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A. J. Rush
University of Texas Southwestern Medical Center
603Publications
112H-index
53.5kCitations
Publications 603
Newest
Published on Dec 1, 2019in Translational Psychiatry5.18
Sudeepa Bhattacharyya13
Estimated H-index: 13
(University of Arkansas for Medical Sciences),
Ahmed T. Ahmed10
Estimated H-index: 10
(Mayo Clinic)
+ 13 AuthorsBoadie W. Dunlop26
Estimated H-index: 26
(Emory University)
Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on a set of 31 metabolites from neurotransmitter-related pathways. Overall, 290 unipolar patients with major depressive disorder were profiled at baseline, after 4 and 8 weeks of drug treatment. The 17-i...
Published on Dec 1, 2019in Translational Psychiatry5.18
Sarah C. Hellewell5
Estimated H-index: 5
(USYD: University of Sydney),
Thomas Welton3
Estimated H-index: 3
(USYD: University of Sydney)
+ 7 AuthorsStuart M. Grieve37
Estimated H-index: 37
(USYD: University of Sydney)
Reduced gray matter (GM) volume may represent a hallmark of major depressive disorder (MDD) neuropathology, typified by wide-ranging distribution of structural alteration. In the study, we aimed to replicate and extend our previous finding of profound and widespread GM loss in MDD, and evaluate the diagnostic accuracy of a structural biomarker derived from GM volume in an interconnected pattern across the brain. In a sub-study of the International Study to Predict Optimized Treatment in Depressi...
Published on Jan 30, 2019in Addiction6.85
John Marsden49
Estimated H-index: 49
('KCL': King's College London),
Betty Tai15
Estimated H-index: 15
(NIDA: National Institute on Drug Abuse)
+ 3 AuthorsNora D. Volkow139
Estimated H-index: 139
(NIDA: National Institute on Drug Abuse)
CONTEXT AND PURPOSE: Measurement-based care (MBC) is an evidence-based health-care practice in which indicators of disease are tracked to inform clinical actions, provide feedback to patients and improve outcomes. The current opioid crisis in multiple countries provides a pressing rationale for adopting a basic MBC approach for opioid use disorder (OUD) using DSM-5 to increase treatment retention and effectiveness. PROPOSAL: To stimulate debate, we propose a basic MBC approach using the 11 sympt...
Published on Jul 1, 2019in Annals of Family Medicine4.18
Manish K. Jha7
Estimated H-index: 7
,
Bruce D. Grannemann25
Estimated H-index: 25
+ 6 AuthorsMadhukar H. Trivedi89
Estimated H-index: 89
Published on May 14, 2019in Pharmaceuticals
Madhukar H. Trivedi89
Estimated H-index: 89
,
Manish K. Jha7
Estimated H-index: 7
+ 10 AuthorsBruce D. Grannemann25
Estimated H-index: 25
Major depressive disorder affects one in five adults in the United States. While practice guidelines recommend universal screening for depression in primary care settings, clinical outcomes suffer in the absence of optimal models to manage those who screen positive for depression. The current practice of employing additional mental health professionals perpetuates the assumption that primary care providers (PCP) cannot effectively manage depression, which is not feasible, due to the added costs ...
Published on May 9, 2019in bioRxiv
Ahmed T. Ahmed10
Estimated H-index: 10
(Mayo Clinic),
Siamak MahmoudianDehkordi3
Estimated H-index: 3
(Duke University)
+ 20 AuthorsGregory Louie3
Estimated H-index: 3
(Duke University)
Background: Acylcarnitines have important functions in mitochondrial energetics and β-oxidation, and have been implicated to play a significant role in metabolic functions of the brain. This retrospective study examined whether plasma acylcarnitine profiles can help biochemically distinguish the three phenotypic subtypes of major depressive disorder (MDD) ,(core depression (CD+), anxious depression (ANX+), and neurovegetative symptoms of melancholia (NVSM+)),following treatment with a selective ...
Published on May 1, 2019in American Journal of Psychiatry13.65
Manish K. Jha7
Estimated H-index: 7
,
Abu Minhajuddin20
Estimated H-index: 20
+ 2 AuthorsMadhukar H. Trivedi89
Estimated H-index: 89
Objective:The authors evaluated improvement in irritability with antidepressant treatment and its prognostic utility in treatment-seeking adult outpatients with major depressive disorder.Methods:Mixed-model analyses were used to assess changes in irritability (as measured with the five-item irritability domain of the Concise Associated Symptom Tracking [CAST-IRR] scale) from baseline to week 4 after controlling for depression severity (as measured with the 16-item Quick Inventory of Depressive S...
Published on May 1, 2019in The International Journal of Neuropsychopharmacology4.21
Manish K. Jha7
Estimated H-index: 7
(ISMMS: Icahn School of Medicine at Mount Sinai),
Charles South2
Estimated H-index: 2
(UTSW: University of Texas Southwestern Medical Center)
+ 3 AuthorsMadhukar H. Trivedi89
Estimated H-index: 89
(UTSW: University of Texas Southwestern Medical Center)
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