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Hayat Ullah
Hazara University
Docking (molecular)Organic chemistryChemistryBiochemistryStereochemistry
34Publications
17H-index
604Citations
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Publications 34
Newest
#1Imad Uddin (HU: Hazara University)H-Index: 7
#2Hayat Ullah (HU: Hazara University)H-Index: 17
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Abstract We have synthesized fifteen bis-indole bearing Schiff base derivatives (1-15) as α-glucosidase and urease inhibitors which were characterized through different spectroscopic techniques (1H, 13C-NMR, HREI-MS and FTIR). All analogs were found active when screened for α-glucosidase inhibition and showed IC50 values ranging from 18.92 ± 1.34 to 475.74 ± 1.52 µM when compared with standard acarbose (IC50 = 375.82 ± 1.76 µM). Among the series, analogs 10, 14 and 15 having IC50 values 18.92 ± ...
Source
#1Muhammad TahaH-Index: 31
#2Fazal Rahim (HU: Hazara University)H-Index: 28
Last. Zainul Amiruddin Zakaria (UPM: Universiti Putra Malaysia)H-Index: 27
view all 8 authors...
In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone analogues (1-14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and evaluated for urease inhibition. Compounds 1-14 exhibited a varying degree of urease inhibitory activity with IC50 values between 1.2 ± 0.01 to 23.50 ± 0.70 µM when compared with standard drug thiourea having IC50 value 21.40 ± 0.21 µM. Compound 1, 3, 5 and 8 showed significant inhibitory effects with IC50 values 1.2 ± 0.01, 2.20 ± 0....
Source
#1Hayat Ullah (HU: Hazara University)H-Index: 17
#2Fazal Rahim (HU: Hazara University)H-Index: 28
Last. Khalid Mohammed Khan (KU: University of Karachi)H-Index: 51
view all 13 authors...
Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases (1-18) were synthesized and evaluated for α-glucosidase inhibitory potential. Fifteen compounds 1-8, 11-13, and 15-18 showed excellent inhibition with IC50 values ranging from 0.30 ± 0.2 to 35.1 ± 0.80 µM as compared to the standard inhibitor acarbose (IC50 = 38.45 ± 0.80 µM), nonetheless, the remaining com...
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#1Fazal Rahim (HU: Hazara University)H-Index: 28
#2Khalid Zaman (HU: Hazara University)H-Index: 5
Last. Khalid Mohammed Khan (KU: University of Karachi)H-Index: 51
view all 12 authors...
Abstract Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also numerous side effects. Subsequently, there is still needed to develop safer therapy. Despite of a broad spectrum of biological importance of benzimidazole, it is occasionally evaluated for α-glucosidase activity. Current study deals with the synthesis and biological screening of benzimidazole bearing bis-...
3 CitationsSource
#1Fazal Rahim (HU: Hazara University)H-Index: 28
#2Sundas Tariq (HU: Hazara University)H-Index: 1
Last. Syed Adnan Ali Shah (UiTM: Universiti Teknologi MARA)H-Index: 16
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Abstract New triazinoindole bearing thiazole/oxazole analogues (1–21) were synthesized and characterized through spectroscopic techniques such as HREI-MS, 1H and 13C NMR. The configuration of compound 2i and 2k was confirmed through NOESY. All analogues were evaluated against α-amylase inhibitory potential. Among the synthesized analogues, compound 1h, 1i, 1j, 2a and 2f having IC50 values 1.80 ± 0.20, 1.90 ± 0.30, 1.2 ± 0.30, 1.2 ± 0.01 and 1.30 ± 0.20 μM respectively, showed excellent α-amylase...
2 CitationsSource
#1Muhammad TahaH-Index: 31
Last. Farzana NazH-Index: 5
view all 9 authors...
A new class of triazinoindole-bearing thiosemicarbazides (1–25) was synthesized and evaluated for α-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 ± 0.01 to 35.80 ± 0.80 µM when compared to standard acarbose (an IC50 value of 38.60 ± 0.20 µM). Among the series, analogs 1 and 23 were found to be the most potent, with IC50 values of 1.30 ± 0.05 and 1.30 ± 0.01 µM, respectively. The structure–activity relationsh...
1 CitationsSource
Last. Syahrul ImranH-Index: 24
view all 7 authors...
Source
#1Khalid Zaman (HU: Hazara University)H-Index: 5
#2Fazal Rahim (HU: Hazara University)H-Index: 28
Last. Mohammed GollapalliH-Index: 5
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Abstract Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1–19 were synthesized and screened for in vitro urease inhibitory potential. Structures of all synthetic analogues were deduced by different spectroscopic techniques. All analogues revealed inhibition potential with IC50 values of 0.90 ± 0.01 to 35.20 ± 1.10 μM, when compared with the standard thiourea (IC...
9 CitationsSource
#1Fazal Rahim (HU: Hazara University)H-Index: 28
Last. Mohammed GollapalliH-Index: 5
view all 10 authors...
Abstract Alpha-amylase and urease enzyme over expression endorses various complications like rheumatoid arthritis, urinary tract infection, colon cancer, metabolic disorder, cardiovascular risk, and chronic kidney disease. To overcome these complications, we have synthesized new arylhydrazide bearing Schiff bases/thiazolidinone analogues as α-amylase and urease inhibitors. The analogues 1a-r were evaluated for α-amylase inhibitory potential. All analogues were found active and show IC 50 value r...
7 CitationsSource
#1Hayat Ullah (HU: Hazara University)H-Index: 17
#2Fazal Rahim (HU: Hazara University)H-Index: 28
Last. Khalid Mohammed Khan (KU: University of Karachi)H-Index: 51
view all 9 authors...
BACKGROUND: In the recent past, we had synthesized and reported different derivatives of oxadiazoles as potential α-glucosidase inhibitors. Keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on the chemistry and bioactivity of new heterocyclic compounds. METHOD: 1,3,4-Oxadiazole derivatives (1-14) have been synthesized and characterized by different spectroscopic techniques such as 1H-, 13C-NMR and HREI-MS. RESULT: The synthetic derivati...
1 CitationsSource
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