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Jee Hoon Roh
Washington University in St. Louis
12Publications
5H-index
1,009Citations
Publications 12
Newest
#1Jihye HwangH-Index: 3
#2Chan Mi KimH-Index: 2
Last.Duk L. NaH-Index: 16
view all 9 authors...
Introduction: Recent studies have shown that pathologically defined subtypes of Alzheimer’s disease (AD) represent distinctive atrophy patterns and clinical characteristics. We investigated whether a cortical thickness–based clustering method can reflect such findings. Methods: Atotalof77ADsubjectsfromtheAlzheimer’sDiseaseNeuroimagingInitiative2datasetwho underwent 3-T magnetic resonance imaging, [ 18 F]-fluorodeoxyglucose-positron emission tomography (PET), [ 18 F]-Florbetapir PET, and cerebros...
#1Jee Hoon RohH-Index: 5
#2Hong JiangH-Index: 28
Last.David M. HoltzmanH-Index: 136
view all 12 authors...
2 CitationsSource
#1Jee Hoon Roh (UOU: University of Ulsan)H-Index: 5
#2Hong Jiang (WashU: Washington University in St. Louis)H-Index: 28
Last.David M. Holtzman (WashU: Washington University in St. Louis)H-Index: 136
view all 12 authors...
Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer’s disease (AD) pathogenesis, and it disrupts the sleep–wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD. However, how the amount and quality of sleep affects Aβ aggregation is not yet well understood. Orexins (hypocretins) initiate and maintain wakefulness, and loss...
81 CitationsSource
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins are expressed throughout the brain, though it is unknown whether these proteins modulate brain homeostasis. We observed that deletion of circadian clock transcriptional activators aryl hydrocarbon receptor nuclear translocator–like (Bmal1) alone, or circadian locomotor output cy...
157 CitationsSource
#1Sang Won Seo (SMC: Samsung Medical Center)H-Index: 31
#2Jung Il Lee (SMC: Samsung Medical Center)H-Index: 2
Last.Duk L. Na (SMC: Samsung Medical Center)H-Index: 42
view all 10 authors...
2 CitationsSource
#1Jee Hoon Roh (WashU: Washington University in St. Louis)H-Index: 5
#2Ashish Heda (WashU: Washington University in St. Louis)H-Index: 2
Last.David M. Holtzman (WashU: Washington University in St. Louis)H-Index: 136
view all 7 authors...
Source
#1Jasbir S. DalalH-Index: 8
#2Jee Hoon Roh (WashU: Washington University in St. Louis)H-Index: 5
Last.Joseph D. DoughertyH-Index: 24
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Hypocretin (orexin; Hcrt)-containing neurons of the hypothalamus are essential for the normal regulation of sleep and wake behaviors and have been implicated in feeding, anxiety, depression, and reward. The absence of these neurons causes narcolepsy in humans and model organisms. However, little is known about the molecular phenotype of these cells; previous attempts at comprehensive profiling had only limited sensitivity or were inaccurate. We generated a Hcrt translating ribosome affinity puri...
65 CitationsSource
#1Jasbir S. DalalH-Index: 8
#2Jee Hoon RohH-Index: 5
Last.Susan E. MaloneyH-Index: 12
view all 3 authors...
#1Jee Hoon Roh (WashU: Washington University in St. Louis)H-Index: 5
#2David M. Holtzman (WashU: Washington University in St. Louis)H-Index: 136
Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron , DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.
3 CitationsSource
#1Jee Hoon Roh (WashU: Washington University in St. Louis)H-Index: 5
#2Yafei Huang (WashU: Washington University in St. Louis)H-Index: 5
Last.David M. HoltzmanH-Index: 136
view all 7 authors...
Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of Alzheimer’s disease (AD). Before Aβ aggregation, concentrations of extracellular soluble Aβ in the interstitial fluid (ISF) space of the brain, which are regulated by neuronal activity and the sleep-wake cycle, correlate with the amount of Aβ deposition in the brain seen later. The amount and quality of sleep decline with normal aging and to a greater extent in AD patients. How sleep quality as well as ...
225 CitationsSource
12