Sara Jane Webb
University of Washington
Publications 78
Biomarker development is currently a high priority in neurodevelopmental disorder research. For many types of biomarkers (particularly biomarkers of diagnosis), reliability over short time periods is critically important. In the field of autism spectrum disorder (ASD), resting electroencephalography (EEG) power spectral densities (PSD) are well-studied for their potential as biomarkers. Classically, such data have been decomposed into pre-specified frequency bands (e.g., delta, theta, alpha, bet...
#1Nicole M. McDonald (Semel Institute for Neuroscience and Human Behavior)H-Index: 5
#2Damla Senturk (UCLA: University of California, Los Angeles)H-Index: 16
Last.Shafali S. Jeste (Semel Institute for Neuroscience and Human Behavior)H-Index: 21
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Importance Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with different genetic etiologies. Prospective examination of familial-risk infants informs understanding of developmental trajectories preceding ASD diagnosis, potentially improving early detection. Objective To compare outcomes and trajectories associated with varying familial risk for ASD across the first 3 years of life. Design, Setting, and Participants This longitudinal, prospective cohort study used data...
#1Emily NeuhausH-Index: 13
#2Sara Jane WebbH-Index: 31
Last.Raphael BernierH-Index: 44
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#1David G. AmaralH-Index: 106
#2George M. Anderson (Yale University)H-Index: 68
Last.Andrew J. O. WhitehouseH-Index: 37
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#1Tessel Bazelmans ('KCL': King's College London)H-Index: 1
#2Emily J.H. Jones (Birkbeck, University of London)H-Index: 25
Last.Sara Jane Webb (Seattle Children's Research Institute)H-Index: 31
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Interest in autonomic arousal in autism spectrum disorder (ASD) is increasing; however, reliability of these measures in ASD is unknown, and previously reported associations with social and cognitive abilities are inconsistent. This study assesses heart rate (HR) and HR variability (HRV) in preschoolers with ASD or typical development (TD) while they passively watched naturalistic videos. Measurement reliability, group differences, and the relationship with social and cognitive abilities were ev...
2 CitationsSource
The objective of the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is to evaluate a set of lab-based behavioral video tracking (VT), electroencephalogram (EEG), and eye-tracking (ET) measures for use in clinical trials with children with Autism Spectrum Disorder (ASD). Within the larger organizational structure of the ABC-CT, the Data Acquisition and Analytic Core (DAAC) oversees the standardization of VT, EEG, and ET data acquisition, data processing, and data analysis. This include...
1 CitationsSource
#1Sandra Naumann (Humboldt University of Berlin)H-Index: 1
#2Ulrike Senftleben (TUD: Dresden University of Technology)H-Index: 1
Last.Sara Jane Webb (UW: University of Washington)H-Index: 31
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Face processing has been found to be impaired in autism spectrum disorders (ASD). One hypothesis is that individuals with ASD engage in piecemeal compared to holistic face processing strategies. To investigate the role of possible impairments in holistic face processing in individuals with autism, the current study investigated behavioral and electroencephalography (EEG) correlates of face processing (P1/N170 and gamma-band activity) in adolescents with ASD and sex-, age-, and IQ-matched neuroty...
2 CitationsSource
#1Anne B. Arnett (UW: University of Washington)H-Index: 10
#2Caitlin M. Hudac (UW: University of Washington)H-Index: 12
Last.Sara Jane Webb (UW: University of Washington)H-Index: 31
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Abstract Background Autism spectrum disorder (ASD) is associated with language impairment as well as atypical auditory sensory processing. The current study investigated associations among auditory perception, implicit language learning and receptive language ability in youth with ASD. Methods We measured auditory event related potentials (ERP) during an artificial language statistical learning task in 76 youth with ASD and 27 neurotypical (NT) controls. Participants with ASD had a broad range o...
#1Emily Neuhaus (Seattle Children's Research Institute)H-Index: 13
#2Raphael Bernier (UW: University of Washington)H-Index: 44
Last.Sara Jane Webb (Seattle Children's Research Institute)H-Index: 31
view all 4 authors...
Individuals with autism spectrum disorder (ASD) are at heightened risk of psychiatric comorbidities across the lifespan, including elevated rates of internalizing, externalizing, and self-injurious behaviors. Identification of medical comorbidities that contribute to these concerns may elucidate mechanisms through which psychiatric concerns arise, as well as offer additional avenues for intervention. Gastrointestinal (GI) conditions are of particular interest, as they are prevalent among those w...
2 CitationsSource