other regions such as the medial prefrontal cortex. However it is unclear whether this finding can be replicated in a large number of subjects. The functional anatomy of the medial prefrontal cortex an...
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 23
#2Yun Ju Sung (WashU: Washington University in St. Louis)H-Index: 18
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
#1Christoph B. Messner (Francis Crick Institute)H-Index: 3
#2Vadim Demichev (Francis Crick Institute)H-Index: 1
Last. Marco Kreidl (Francis Crick Institute)
view all 32 authors...
The COVID-19 pandemic is an unprecedented global challenge. Highly variable in its presentation, spread and clinical outcome, novel point-of-care diagnostic classifiers are urgently required. Here, we describe a set of COVID-19 clinical classifiers discovered using a newly designed low-cost high-throughput mass spectrometry-based platform. Introducing a new sample preparation pipeline coupled with short-gradient high-flow liquid chromatography and mass spectrometry, our methodology facilitates c...
#1Jure Mur (Edin.: University of Edinburgh)
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last. Kathryn L. Evans (Edin.: University of Edinburgh)H-Index: 20
view all 11 authors...
Introduction: Genetic variation in the apolipoprotein E (APOE) gene is associated with Alzheimer's disease (AD) and risk factors for cardiovascular disease (CVD). DNA methylationat APOE has been associated with altered cognition and AD. It is unclear if epigenetic marks could be used for predicting future disease. Methods: We assessed blood-based DNA methylation at 13 CpGs in the APOE gene in 5828 participants from the Generation Scotland (GS) cohort. Using linear mixed models regression, we exa...
#1Sarah Bauermeister (University of Oxford)H-Index: 5
#2Christopher Orton (Swansea University)H-Index: 1
Last. Catherine M. Calvin (University of Oxford)H-Index: 12
view all 66 authors...
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data d...
#1Rosie M. Walker (Edin.: University of Edinburgh)H-Index: 9
#2Mairead Lesley Bermingham (Edin.: University of Edinburgh)H-Index: 12
Last. Caroline Hayward (Edin.: University of Edinburgh)H-Index: 95
view all 15 authors...
INTRODUCTION: Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here, we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer9s disease (AD)-free participants. METHODS: Associations between dementia risk measures (family history, genetic risk score (GRS), and dementia risk scores (combining lifestyle, demographic and genetic factors) and whole-bl...
#1Weihua Meng (Dund.: University of Dundee)H-Index: 11
#2Brian W. Chan (Dund.: University of Dundee)
Last. Xianwei Zhang (HUST: Huazhong University of Science and Technology)
view all 16 authors...
BACKGROUND: Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify the genetic variants associated with neck or shoulder pain based on a genome-wide association approach using 203 309 subjects from the UK Biobank cohort and look for replication evidence from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and TwinsUK. METHODS: A genome-wide association study was performed adjusting for age, sex, BMI and 9 population pr...
#1Ella WigmoreH-Index: 2
Last. Mark J. AdamsH-Index: 24
view all 24 authors...
#1Anna R. Docherty (VCU: Virginia Commonwealth University)H-Index: 13
#2Andrey A. Shabalin (UofU: University of Utah)H-Index: 21
Last. Andrew M. McIntosh (Edin.: University of Edinburgh)H-Index: 75
view all 11 authors...
OBJECTIVE: Subthreshold psychosis risk symptoms in the general population may be associated with molecular genetic risk for psychosis. This study sought to optimize the association of risk symptoms with genetic risk for psychosis in a large population-based cohort in the UK (N = 9104 individuals 18-65 years of age) by properly accounting for population stratification, factor structure, and sex. METHODS: The newly expanded Generation Scotland: Scottish Family Health Study includes 5391 females an...
#1Anne Seeboth (Edin.: University of Edinburgh)H-Index: 1
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last. Sara Haegg (KI: Karolinska Institutet)H-Index: 22
view all 12 authors...
BACKGROUND: DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-quartile range from the 25th or 75th percentiles compared to the rest of the population. DNA methylation outlier burden (the number of such outlier sites per individual) increases exponentially with age. However, these findings have been observed in small samples. RESULTS: Here, w...