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A. J. Rush
University of Texas Southwestern Medical Center
696Publications
118H-index
61.1kCitations
Publications 698
Newest
#1Ahmed T. Ahmed (Mayo Clinic)H-Index: 11
#2Siamak Mahmoudiandehkordi (Duke University)H-Index: 2
Last.Rima Kaddurah-Daouk (Duke University)H-Index: 43
view all 23 authors...
Abstract Background Acylcarnitines have important functions in mitochondrial energetics and β-oxidation, and have been implicated to play a significant role in metabolic functions of the brain. This retrospective study examined whether plasma acylcarnitine profiles can help biochemically distinguish the three phenotypic subtypes of major depressive disorder (MDD): core depression (CD+), anxious depression (ANX+), and neurovegetative symptoms of melancholia (NVSM+). Methods Depressed outpatients ...
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#1Siamak Mahmoudiandehkordi (Duke University)H-Index: 2
#2Ahmed T. Ahmed (Mayo Clinic)H-Index: 11
Last.J. Will Thompson (Duke University)H-Index: 28
view all 20 authors...
Selective serotonin reuptake inhibitors (SSRIs) are the first line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metabolomics approach utilizing a panel of 180 metabolites to gain insights into mechanisms of action and response to citalopram/escitalopram. Plasma samples from 136 participants with MDD enrolled into the Mayo Pharmacogenomics Research Network Antidepre...
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#1Sudeepa Bhattacharyya (University of Arkansas for Medical Sciences)H-Index: 14
#2Ahmed T. Ahmed (Mayo Clinic)H-Index: 11
Last.Rima Kaddurah-Daouk (Duke University)H-Index: 43
view all 16 authors...
Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on a set of 31 metabolites from neurotransmitter-related pathways. Overall, 290 unipolar patients with major depressive disorder were profiled at baseline, after 4 and 8 weeks of drug treatment. The 17-i...
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#1Sarah C. Hellewell (USYD: University of Sydney)H-Index: 6
#2Thomas Welton (USYD: University of Sydney)H-Index: 3
Last.Stuart M. Grieve (USYD: University of Sydney)H-Index: 37
view all 10 authors...
Reduced gray matter (GM) volume may represent a hallmark of major depressive disorder (MDD) neuropathology, typified by wide-ranging distribution of structural alteration. In the study, we aimed to replicate and extend our previous finding of profound and widespread GM loss in MDD, and evaluate the diagnostic accuracy of a structural biomarker derived from GM volume in an interconnected pattern across the brain. In a sub-study of the International Study to Predict Optimized Treatment in Depressi...
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#1Arjun P. Athreya (UIUC: University of Illinois at Urbana–Champaign)H-Index: 6
#2Drew Neavin (Mayo Clinic)H-Index: 4
Last.William V. Bobo (Mayo Clinic)H-Index: 25
view all 12 authors...
5 CitationsSource
#1Sudeepa Bhattacharyya (University of Arkansas for Medical Sciences)H-Index: 14
#2Boadie W. Dunlop (Emory University)H-Index: 27
Last.Rima Kaddurah-Daouk (Duke University)H-Index: 43
view all 12 authors...
Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to the severity of depressive symptoms, so-called "state-dependent" biomarkers of depression, this pilot study explored the biochemical underpinnings of treatment response to cognitive behavior therapy (CBT) in medication-freeMDD outpatients. Plasma samp...
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#1John Marsden ('KCL': King's College London)H-Index: 53
#2Betty Tai (NIDA: National Institute on Drug Abuse)H-Index: 15
Last.Nora D. Volkow (NIDA: National Institute on Drug Abuse)H-Index: 141
view all 6 authors...
CONTEXT AND PURPOSE: Measurement-based care (MBC) is an evidence-based health-care practice in which indicators of disease are tracked to inform clinical actions, provide feedback to patients and improve outcomes. The current opioid crisis in multiple countries provides a pressing rationale for adopting a basic MBC approach for opioid use disorder (OUD) using DSM-5 to increase treatment retention and effectiveness. PROPOSAL: To stimulate debate, we propose a basic MBC approach using the 11 sympt...
4 CitationsSource
#1Manish K. JhaH-Index: 9
#2Bruce D. GrannemannH-Index: 25
Last.Madhukar H. TrivediH-Index: 91
view all 9 authors...
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#1Sudeepa Bhattacharyya (University of Arkansas for Medical Sciences)H-Index: 14
#2Boadie W. Dunlop (Emory University)H-Index: 27
Last.Rima Kaddurah-Daouk (Duke University)H-Index: 43
view all 12 authors...
Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to the severity of depressive symptoms, so-called "state-dependent" biomarkers of depression, this pilot study explored the biochemical underpinnings of treatment response to cognitive behavior therapy (CBT) in medication-freeMDD outpatients. Plasma samp...
Source
#1Harold A. Sackeim (Columbia University)H-Index: 75
#2Scott Aaronson (UMB: University of Maryland, Baltimore)H-Index: 35
Last.A. J. Rush (TTU: Texas Tech University)H-Index: 118
view all 9 authors...
Abstract There is considerable diversity in how treatment-resistant depression (TRD) is defined. However, every definition incorporates the concept that patients with TRD have not benefited sufficiently from one or more adequate trials of antidepressant treatment. This review examines the issues fundamental to the systematic evaluation of antidepressant treatment adequacy and resistance. These issues include the domains of interventions deemed effective in treatment of major depressive episodes ...
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