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Shu Yih Chew
Universiti Putra Malaysia
7Publications
4H-index
70Citations
Publications 7
Newest
#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Wallace Jeng Yang Chee (UPM: Universiti Putra Malaysia)
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 3 authors...
Background Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is often required for survival and pathogenesis. As one of the host defence strategies to combat invading pathogens, phagocytes such as macrophages constantly impose restrictions on pathogens’ access to their preferred carbon source, glucose. Surprisingly, it has been reported that ...
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#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Kok Lian Ho (UPM: Universiti Putra Malaysia)H-Index: 11
Last.Leslie Than Thian Lung (UPM: Universiti Putra Malaysia)H-Index: 6
view all 7 authors...
The human fungal pathogen Candida glabrata appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathogen of glucose, and therefore alternative carbon sources probably support the growth and survival of engulfed C. glabrata. The present study aimed to investigate the role of the glyoxylate cycle gene ICL1 in alternative carbon utilisation a...
5 CitationsSource
#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Kok Lian Ho (UPM: Universiti Putra Malaysia)H-Index: 11
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 6 authors...
Flexibility in carbon metabolism is pivotal for the survival and propagation of many human fungal pathogens within host niches. Indeed, flexible carbon assimilation enhances pathogenicity and affects the immunogenicity of Candida albicans. Over the last decade, Candida glabrata has emerged as one of the most common and problematic causes of invasive candidiasis. Despite this, the links between carbon metabolism, fitness, and pathogenicity in C. glabrata are largely unexplored. Therefore, this st...
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#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
Vulvovaginal candidosis (VVC) is a common gynaecological disorder that is delineated by the inflammation of vaginal wall and it is caused by the opportunistic fungal pathogen Candida species. In fact, three out of every four women will experience at least one occasion of VVC during some point in their lives. Although uncomplicated VVC is relatively harmless, the complicated VVC such as recurrent attack often creates restlessness and depression in the patients, thus greatly affects their quality ...
15 CitationsSource
#1Tzu Shan Ng (UPM: Universiti Putra Malaysia)H-Index: 3
#2Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 7 authors...
Candida glabrata is an emerging human fungal pathogen that has efficacious nutrient sensing and responsiveness ability. It can be seen through its ability to thrive in diverse range of nutrient limited-human anatomical sites. Therefore, nutrient sensing particularly glucose sensing is thought to be crucial in contributing to the development and fitness of the pathogen. This study aimed to elucidate the role of SNF3 (Sucrose Non Fermenting 3) as a glucose sensor and its possible role in contribut...
4 CitationsSource
#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Yoke Kqueen Cheah (UPM: Universiti Putra Malaysia)H-Index: 21
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 5 authors...
A conspicuous new concept of pathogens living as the microbial societies in the human host rather than free planktonic cells has raised considerable concerns among scientists and clinicians. Fungal biofilms are communities of cells that possess distinct characteristic such as increased resistance to the immune defence and antimycotic agents in comparison to their planktonic cells counterpart. Therefore, inhibition of the biofilm may represent a new paradigm for antifungal development. In this st...
15 CitationsSource
#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Yoke Kqueen Cheah (UPM: Universiti Putra Malaysia)H-Index: 21
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 5 authors...
Aims: This study investigates the antagonistic effects of the probiotic strains Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 against vulvovaginal candidiasis (VVC)-causing Candida glabrata. Methods and Results: Growth inhibitory activities of Lact. rhamnosus GR-1 and Lact. reuteri RC-14 strains against C. glabrata were demonstrated using a spot overlay assay and a plate-based microtitre assay. In addition, these probiotic lactobacilli strains also exhibited potent candidacidal ac...
31 CitationsSource
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