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Moon-Moo Kim
Dong-eui University
68Publications
20H-index
1,627Citations
Publications 68
Newest
#1Sojeong Jeon (Dong-eui University)
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Abstract Background Despite of the most effective surgical removal of malignant tumors, metastasis makes cancer treatment difficult. The studies on natural compounds to inhibit this metastasis have been actively performed until now. However, the effect of tomatidine on metastasis remains unclear. Method The effect of tomatidine on antioxidative activity was measured with DPPH radical assay and reducing power assay. After treatment with tomatidine, the viability of human fibrosarcoma cells (HT108...
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#1Hyeju Ko (Dong-eui University)
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
The purpose of this study is to investigate the effect of H2O2 on the aging of melanogenesis in human melanocytes. The staining of SA-β-galactosidase, an aging marker, was remarkably increased in the cells aged with H2O2 at 62.5 µM or more compared with young cells. The intracellular H2O2 level and melanin synthesis were also reduced in both H2O2-treated cells and senescent cells compared with young cells in DCFH-DA assay. Both the senescent cells and the H2O2-treated cells showed higher express...
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Objective Amentoflavone is the main component of Selaginella tamariscina widely known as an oriental traditional medicinal stuff that has been known to have a variety of medicinal effects such as the induction of apoptosis, anti- metastasis, and anti-inflammation. However, the effect of amentoflavone on autophagy has not been reported until now. The aim of this study was to investigate whether amentoflavone has a positive effect on the induction of autophagy related to cell aging.
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#1Sugyeong Hong (Dong-eui University)H-Index: 2
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Abstract Aging study requires aging markers to measure the degree of aging process. The aging markers such as senescence associated-β-galactosidase (SA-β-gal), lipofuscin, telomere, p53 and p16 have been known in aging study until now. Therefore, we investigated the role of genes and proteins related to aging in young, senescent and H 2 O 2 -induced old cells to develop a novel aging marker involved in aging mechanism. After cellular aging was compared in young, senescent and H 2 O 2 -induced ol...
2 CitationsSource
#1Su-Gyeong Lee (Dong-eui University)H-Index: 1
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Abstract Background The insulin-like growth factor 1 (IGF-1) signaling pathway has spotlighted as a mechanism to elucidate aging associated with autophagy in recent years. Therefore, we have tried to screen an effective compound capable of inducing autophagy to delay aging process. Purpose The aim of this study is to investigate whether pachymic acid, a main compound in Poria cocos, induces autophagy in the aged cells. Methods The aging of young cells was induced by treatment with IGF-1 at 50 ng...
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#1Eun-Jeong Kwon (Dong-eui University)H-Index: 1
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Abstract Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to ...
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본 연구는 어성초의 메탄올 추출물을 이용하여 항산화 효능이 가장 좋은 fraction을 찾고, 항산화 효능을 나타내는 성분을 분석하였다. 메탄올 추출에 의한 유기 용매 별 분획에서 항산화 효과가 가장 좋은 ethyl acetate 분획물을 칼럼 크로마토그래피하여 12가지의 fraction 중 가장 높은 항산화 효과를 보인 Fr. 10을 이...
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