Naoki Uchida
Showa University
Publications 48
#1Kei Sakamoto (AstraZeneca)
#2Shunji MatsukiH-Index: 10
Last.Song Ren (AstraZeneca)
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#1Daisuke Miyatake (Astellas Pharma)
#2Tomohisa Shibata (Astellas Pharma)H-Index: 1
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#1Ken Iseri (Showa University)H-Index: 4
#2Makoto Watanabe (Showa University)H-Index: 4
Last.Takanori Shibata (Showa University)H-Index: 15
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#1Taigi Yamazaki (Showa University)
#2Takehiko Sambe (Showa University)H-Index: 4
Last.Naoki Uchida (Showa University)H-Index: 9
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#1Daisuke Ichikura (Showa University)
#2Shuichi Nawata (Showa University)H-Index: 3
Last.Tadanori Sasaki (Showa University)
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#1Tetsuya Sasaki (Showa University)H-Index: 2
#2Takehiko Sambe (Showa University)H-Index: 4
Last.Shinichi Kobayashi (Showa University)H-Index: 3
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#1Miho Yamada (Showa University)H-Index: 2
#2Xiao-Pen Lee (Showa University)H-Index: 19
Last.Keizo Sato (Showa University)H-Index: 9
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Abstract A highly sensitive method was developed for the analysis of alendronate in human plasma and dialysate using MonoSpin™ SAX ® extraction and metal-free high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) following methylation with trimethylsilyldiazomethane. The chromatographic separation of the derivatives for alendronate and alendronate- d 6 was achieved on an L-column2 ODS metal-free column (50 mm × 2 mm i.d., particle size 3 µm) with a linear gradient elutio...
4 CitationsSource
#1Kei SakamotoH-Index: 2
#2Shunji MatsukiH-Index: 10
Last.Alan R. Kugler (AstraZeneca)H-Index: 8
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Lanabecestat (AZD3293; LY3314814) is an orally active potent inhibitor of human β-secretase 1 in clinical development for the treatment of Alzheimer disease. In this first Japanese clinical study for an Alzheimer disease intervention to include cerebrospinal fluid (CSF) sampling in Japanese elderly healthy subjects, we report the pharmacokinetics and effects on plasma and CSF amyloid-β (Aβ) peptides of lanabecestat in a phase 1 study involving 40 healthy Japanese subjects (NCT02005211). No safet...
15 CitationsSource
#1Momoko Kawakami (Showa University)H-Index: 1
#2Sachiko Takenoshita-Nakaya (Showa University)H-Index: 1
Last.Naoki Matsumoto (St. Marianna University School of Medicine)H-Index: 17
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1 CitationsSource