David R. Nelson
University of Tennessee Health Science Center
Publications 549
#1Elizabeth Flood-Grady (UF: University of Florida)H-Index: 2
#2Jiawei Liu (JNU: Jinan University)
Last.Janice L. KriegerH-Index: 8
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Abstract Introduction Health research registries have great potential to increase awareness of research opportunities among diverse patient populations and reduce disparities in clinical trial accrual. However, little research has focused on patients’ intentions to participate in clinical trials once they are enrolled in the registry and their intentions to remain in the registry over time. Methods Patients (N = 312) enrolled in a university-based health research registry (i.e., Consent2Share) i...
The prokaryotic phylum Cyanobacteria are some of the oldest known photosynthetic organisms responsible for the oxygenation of the earth. Cyanobacterial species have been recognised as a prosperous source of bioactive secondary metabolites with antibacterial, antiviral, antifungal and/or anticancer activities. Cytochrome P450 monooxygenases (CYPs/P450s) contribute to the production and diversity of various secondary metabolites. To better understand the metabolic potential of cyanobacterial speci...
#1Zhenhua Liu (Norwich Research Park)
#2Hernando G. Suarez Duran (WUR: Wageningen University and Research Centre)H-Index: 2
Last.Anne Osbourn (Norwich Research Park)H-Index: 54
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#1Anna S.F. Lok (UM: University of Michigan)H-Index: 44
#2Anna S. Lok (UM: University of Michigan)H-Index: 86
Last.David R. Nelson (UF: University of Florida)H-Index: 89
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Abstract Background/Aims Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 weeks of G/P, with or without ribavirin, in patients with HCV genotype 1 infection with treatment failure after sofosbuvir and an NS5A inhibitor. Methods We performed a phas...
2 CitationsSource
#1Joseph L. Humble (University of Stirling)H-Index: 2
#2Greta Carmona-Antoñanzas (University of Stirling)H-Index: 8
Last.Armin Sturm (University of Stirling)H-Index: 26
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Background The salmon louse (Lepeophtheirus salmonis) infests farmed and wild salmonid fishes, causing considerable economic damage to the salmon farming industry. Infestations of farmed salmon are controlled using a combination of non-medicinal approaches and veterinary drug treatments. While L. salmonis has developed resistance to most available salmon delousing agents, relatively little is known about the molecular mechanisms involved. Members of the cytochrome P450 (CYP) superfamily are typi...
#1Louisa Moshoeshoe Senate (Central University of Technology)H-Index: 1
#2Martin Phalane Tjatji (Central University of Technology)H-Index: 1
Last.Khajamohiddin Syed (University of Zululand)H-Index: 3
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Cytochrome P450 monooxygenases (P450s) found in all domains of life are known for their catalytic versatility and stereo- and regio-specific activity. While the impact of lifestyle on P450 evolution was reported in many eukaryotes, this remains to be addressed in bacteria. In this report, Streptomyces and Mycobacterium, belonging to the phylum Actinobacteria, were studied owing to their contrasting lifestyles and impacts on human. Analyses of all P450s and those predicted to be associated with s...
4 CitationsSource
#1Donna M. Evon (UNC: University of North Carolina at Chapel Hill)H-Index: 18
#2Souvik Sarkar (UC Davis: University of California, Davis)H-Index: 8
Last.Michael Fried (UNC: University of North Carolina at Chapel Hill)H-Index: 81
view all 15 authors...
#1Marina Serper (UPenn: University of Pennsylvania)H-Index: 14
#2Donna M. Evon (UNC: University of North Carolina at Chapel Hill)H-Index: 18
Last.Nancy Reau (Rush University)H-Index: 16
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Background The prevalence and risk factors for non-adherence to direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) in clinical practice settings are under-studied.
#1Kavita Radhakrishnan (UCSF: University of California, San Francisco)H-Index: 11
#2Adrian M. Di Bisceglie (SLU: Saint Louis University)H-Index: 80
Last.Norah A. Terrault (SC: University of Southern California)H-Index: 67
view all 14 authors...
#1Rosa E. Cardoza (University of León)H-Index: 19
#2Susan P. McCormick (NCAUR: National Center for Agricultural Utilization Research)H-Index: 39
Last.Santiago Gutiérrez (University of León)H-Index: 36
view all 8 authors...
Trichothecenes are sesquiterpene toxins produced by diverse fungi, including some species of Trichoderma that are potential plant disease biocontrol agents. Trichoderma arundinaceum produces the trichothecene harzianum A (HA), which consists of the core trichothecene structure (12,13-epoxytrichothec-9-ene, EPT) with a linear polyketide-derived substituent (octa-2,4,6-trienedioyl) esterified to an oxygen at carbon atom 4. The genes required for biosynthesis of EPT and the eight-carbon polyketide ...
1 CitationsSource