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Francesco Prattichizzo
Marche Polytechnic University
39Publications
17H-index
653Citations
Publications 39
Newest
#1Lucia La SalaH-Index: 15
#2Simona Mrakic-Sposta (National Research Council)H-Index: 22
Last.Antonio CerielloH-Index: 76
view all 12 authors...
Background Impaired glucose tolerance (IGT) is a risk factor for the development of diabetes and related complications that ensue. Early identification of at-risk individuals might be beneficial to reduce or delay the progression of diabetes and its related complications. Recently, microRNAs emerged as potential biomarkers of diseases. The aim of the present study was to evaluate microRNA-21 as a potential biomarker for the risk of developing diabetes in adults with IGT and to investigate its do...
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#2Angelica Giuliani (Marche Polytechnic University)H-Index: 8
Last.Antonio CerielloH-Index: 76
view all 9 authors...
ABSTRACTParabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such eff...
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#1Laura Teodori (ENEA)H-Index: 21
Last.Maria Cristina Albertini (University of Urbino)H-Index: 22
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Abstract Human gut microbiota, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, may be associated with inflammation and age-related chronic health conditions. However, the mechanism underlying this association is only recently beginning to emerge. Transfer and modulation of gene expression by diet-derived microRNAs (miRs) in mammals might be involved in this communication. Through a bioinformatics approach, using on line tools and repo...
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#1Angelica Giuliani (Marche Polytechnic University)H-Index: 8
Last.Maria Rita Rippo (Marche Polytechnic University)H-Index: 25
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Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade inflammation that accompanies the whole trajectory of the disease, from its inception to complication development. Accumulating evidence is disclosing a long list of possible "triggers" of inflammatory responses, many of which are promoted by unhealthy lifestyle choices and advanced age. Diabetic patients show an altered number and function of immune cells, of both innate and acquired immunity. Reactive autoanti...
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#1Laura Del CocoH-Index: 11
#2Daniele VergaraH-Index: 20
Last.Anna Maria GiudettiH-Index: 18
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Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia associated with alterations in carbohydrate, lipid, and protein metabolism. The prognosis of T2DM patients is highly dependent on the development of complications, and therefore the identification of biomarkers of T2DM progression, with minimally invasive techniques, is a huge need. In the present study, we applied a 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomic approach coupled with multiva...
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#1Daniele Fraternale (University of Urbino)H-Index: 19
#2Laura Teodori (ENEA)H-Index: 21
Last.Maria Cristina Albertini (University of Urbino)H-Index: 22
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Abstract The use of herbs with medicinal value and biomedical effects has increased tremendously in the last years. However, inadequate basic knowledge of their mode of action is the main issue related to phytotherapy, although they have shown promising potential. To provide insights into these important issues, we tested here on appropriate in vitro models the efficacy of Angelica archangelica essential oil (Aa-EO) for anti-inflammatory properties. The results demonstrated that Aa-EO induced si...
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#1Lucia La SalaH-Index: 15
#2Simona Mrakic-Sposta (National Research Council)H-Index: 22
Last.Antonio CerielloH-Index: 76
view all 5 authors...
Background Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still poorly understood. Recently, microRNA-21 has been associated with diabetes, although its function remains unclear. We sought to explore the mechanism underlying defective SOD2 antioxidant response in HUV...
4 CitationsSource
#2Angelica Giuliani (Marche Polytechnic University)H-Index: 8
Last.Antonio CerielloH-Index: 76
view all 10 authors...
Abstract Metformin is the first-choice therapy to lower glycaemia and manage type 2 diabetes. Continuously emerging epidemiological data and experimental models are showing additional protective effects of metformin against a number of age-related diseases (ARDs), e.g., cardiovascular diseases and cancer. This evidence has prompted the design of a specific trial, i.e., the Targeting Aging with Metformin (TAME) trial, to test metformin as an anti-ageing molecule. However, a unifying or prevailing...
5 CitationsSource
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