Match!
Hayat Ullah
Hazara University
30Publications
14H-index
423Citations
Publications 30
Newest
#1Fazal Rahim (HU: Hazara University)H-Index: 25
#2Sundas Tariq (HU: Hazara University)
Last.Syed Adnan Ali Shah (UiTM: Universiti Teknologi MARA)H-Index: 16
view all 12 authors...
Abstract New triazinoindole bearing thiazole/oxazole analogues (1–21) were synthesized and characterized through spectroscopic techniques such as HREI-MS, 1H and 13C NMR. The configuration of compound 2i and 2k was confirmed through NOESY. All analogues were evaluated against α-amylase inhibitory potential. Among the synthesized analogues, compound 1h, 1i, 1j, 2a and 2f having IC50 values 1.80 ± 0.20, 1.90 ± 0.30, 1.2 ± 0.30, 1.2 ± 0.01 and 1.30 ± 0.20 μM respectively, showed excellent α-amylase...
Source
#1Taha MuhammadH-Index: 29
Last.Farzana NazH-Index: 5
view all 9 authors...
A new class of triazinoindole-bearing thiosemicarbazides (1–25) was synthesized and evaluated for α-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 ± 0.01 to 35.80 ± 0.80 µM when compared to standard acarbose (an IC50 value of 38.60 ± 0.20 µM). Among the series, analogs 1 and 23 were found to be the most potent, with IC50 values of 1.30 ± 0.05 and 1.30 ± 0.01 µM, respectively. The structure–activity relationsh...
Source
#1Fazal Rahim (HU: Hazara University)H-Index: 25
#2Taha MuhammadH-Index: 29
Last.Mohammed GollapalliH-Index: 5
view all 10 authors...
Abstract Alpha-amylase and urease enzyme over expression endorses various complications like rheumatoid arthritis, urinary tract infection, colon cancer, metabolic disorder, cardiovascular risk, and chronic kidney disease. To overcome these complications, we have synthesized new arylhydrazide bearing Schiff bases/thiazolidinone analogues as α-amylase and urease inhibitors. The analogues 1a-r were evaluated for α-amylase inhibitory potential. All analogues were found active and show IC 50 value r...
1 CitationsSource
#1Fazal Rahim (HU: Hazara University)H-Index: 25
#2Khalid Zaman (HU: Hazara University)H-Index: 3
Last.Khalid Mohammed Khan (KU: University of Karachi)H-Index: 48
view all 12 authors...
Abstract Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also numerous side effects. Subsequently, there is still needed to develop safer therapy. Despite of a broad spectrum of biological importance of benzimidazole, it is occasionally evaluated for α-glucosidase activity. Current study deals with the synthesis and biological screening of benzimidazole bearing bis-...
Source
#1Taha MuhammadH-Index: 29
Last.Syahrul ImranH-Index: 21
view all 7 authors...
Source
#1Khalid Zaman (HU: Hazara University)H-Index: 3
#2Fazal Rahim (HU: Hazara University)H-Index: 25
Last.Mohammed GollapalliH-Index: 5
view all 12 authors...
Abstract Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1–19 were synthesized and screened for in vitro urease inhibitory potential. Structures of all synthetic analogues were deduced by different spectroscopic techniques. All analogues revealed inhibition potential with IC50 values of 0.90 ± 0.01 to 35.20 ± 1.10 μM, when compared with the standard thiourea (IC...
2 CitationsSource
#1Hayat Ullah (HU: Hazara University)H-Index: 14
#2Fazal Rahim (HU: Hazara University)H-Index: 25
Last.Khalid Mohammed Khan (KU: University of Karachi)H-Index: 48
view all 9 authors...
Source
#2Taha MuhammadH-Index: 29
Last.Khalid Mohammed Khan (KU: University of Karachi)H-Index: 48
view all 10 authors...
Abstract In search of better α-glucosidase inhibitors, a series of bis-indolylmethane sulfonohydrazides derivatives (1-14) were synthesized and evaluated for their α-glucosidase inhibitory potential. All derivatives exhibited outstanding α-glucosidase inhibition with IC50 values ranging between 0.10 ± 0.05 to 5.1 ± 0.05 μM when compared with standard drug acarbose having IC50 value 856.28 ± 3.15 μM. Among the series, analog 7 (0.10 ± 0.05 μM) with tri-chloro substitution on phenyl ring was ident...
6 CitationsSource
#1Hayat Ullah (HU: Hazara University)H-Index: 14
#2Fazal Rahim (HU: Hazara University)H-Index: 25
Last.Khalid Mohammed Khan (KU: University of Karachi)H-Index: 48
view all 10 authors...
Abstract We have synthesized oxadiazole derivatives (1–16), characterized by 1H NMR, 13C NMR and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives display varied degree of thymidine phosphorylase inhibition in the range of 1.10 ± 0.05 to 49.60 ± 1.30 μM when compared with the standard inhibitor 7-Deazaxanthine having an IC50 value 38.68 ± 1.12 μM. Structure activity relationships (SAR) has been established for all compounds to explore the role of substitution...
11 CitationsSource
#1Taha MuhammadH-Index: 29
#2Hayat Ullah (HU: Hazara University)H-Index: 14
Last.Shahnaz PerveenH-Index: 27
view all 8 authors...
Abstract Thirty-two (32) bis -indolylmethane-hydrazone hybrids 1 – 32 were synthesized and characterized by 1 HNMR, 13 CNNMR and HREI-MS. All compounds were evaluated in vitro for β -glucuronidase inhibitory potential. All analogs showed varying degree of β -glucuronidase inhibitory potential ranging from 0.10 ± 0.01 to 48.50 ± 1.10 μ M when compared with the standard drug d -saccharic acid-1,4-lactone (IC 50 value 48.30 ± 1.20 μ M). Derivatives 1–32 showed the highest β -glucuronidase inhibitor...
13 CitationsSource
123