Curtis Cooper
Ottawa Hospital Research Institute
VirologyImmunologyHepatitis C virusHepatitis CMedicine
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Publications 1981
#1Sahar Saeed (McGill University)H-Index: 12
#2Erin Strumpf (McGill University)H-Index: 18
Last. Marina B. Klein (MUHC: McGill University Health Centre)H-Index: 48
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BACKGROUND: High costs of direct acting antivirals (DAAs) led healthcare insurers to limit access worldwide. Using a natural experiment, we evaluated the impact of removing fibrosis stage restrictions on hepatitis C (HCV) treatment initiation rates among people living with HIV and then examined who was left to be treated. METHODS: Using data from the Canadian HIV-HCV Co-Infection Cohort, we applied a difference-in-differences approach. Changes in treatment initiation rates following the removal ...
2 CitationsSource
#1Nadine Kronfli (McGill University)H-Index: 5
#1Nadine Kronfli (McGill University)
Last. Neora Pick (UBC: University of British Columbia)H-Index: 16
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BACKGROUND Noninvasive markers of liver fibrosis such as aspartate aminotransferase-to-platelet ratio (APRI) and transient elastography (TE) have largely replaced liver biopsy for staging hepatitis C virus (HCV). As there is little longitudinal data, we compared changes in these markers before and after sustained virologic response (SVR) in HIV-HCV coinfected patients. METHODS Participants from the Canadian Coinfection Cohort study who achieved SVR after a first treatment with either interferon/...
#1Claire KendallH-Index: 11
Last. Curtis Cooper (Ottawa Hospital Research Institute)H-Index: 39
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Background: Disengagement from care can affect treatment outcomes of patients with hepatitis C virus (HCV). We assessed the extent and determinants of disengagement among HCV patients receiving car...
#1Matt Driedger (U of O: University of Ottawa)H-Index: 1
#2Chrissi Galanakis (Ottawa Hospital Research Institute)H-Index: 2
Last. Curtis Cooper (U of O: University of Ottawa)H-Index: 39
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HCV infection is associated with chronic kidney disease due to several mechanisms. Patients treated with interferon-based regimens demonstrate improved renal function and reduced incidence of chronic kidney disease. There is scarce evidence on the effect of direct acting antiviral regimens (DAAs) on renal function.We evaluated serial measures of renal function in a cohort of HCV-infected participants following completion of DAA-based treatment regimens.Measures of glomerular filtration rate (GFR...
#1Andreea Adelina Artenie (UdeM: Université de Montréal)H-Index: 7
#2Evan B. Cunningham (UNSW: University of New South Wales)H-Index: 12
Last. Jason Grebely (UNSW: University of New South Wales)H-Index: 52
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BACKGROUND: In many settings, recent or prior injection drug use remain barriers to accessing direct-acting antiviral treatment (DAA) for hepatitis C virus (HCV) infection. We examined longitudinal patterns of drug and alcohol use and injection equipment sharing among people with recent injecting drug use or receiving opioid agonist treatment (OAT) during and following DAA-based treatment. METHODS: SIMPLIFY and D3FEAT are phase IV clinical trials evaluating the efficacy of DAA among people with ...
4 CitationsSource
#1Curtis Cooper (U of O: University of Ottawa)H-Index: 39
#1Edward TamH-Index: 10
Last. Gisela MacphailH-Index: 1
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Background: Canada was the first country to approve elbasvir/grazoprevir (EBR/GZR) for the treatment of chronic HCV infection for genotypes 1 and 4 with or without ribavirin and genotype 3 with sof...
#1Candis Lepage (U of O: University of Ottawa)H-Index: 1
#2Gary Garber (U of O: University of Ottawa)H-Index: 34
Last. Curtis CooperH-Index: 39
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Background: Rurally located individuals living with hepatitis C virus (HCV) face barriers to engagement and retention in care. Telemedicine technologies coupled with highly curative direct acting a...
#1Robert B. ConleyH-Index: 1
#2Gemma AdibH-Index: 2
Last. Karen Chapman-Novakofski (UIUC: University of Illinois at Urbana–Champaign)H-Index: 18
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Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to develop clinical recommendations for the optimal prevention of secondary fractureamong people aged 65 years and older with a hip or vertebral fracture. The coalition developed 13 reco...
1 CitationsSource
#1Evan B. Cunningham (UNSW: University of New South Wales)H-Index: 12
#2Behzad Hajarizadeh (UNSW: University of New South Wales)H-Index: 27
Last. Philippa Marks (UNSW: University of New South Wales)H-Index: 4
view all 23 authors...
BACKGROUND: The aim of this analysis was to calculate the incidence of HCV reinfection and associated factors among two clinical trials of HCV DAA treatment in people with recent injecting drug use or currently receiving OAT. METHODS: Participants who achieved an end-of-treatment response in two clinical trials of people with recent injecting drug use or currently receiving OAT (SIMPLIFY and D3FEAT) enrolled between March 2016 and February 2017 in eight countries were assessed for HCV reinfectio...