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Jiankui He
South University of Science and Technology of China
Single cell sequencingDNA sequencingGeneticsBioinformaticsBiology
39Publications
11H-index
526Citations
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Publications 40
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#1Yong HuH-Index: 1
Last. Jiankui He (USTC: University of Science and Technology of China)H-Index: 11
view all 18 authors...
The pseudogap, d-wave superconductivity and electron-boson coupling are three intertwined key ingredients in the phase diagram of the cuprates. Sr_2rO_4is a 5d-electron counterpart of the cuprates in which both the pseudogap and a d-wave instability have been observed. Here, we report spectroscopic evidence for the presence of the third key player in electron-doped Sr_2rO_4 electron-boson coupling. A kink in nodal dispersion is observed with an energy scale of ~50 meV. The strength o...
1 CitationsSource
#1Muyun Peng (CSU: Central South University)
#2Yuancai Xie (PKU: Peking University)H-Index: 1
Last. Geng Tian (SZU: Shenzhen University)H-Index: 1
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BACKGROUND: Early detection of lung cancer to allow curative treatment remains challenging. Cell-free circulating tumor DNA (ctDNA) analysis may aid in malignancy assessment and early cancer diagnosis of lung nodules found in screening imagery. METHODS: The multi-center clinical study enrolled 192 patients with operable occupying lung diseases. Plasma ctDNA, white blood cell genomic DNA (gDNA) and tumor tissue gDNA of each patient were analyzed by ultra-deep sequencing to an average of 35,000X o...
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#1Yuancai Xie (PKU: Peking University)H-Index: 1
#2Fenglei Yu (CSU: Central South University)H-Index: 1
Last. Geng TianH-Index: 1
view all 19 authors...
e24036Background: Cell-free circulating tumor DNA (ctDNA) for cancer detection drew significant clinical attention. Concordance of mutations in tumor tissue and ctDNA should be evaluated first. Met...
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#1Jiankui He (Stanford University)H-Index: 11
#2HC MaurerH-Index: 1
Last. Kenneth P. Olive (CUMC: Columbia University Medical Center)H-Index: 21
view all 15 authors...
Bulk tumor tissues comprise intermixed populations of neoplastic cells and multiple stromal cell lineages. We used laser capture microdissection and RNA sequencing to disentangle the transcriptional programs active in the malignant epithelium and stroma of pancreatic ductal adenocarcinoma (PDA). This led to the development of a new algorithm (ADVOCATE) that accurately predicts the compartment fractions of bulk tumor samples and can computationally purify bulk gene expression data from PDA. We al...
1 CitationsSource
#1Deng Luo (SUSTech: South University of Science and Technology of China)
#2Meng Zhang (SUSTech: South University of Science and Technology of China)H-Index: 3
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 13 authors...
The longest possible haplotype is chromosome haplotype that is a set of co-inherited alleles occurred on a single strand chromosome inherited from one parent. Standard whole-genome shotgun sequencing technologies are limited by the inability to independently study the haplotype of homologous chromosomes due to the short-reads sequencing strategy and disturbance of homologue chromosomes. Here, we investigated several types of chromosomal abnormalities by a dilution-based method to separate an int...
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#1Luyang ZhaoH-Index: 1
#2Liwei DengH-Index: 1
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 20 authors...
Next generation sequencing (NGS) has revolutionized life sciences research. However, GC bias and costly, time-intensive library preparation make NGS an ill fit for increasing sequencing demands in the clinic. A new class of third-generation sequencing platforms has arrived to meet this need, capable of directly measuring DNA and RNA sequences at the single-molecule level without amplification. Here, we use the new GenoCare single-molecule sequencing platform from Direct Genomics to sequence the ...
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#1Ligang Xia (JNU: Jinan University)H-Index: 2
#2Zhoufang Li (SUSTech: South University of Science and Technology of China)H-Index: 5
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 15 authors...
Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker in clinical diagnostics, particularly in cancer. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics. This study examined the background somatic mutations in white blood cells (WBC) and cfDNA in healthy controls based on sequencing data from 821 non-cancer individuals and several cancer samples with the aim of understanding the patter...
12 CitationsSource
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 8 authors...
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#2Xiang LiH-Index: 58
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 9 authors...
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#1Minyue Dong (ZJU: Zhejiang University)
#2Liwei DengH-Index: 1
Last. Jiankui He (SUSTech: South University of Science and Technology of China)H-Index: 11
view all 15 authors...
The demand of non-invasive prenatal testing for autosomal aneuploidy using cell-free fetal DNA (cffDNA) in maternal plasma is a highly sought-after diagnostic, with a rapidly growing market. Current approaches developed by next generation sequencing (NGS) need PCR amplifcation during sample preparation, which results in amplification bias in GC-rich areas of the human genome. With these approaches, the minimum fetal fraction in maternal plasma is 4% for the small differences in circulating cfDNA...
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