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Jee Hoon Roh
Washington University in St. Louis
13Publications
5H-index
916Citations
Publications 13
Newest
Published on Jan 1, 2016
Jihye Hwang3
Estimated H-index: 3
,
Chan Mi Kim2
Estimated H-index: 2
+ 6 AuthorsDuk L. Na42
Estimated H-index: 42
Introduction: Recent studies have shown that pathologically defined subtypes of Alzheimer’s disease (AD) represent distinctive atrophy patterns and clinical characteristics. We investigated whether a cortical thickness–based clustering method can reflect such findings. Methods: Atotalof77ADsubjectsfromtheAlzheimer’sDiseaseNeuroimagingInitiative2datasetwho underwent 3-T magnetic resonance imaging, [ 18 F]-fluorodeoxyglucose-positron emission tomography (PET), [ 18 F]-Florbetapir PET, and cerebros...
Published on Dec 15, 2014in Journal of Experimental Medicine 10.89
Jee Hoon Roh5
Estimated H-index: 5
(UOU: University of Ulsan),
Hong Jiang24
Estimated H-index: 24
(WashU: Washington University in St. Louis)
+ 9 AuthorsMasashi Yanagisawa120
Estimated H-index: 120
(UTSW: University of Texas Southwestern Medical Center)
Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer’s disease (AD) pathogenesis, and it disrupts the sleep–wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD. However, how the amount and quality of sleep affects Aβ aggregation is not yet well understood. Orexins (hypocretins) initiate and maintain wakefulness, and loss...
Published on Dec 2, 2013in Journal of Clinical Investigation 12.28
Erik S. Musiek25
Estimated H-index: 25
,
Miranda M. Lim5
Estimated H-index: 5
+ 15 AuthorsJoseph P. Culver44
Estimated H-index: 44
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins are expressed throughout the brain, though it is unknown whether these proteins modulate brain homeostasis. We observed that deletion of circadian clock transcriptional activators aryl hydrocarbon receptor nuclear translocator–like (Bmal1) alone, or circadian locomotor output cy...
Published on Jul 1, 2013in Alzheimers & Dementia 14.42
Sang Won Seo30
Estimated H-index: 30
(SMC: Samsung Medical Center),
Jung Il Lee2
Estimated H-index: 2
(SMC: Samsung Medical Center)
+ 7 AuthorsDuk L. Na42
Estimated H-index: 42
(SMC: Samsung Medical Center)
Published on Jul 1, 2013in Alzheimers & Dementia 14.42
Jee Hoon Roh5
Estimated H-index: 5
(WashU: Washington University in St. Louis),
Ashish Heda1
Estimated H-index: 1
(WashU: Washington University in St. Louis)
+ 4 AuthorsDavid M. Holtzman118
Estimated H-index: 118
(WashU: Washington University in St. Louis)
Published on Mar 1, 2013in Genes & Development 8.99
Jasbir S. Dalal7
Estimated H-index: 7
,
Jee Hoon Roh5
Estimated H-index: 5
(WashU: Washington University in St. Louis)
+ 10 AuthorsPaul A. Gray22
Estimated H-index: 22
(WashU: Washington University in St. Louis)
Hypocretin (orexin; Hcrt)-containing neurons of the hypothalamus are essential for the normal regulation of sleep and wake behaviors and have been implicated in feeding, anxiety, depression, and reward. The absence of these neurons causes narcolepsy in humans and model organisms. However, little is known about the molecular phenotype of these cells; previous attempts at comprehensive profiling had only limited sensitivity or were inaccurate. We generated a Hcrt translating ribosome affinity puri...
Published on Jan 1, 2013
Jasbir S. Dalal7
Estimated H-index: 7
,
Jee Hoon Roh5
Estimated H-index: 5
,
Susan E. Maloney11
Estimated H-index: 11
Published on Dec 1, 2012in Neuron 14.40
Jee Hoon Roh5
Estimated H-index: 5
(WashU: Washington University in St. Louis),
David M. Holtzman118
Estimated H-index: 118
(WashU: Washington University in St. Louis)
Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron , DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.
Published on Sep 5, 2012in Science Translational Medicine 17.16
Jee Hoon Roh5
Estimated H-index: 5
(WashU: Washington University in St. Louis),
Yafei Huang5
Estimated H-index: 5
(WashU: Washington University in St. Louis)
+ 4 AuthorsDavid M. Holtzman42
Estimated H-index: 42
Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of Alzheimer’s disease (AD). Before Aβ aggregation, concentrations of extracellular soluble Aβ in the interstitial fluid (ISF) space of the brain, which are regulated by neuronal activity and the sleep-wake cycle, correlate with the amount of Aβ deposition in the brain seen later. The amount and quality of sleep decline with normal aging and to a greater extent in AD patients. How sleep quality as well as ...
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