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Edward G. Clark
Ottawa Hospital Research Institute
Intensive care medicineRenal replacement therapyAcute kidney injuryDiabetes mellitusMedicine
62Publications
12H-index
473Citations
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Publications 63
Newest
#1Adesewa Oloko (U of O: University of Ottawa)
#2Hari Talreja (Middlemore Hospital)
Last. Swapnil Hiremath (Ottawa Hospital Research Institute)H-Index: 21
view all 8 authors...
BACKGROUND: It is important for medical practitioners to be aware of the effect of iodinated contrast media on the residual renal function (RRF) of dialysis patients who require diagnostic or therapeutic imaging procedures. Preservation of RRF is important given that it is a robust predictor of higher survival. However, the absence of any effect would allow for easier diagnostic or therapeutic imaging tests to be performed. OBJECTIVE: This systematic review with meta-analysis will quantify the e...
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#1Pierre Antoine Brown (U of O: University of Ottawa)H-Index: 5
#2Peter Magner (U of O: University of Ottawa)H-Index: 6
Last. Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
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Neuropsychiatric conditions such as depression, delirium and cognitive impairment are common in patients with end-stage kidney disease (ESKD) and individuals suffering from ESKD are more likely to commit suicide than members of the general population. Self-harm gestures are not infrequent for ESKD patients suffering from depression, but not well described in other conditions. We present a case of self-harm in a patient with ESKD suffering from acute delirium. A man in his mid-seventies was admit...
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#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Khalid Zeid (U of O: University of Ottawa)H-Index: 1
Last. Edward G. Clark (U of O: University of Ottawa)H-Index: 12
view all 9 authors...
Hemodynamic instability related to renal replacement therapy (HIRRT) is a frequent complication of all renal replacement therapy (RRT) modalities commonly used in the intensive care unit. HIRRT is associated with increased mortality and may impair kidney recovery. Our current understanding of the physiologic basis for HIRRT comes primarily from studies of end-stage kidney disease patients on maintenance hemodialysis in whom HIRRT is referred to as ‘intradialytic hypotension’. Nonetheless, there ...
2 CitationsSource
#1Richard Hae (U of O: University of Ottawa)H-Index: 1
#2Daniel Samaha (U of O: University of Ottawa)
Last. Edward G. Clark (U of O: University of Ottawa)H-Index: 12
view all 6 authors...
Background:Controversy exists as to whether the insertion of temporary hemodialysis catheters (THDCs) should remain a mandatory requirement of nephrology fellowship training in Canada. A survey con...
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#1Daniel Samaha (U of O: University of Ottawa)
#2Edward G. Clark (U of O: University of Ottawa)H-Index: 12
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#1Carol Wang (U of O: University of Ottawa)
#2Swapnil Hiremath (U of O: University of Ottawa)H-Index: 21
Last. Edward G. Clark (U of O: University of Ottawa)H-Index: 12
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Background Acute kidney injury requiring dialysis (AKI-D) during hospitalization is associated with both in-hospital and post-discharge mortality. Its incidence has risen over time in Canada and the USA. While the majority of AKI-D will recover to dialysis independence at the time of hospital discharge, 10–30% will transition to outpatient dialysis. The risk factors that determine dialysis independence after AKI-D and its optimal outpatient management remain unclear. Eliciting prognostic predict...
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#1J. Ariana Noel (U of O: University of Ottawa)H-Index: 2
#2Sarah E. Bota (International Council for the Exploration of the Sea)H-Index: 5
Last. Manish M. Sood (U of O: University of Ottawa)H-Index: 24
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Importance Sodium polystyrene sulfonate is commonly prescribed for the treatment of hyperkalemia. Case reports of intestinal injury after administration of sodium polystyrene sulfonate with sorbitol resulted in a US Food and Drug Administration warning and discontinuation of combined 70% sorbitol–sodium polystyrene sulfonate formulations. There are ongoing concerns about the gastrointestinal (GI) safety of sodium polystyrene sulfonate use. Objective To assess the risk of hospitalization for adve...
3 CitationsSource
#1Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
#2Swapnil Hiremath (Ottawa Hospital Research Institute)H-Index: 21
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#1Sriram Sriperumbuduri (U of O: University of Ottawa)H-Index: 1
#2Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
Last. Swapnil Hiremath (Ottawa Hospital Research Institute)H-Index: 21
view all 3 authors...
Abstract Acute kidney injury is a frequent occurrence in patients with heart disease, and is associated with higher risk of adverse outcomes, including mortality. In the setting of decompensated heart failure, acute kidney injury can occur from hemodynamic and neurohormonal activation, venous congestion, and nephrotoxic medications. Certain medications, such as loop diuretics, renin angiotensin system blockers, and mineralocorticoid antagonists can seemingly cause acute kidney injury. However, t...
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#1Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
#2Swapnil Hiremath (Ottawa Hospital Research Institute)H-Index: 21
Last. Carl van Walraven Md MSc Frcpc (U of O: University of Ottawa)H-Index: 52
view all 7 authors...
This article has been withdrawn at the request of the authors and editors because after publication of the Article in Press, the authors discovered that there had been an error in the programming of the statistical analysis. Once the error was corrected, the conclusions of the article were no longer supported. The Publisher and authors apologize for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policie...
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