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Maqsudul Alam
University of Hawaii
GlobinGenomeGeneticsBiochemistryBiology
108Publications
37H-index
6,121Citations
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Publications 98
Newest
Deciphering genetic information through next-generation sequencing (NGS) is considered as the basic platform to unveil in details of an organism. However, as it produces short reads that lead to difficulties in assembly, we generated long scaffold-based optical mapping (OM) data of previously sequenced devastating fungus, Macrophomina phaseolina MS6. In the process, KpnI identified as the most effective restriction endonuclease among tested 13, used to digest high molecular weight (HMW) DNA that...
Source
#1Xuehua Wan (UH: University of Hawaii)H-Index: 8
#2Jennifer A. Saito (UH: University of Hawaii)H-Index: 15
Last. Maqsudul Alam (UH: University of Hawaii)H-Index: 37
view all 5 authors...
Globin-coupled diguanylate cyclases contain globin, middle, and diguanylate cyclase domains that sense O2 to synthesize c-di-GMP and regulate bacterial motility, biofilm formation, and virulence. However, relatively few studies have extensively examined the roles of individual residues and domains of globin-coupled diguanylate cyclases, which can shed light on their signaling mechanisms and provide drug targets. Here, we report the critical residues of two globin-coupled diguanylate cyclases, Ec...
Source
#1Mohammed Shahidul Islam (Bangladesh Jute Research Institute)H-Index: 2
#2Jennifer A. Saito (UH: University of Hawaii)H-Index: 15
Last. Mohammad Taufiq Alam (UH: University of Hawaii)H-Index: 2
view all 50 authors...
Jute (Corchorus sp.) is one of the most important sources of natural fibre, covering ∼80% of global bast fibre production1. Only Corchorus olitorius and Corchorus capsularis are commercially cultivated, though there are more than 100 Corchorus species2 in the Malvaceae family. Here we describe high-quality draft genomes of these two species and their comparisons at the functional genomics level to support tailor-designed breeding. The assemblies cover 91.6% and 82.2% of the estimated genome size...
19 CitationsSource
#1Beng Soon Teh (Universiti Sains Malaysia)H-Index: 1
#2Nyok-Sean Lau (Universiti Sains Malaysia)H-Index: 10
Last. Maqsudul Alam (UH: University of Hawaii)H-Index: 37
view all 10 authors...
Thermus sp. strain CCB_US3_UF1 is a thermophilic bacterium of the genus Thermus, a member of the family Thermaceae. Members of the genus Thermus have been widely used as a biological model for structural biology studies and to understand the mechanism of microbial adaptation under thermal environments. Here, we present the complete genome sequence of Thermus sp. CCB_US3_UF1 isolated from a hot spring in Malaysia, which is the fifth member of the genus Thermus with a completely sequenced and publ...
3 CitationsSource
A Gram-negative, helical bacterium designated PH27AT was cultivated from an anchialine pool on Pearl and Hermes Atoll, Northwestern Hawaiian Islands. The obligately halophilic strain was motile by bipolar tufts of flagella and grew optimally at pH 7, and microaerobically or aerobically. Closest neighbours based on 16S rRNA gene nucleotide sequence identity are Marinospirillum celere v1c_Sn-redT (93.31 %) and M. alkaliphilum Z4T (92.10 %) in the family Oceanospirillaceae, class Gammaproteobacteri...
3 CitationsSource
#1Xuehua Wan (UH: University of Hawaii)H-Index: 8
#2Shaobin Hou (UH: University of Hawaii)H-Index: 25
Last. Maqsudul Alam (UH: University of Hawaii)H-Index: 37
view all 6 authors...
ABSTRACT Most Pantoea spp. have been isolated from plant sources or clinical samples. However, we cultivated Pantoea anthophila 11-2 from hypersaline water from the lake on Laysan, Northwestern Hawaiian Islands. Draft genome sequencing of 11-2 provides a molecular basis for studies in evolution and pathogenicity in Pantoea spp.
7 CitationsSource
#1Aik-Hong TehH-Index: 7
#2Jennifer A. SaitoH-Index: 15
Last. Maqsudul AlamH-Index: 37
view all 4 authors...
Globins are haem-binding proteins with a conserved fold made up of α-helices and can possess diverse properties. A putative globin-coupled sensor from Methylacidiphilum infernorum, HGbRL, contains an N-terminal globin domain whose open and closed structures reveal an untypical dimeric architecture. Helices E and F fuse into an elongated helix, resulting in a novel site-swapped globin fold made up of helices A–E, hence the distal site, from one subunit and helices F–H, the proximal site, from ano...
2 CitationsSource
#1Sheri-Ann Tan (Universiti Sains Malaysia)H-Index: 2
#2Luis Goya (CSIC: Spanish National Research Council)H-Index: 39
Last. V. Navaratnam (Universiti Sains Malaysia)H-Index: 21
view all 6 authors...
Abstract Extract from papaya leaves, a waste material from fruit farms in Malaysia was previously reported to possess remarkable antioxidative activities. In this study, papaya leaf extract was separated into fractions of different polarities [petroleum ether (PE), ethyl acetate (EA), n -butanol (NB) and water (W) fractions]. The aim of this research was to determine the most active fraction in terms of its chemopreventive effects towards oxidative stress and the chemical constituents involved. ...
3 CitationsSource
#1Farrukh Jamil (Universiti Sains Malaysia)H-Index: 1
#2Aik-Hong Teh (Universiti Sains Malaysia)H-Index: 7
Last. Maqsudul Alam (UH: University of Hawaii)H-Index: 37
view all 6 authors...
2 CitationsSource
#1Azat Mukhametov (Universiti Sains Malaysia)H-Index: 1
#2E. Irene Newhouse (UH: University of Hawaii)H-Index: 1
Last. Maqsudul Alam (Universiti Sains Malaysia)H-Index: 37
view all 5 authors...
Abstract The allosteric pocket of the Dengue virus (DENV2) NS2B/NS3 protease, which is proximal to its catalytic triad, represents a promising drug target (Othman et al., 2008). We have explored this binding site through large-scale virtual screening and molecular dynamics simulations followed by calculations of binding free energy. We propose two mechanisms for enzyme inhibition. A ligand may either destabilize electronic density or create steric effects relating to the catalytic triad residues...
11 CitationsSource
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