Luo Gu
Nanjing Medical University
26Publications
13H-index
422Citations
Publications 26
Newest
Published on Sep 1, 2018in Cell Death and Disease 5.64
Shixiu Sun4
Estimated H-index: 4
(Nanjing Medical University),
Yujie Zhang9
Estimated H-index: 9
(Nanjing Medical University)
+ 9 AuthorsYongchang Chen4
Estimated H-index: 4
(Jiangsu University)
NVP-BEZ235 (BEZ235), an available dual PI3K/mTOR inhibitor, showed antitumor effect and provided a therapy strategy in carcinomas. However, the acquired upregulation of multiple receptor tyrosine kinases (RTKs) by NVP-BEZ235 in tumors limits its clinical efficacy. HDAC6, a class II histone deacetylase, is associated with expressions of multiple RTKs. The aim of this study was to detect whether co-treatment with HDAC6 inhibitor Tubastatin A (TST) would enhance the anticancer effects of BEZ235 in ...
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Published on Oct 1, 2018in Cancer management and research 3.70
Yan Chen4
Estimated H-index: 4
,
Lin Zhang1
Estimated H-index: 1
+ 6 AuthorsLuo Gu13
Estimated H-index: 13
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Published on Nov 24, 2018in International Journal of Molecular Sciences 3.69
Lin Zhang1
Estimated H-index: 1
,
Lei Liu1
Estimated H-index: 1
+ 6 AuthorsLuo Gu13
Estimated H-index: 13
Arsenic trioxide (As2O3), a traditional remedy in Chinese medicine, has been used in acute promyelocytic leukemia (APL) research and clinical treatment. Previous studies have shown that As2O3 exerts its potent antitumor effects in solid tumors by regulating cell proliferation and survival. The aim of this study was to investigate whether As2O3 inhibited gastric cancer cell migration and angiogenesis by regulating FOXO3a expression. We found that As2O3 reduced gastric cancer cell viability in a d...
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Ling Yang1
Estimated H-index: 1
(Soochow University (Taiwan)),
Yujie Zhang9
Estimated H-index: 9
(Nanjing Medical University)
+ 4 AuthorsXiaoying Zhang1
Estimated H-index: 1
Melatonin is a natural hormone involved in the regulation of circadian rhythm, immunity, and cardiovascular function. In this study, we focused on the mechanism of melatonin in the regulation of vascular permeability. We found that melatonin could inhibit both vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) induced monolayer permeability of human umbilical vein endothelial cells (HUVECs) and change the tyrosine phosphorylation of vascular endothelial cadherin (VE-cadh...
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Published on Nov 22, 2018in Frontiers in Pharmacology 3.83
Bixing Ye2
Estimated H-index: 2
(Nanjing Medical University),
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University)
+ 9 AuthorsLuo Gu13
Estimated H-index: 13
(Nanjing Medical University)
Aims: The aim of this study was to reveal the specific molecular mechanisms by which DENND1A accepts EGF signaling and activates Rab35 in gastric cancer. Methods: The expression of proteins related to DENND1A was examined by western blot analysis. Activation of Rab35 was assessed by GST-pulldown. The interaction of DENND1A and Grb2 was assessed by GST-pulldown and coimmunoprecipitation assays. The relationship between DENND1A and cell migration and invasion was detected using wound healing and t...
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Published on Aug 1, 2016in Cancer Letters 6.49
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University),
Jie Cui5
Estimated H-index: 5
(Nanjing Medical University)
+ 9 AuthorsYichao Zhu11
Estimated H-index: 11
(Nanjing Medical University)
Abstract Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in controlling cell polarization and directional migration remain elusive. Here we demonstrated GIT2 control cell polarization and direction dependent on the regulation of Golgi th...
11 Citations Source Cite
Published on Oct 1, 2016in Tumor Biology
Jie Cui5
Estimated H-index: 5
(Nanjing Medical University),
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University)
+ 7 AuthorsLuo Gu13
Estimated H-index: 13
(Nanjing Medical University)
Hypoxia-inducible factor 2α (HIF2α) plays critical roles in cancer progression. Although the mechanisms of HIF2α translation and degradation have been well studied, the mechanism for HIF2α regulation at transcriptional level is still not fully understood. Here, we present evidence that DNA methylation in promoter contributes to transcription of EPAS1 coding HIF2α. Methylated CpG binding protein 3 (MBD3) contributes to the intricate regulatory mechanism. We showed that MBD3 bound to the EPAS1 pro...
4 Citations Source Cite
Published on Dec 1, 2016in BMC Cancer 3.29
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University)
+ 7 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background Molecules Interacting with CasL (MICAL1), a multidomain flavoprotein monoxygenase, is strongly involved in the mechanisms that promote cancer cell proliferation and survival. Activation of MICAL1 causes an up-regulation of reactive oxygen species (ROS) in HeLa cells. ROS can function as a signaling molecule that modulates protein phosphorylation, leading to malignant phenotypes of cancer cells such as invasion and metastasis. Herein, we tested whether MICAL1 could control cell migrati...
16 Citations Source Cite
Published on Dec 1, 2016in Journal of Translational Medicine 4.20
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Luo Gu13
Estimated H-index: 13
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background CD24, a mucin-like membrane glycoprotein, plays a critical role in carcinogenesis, but its role in human gastric cancer and the underlying mechanism remains undefined.
15 Citations Source Cite
Published on Dec 1, 2016in Cancer Cell International 3.96
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Yujie Zhang9
Estimated H-index: 9
(Nanjing Medical University)
+ 4 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background Despite the fact that melatonin treatment shows some promise in gastric cancer, the molecular mechanisms of gastric cancer cells in response to melatonin remains to be determined.
15 Citations Source Cite
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