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Huanwen Wu
Peking Union Medical College Hospital
22Publications
7H-index
126Citations
Publications 23
Newest
This study is to compare the surgical outcomes of patients undergoing cold knife conization (CKC) versus electrosurgical conization (ESC). Among 10,086 patients in a single center admitted between January 2000 and January 2019, CKS or ESC was used for grade 3 cervical intraepithelial neoplasia (CIN3) or more severe lesions. Modified Sturmdorf or Figure-of-eight sutures were applied after conization. A regression model was used to determine the risk factors for margin involvement and short-term p...
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#1Ran Zhu (Peking Union Medical College Hospital)
#2Huanwen Wu (Peking Union Medical College Hospital)H-Index: 7
Last.Zhen Huo (Peking Union Medical College Hospital)H-Index: 6
view all 5 authors...
Background Primary grade 2 neuroendocrine tumors of the cervix in female patients are rare and have a highly aggressive clinical course. This study is aimed to analyse the diagnosis, genetic changes, management and prognosis of these tumors and investigate whether the genetic alterations could provide more useful information to guide the molecular characterization and potential individualized treatment of grade 2 cervical neuroendocrine tumors.
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Encapsulated papillary carcinoma (EPC) of the breast is typically of low-to-intermediate grade (LTIG) with favorable prognosis. Rarely, high-grade (HG) EPC cases have been documented in recent years. Herein we compared the morphological, immunohistochemical, and clinical features of LTIG EPC to those of HG EPC. Of the 30 EPC patients, 25 were diagnosed as LTIG and five as HG (median age: 60 and 36 years, respectively); 80% of the HG EPCs exhibited predominantly solid architecture with prominent ...
#1Xiaolong Liang (Peking Union Medical College Hospital)H-Index: 2
#2Jian Sun (Peking Union Medical College Hospital)H-Index: 7
Last.Tonghua Liu (Peking Union Medical College Hospital)H-Index: 12
view all 10 authors...
Background Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The present study aimed to explore PD-L1 expression in PDAC cases in a large Chinese cohort using an in vitro diagnostic (IVD) assay to provide further insight into the potential value of programmed cell death protein 1 (PD-1) as a therapeutic target.
2 CitationsSource
#1Xinyu Ren (Peking Union Medical College Hospital)H-Index: 5
#2Huanwen Wu (Peking Union Medical College Hospital)H-Index: 7
Last.Zhi-YongLiang (Peking Union Medical College Hospital)H-Index: 14
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ABSTRACTTo determine PD1/PDL1 expression status in triple-negative breast cancer (TNBC) at both protein and mRNA levels, and to analyze the relationship between their expression and clinical parameters of the TNBC patients.Immunohistochemistry and RNAscope were used to semi quantitively evaluate PD1/PDL1 protein and mRNA expression in 195 TNBC cases on tissue microarrays. Tumor infiltrating lymphocyte (TILs) abundance was assessed using hematoxylin-eosin staining. Both tumor cells and TILs expre...
6 CitationsSource
#1Qiang MaH-Index: 1
#2Xiuxiu WuH-Index: 1
Last.Tonghua LiuH-Index: 12
view all 8 authors...
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#1Lili Wang (Peking Union Medical College Hospital)H-Index: 2
#2Junliang Lu (Peking Union Medical College Hospital)H-Index: 7
Last.Tonghua Liu (Peking Union Medical College Hospital)H-Index: 12
view all 7 authors...
Background Adaptor proteins bridge the gap between cell surface receptors and their downstream signaling elements. The clinicopathological and prognostic values of adaptor proteins remain poorly understood. The purpose of the present study was to explore the expression and prognostic value of three adaptor proteins: GRB2-associated binding protein 2 (GAB2), CRK-like protein (CRKL) and fibroblast growth factor receptor substrate 2 (FRS2) in pancreatic ductal adenocarcinoma (PDAC).
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#1Chao LiuH-Index: 2
#2En-Dong LiuH-Index: 3
Last.ChangyanLiH-Index: 11
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// Chao Liu 1, 2, * , En-Dong Liu 2, * , Yun-Xiao Meng 3, * , Xiao-Ming Dong 4 , Ya-Lan Bi 3 , Huan-Wen Wu 3 , Yan-Chao Jin 2 , Ke Zhao 2 , Jian-Jie Li 5 , Miao Yu 2 , Yi-Qun Zhan 2 , Hui Chen 2 , Chang-Hui Ge 2 , Xiao-Ming Yang 1, 2, 4 and Chang-Yan Li 1, 2 1 An Hui Medical University, Hefei, 230032, China 2 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, 100850, China 3 Department of Pathology, Peking Union Medical College...
4 CitationsSource
#1Qiang MaH-Index: 1
#2Xiuxiu WuH-Index: 1
Last.Tonghua LiH-Index: 1
view all 8 authors...
// Qiang Ma 1, * , Xiuxiu Wu 2, * , Jing Wu 3 , Huanwen Wu 1 , Ying Xiao 1 , Lili Wang 1 , Zhiyong Liang 1 and Tonghua Liu 1 1 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P. R. China 2 Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P. R. China 3 Department of Medical Imaging, Bei...
1 CitationsSource
#1Lianghong TengH-Index: 3
#2Wanglong DengH-Index: 1
Last.Zhiyong LiangH-Index: 7
view all 12 authors...
// Lianghong Teng 1, 2 , Wanglong Deng 3 , Junliang Lu 1 , Jing Zhang 1 , Xinyu Ren 1 , Huanli Duan 1 , Shannon Chuai 3 , Feidie Duan 3 , Wei Gao 2 , Tao Lu 1 , Huanwen Wu 1 , Zhiyong Liang 1 1 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China 2 Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China 3 Burning Rock Biotech Co. Ltd., Guangzhou, China Correspondence to: Zhiyong Liang, email: liangzhiyong1...
10 CitationsSource
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