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Saima Amin
Jamia Hamdard
BioavailabilityChemistryDrug deliveryChromatographyPharmacology
69Publications
13H-index
510Citations
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Publications 75
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Abstract Acyclovir (ACV) is an antiviral drug given as tablet that has variable and incomplete absorption from the gastrointestinal tract. Also the absorption is saturated with multi-dose regime leading to only 10-20% bioavailability. Since the drug absorption site is the upper segment of the small intestine so we hypothesised that absorption of acyclovir would increase through novel carriers such as bilosomes which are resistant to digestive enzymes disruption and offer greater drug absorption ...
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#1Md. RizwanullahH-Index: 5
Last. Saima AminH-Index: 13
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#1Sanchit Sharma (Jamia Hamdard)
#2Sanjula Baboota (Jamia Hamdard)H-Index: 34
Last. Showkat R. Mir (Jamia Hamdard)H-Index: 12
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Context: Nephrotoxicity is a renal dysfunction that arises from direct exposure to environmental chemicals or as a side effect of therapeutic drugs. Boerhaavia diffusa Linn. (Nyctaginaceae), Rheum emodi Wall. Ex. Meissn. (Polygonaceae), Nelumbo nucifera Gaertn. (Nelumbonaceae) and Crataeva nurvala Buch-Ham. (Capparidaceae) are well-recognized medicinal plants of Indian traditional system of medicine used for kidney disorders.Objectives: The present investigation was undertaken to develop a chrom...
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#1Md. Rizwanullah (Jamia Hamdard)H-Index: 5
#2Meraj Alam (Jamia Hamdard)
Last. Saima Amin (Jamia Hamdard)H-Index: 13
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At present, cancer is the most deadly disease and one of the most common causes of death worldwide providing different obstacles to chemotherapy including non-specific biodistribution of chemotherapeutic drugs, dose-related adverse effects, development of metastasis and chemoresistance. Nanoparticle-based targeted delivery of chemotherapeutics gained enormous attention in the treatment of solid tumors as they provide many significant advantages including prolonged drug release, enhanced systemic...
2 CitationsSource
#1Javed Ahamad (Jamia Hamdard)H-Index: 4
#2Naila Hassan Ali Alkefai (Jamia Hamdard)
Last. Showkat R. Mir (Jamia Hamdard)H-Index: 12
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#1Karishma Khatoon (Jamia Hamdard)
#2Rizwanullah (Jamia Hamdard)H-Index: 2
Last. Sohail Akhter (Jamia Hamdard)H-Index: 12
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Abstract Cilnidipine, a BCS class II drug is a widely prescribed antihypertensive with poor oral bioavailability. An approach to deliver the drug as flexible vesicles called transfersomes through the skin was adopted to optimise the drug delivery. A quadratic model of Box-Behnken design was used as QbD approach to analyze the effect of variables on formulation quality (example: vesicle size, entrapment efficiency and transdermal flux). The optimized composition showed small vesicle size (206.24 ...
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#1Naila Hassan Ali Alkefai (Jamia Hamdard)
#2Saima Amin (Jamia Hamdard)H-Index: 13
Last. Showkat R. Mir (Jamia Hamdard)H-Index: 12
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Abstract A mixture of gymnemic acids was precipitated from the water extract of leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. (Asclepiadaceae) by acidification with 2 N H2SO4. The chromatographic separation of the mixture afforded five new gymnemic acids (1-5). The compounds were characterized as Δ15 oleanane glycosides on the basis of extensive spectral data analysis. The compounds (1-5) showed dose dependent inhibition of α-glucosidase, which was found to be comparable to acarbose (IC50 95 ...
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#1Md. Rizwanullah (Jamia Hamdard)H-Index: 5
#2Javed AhmadH-Index: 14
Last. Mahfoozur Rahman (H.I., S.I.: University of Agriculture, Faisalabad)H-Index: 16
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#1Javed AhamadH-Index: 4
#2Showkat R. MirH-Index: 12
Last. Saima AminH-Index: 13
view all 3 authors...
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