Andrew C. Steer
University of Melbourne
ImmunologyHeart diseaseRheumatic feverScabiesMedicine
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Publications 230
#1Laila F IbrahimH-Index: 4
#2Shidan Tosif (University of Melbourne)H-Index: 4
Last. Penelope A. BryantH-Index: 17
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OBJECTIVE: International studies describing COVID-19 in children have shown low proportions of paediatric cases and generally a mild clinical course. We aimed to present early data on children tested for SARS-CoV-2 at a large Australian tertiary children's hospital according to the state health department guidelines, which varied over time. METHODS: We conducted a retrospective cohort study at The Royal Children's Hospital, Melbourne, Australia. It included all paediatric patients (aged 0-18 yea...
#2L. C. FullerH-Index: 1
Last. Roderick J. Hay ('KCL': King's College London)H-Index: 56
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Scabies is one of the most common disorders identified in any estimate of global skin disease prevalence. Furthermore, quantifying its impact on individuals and societies has been problematic. There has been a lack of clear case definitions and laboratory tests. There have been few epidemiological studies, particularly those focusing on low-income countries, variation in prevalence within high-income countries, or estimates of the effect of scabies on health beyond the skin, such as renal diseas...
#1Alexia L. Weeks (UWA: University of Western Australia)H-Index: 1
#2Heather D'Antoine (CDU: Charles Darwin University)H-Index: 19
Last. Lesley-Ann Gray (University of Cambridge)
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Whole exome sequencing (WES) is a popular and successful technology which is widely used in both research and clinical settings. However, there is a paucity of reference data for Aboriginal Australians to underpin the translation of health-based genomic research. Here we provide a catalogue of variants called after sequencing the exomes of 50 Aboriginal individuals from the Northern Territory (NT) of Australia and compare these to 72 previously published exomes from a Western Australian (WA) pop...
#1Patricia T. Campbell (University of Melbourne)H-Index: 6
#2Steven Y. C. Tong (CDU: Charles Darwin University)H-Index: 29
Last. Andrew C. Steer (University of Melbourne)H-Index: 40
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Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tis...
#1Rachel C Heenan (Royal Children's Hospital)H-Index: 2
#2Tom Parks (University of Oxford)H-Index: 9
Last. Andrew C. Steer (Royal Children's Hospital)H-Index: 40
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BACKGROUND: Rheumatic heart disease (RHD) is a chronic valvular heart disease that is responsible for a heavy burden of premature mortality in low- and middle-income countries. The total costs of RHD are important to health policy and research investment decisions. We estimate for the first time the total cost of RHD for Fiji (2008-2012) using a cost-of-illness approach and novel primary data on RHD disease burden and costs. METHODS: RHD cases were identified using probabilistic record linkage a...
#1Myra Hardy (University of Melbourne)H-Index: 2
#2Josaia Samuela (Southwest University of Visual Arts)H-Index: 3
Last. Leanne J. Robinson (Burnet Institute)H-Index: 20
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Lymphatic filariasis has remained endemic in Fiji despite repeated mass drug administration using the well-established and safe combination of diethylcarbamazine and albendazole (DA) since 2002. In certain settings the addition of ivermectin to this combination (IDA) remains a safe strategy and is more efficacious. However, the safety has yet to be described in scabies and soil-transmitted helminth endemic settings like Fiji. Villages of Rotuma and Gau islands were randomised to either DA or IDA...
#1Hannah R. C. Frost (ULB: Université libre de Bruxelles)H-Index: 4
#2Mark R. Davies (University of Melbourne)H-Index: 22
Last. Anne Botteaux (ULB: Université libre de Bruxelles)H-Index: 8
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Abstract Objectives PCR-based typing of the emm gene Streptococcus pyogenes often results in the amplification of multiple bands. This has resulted in the misclassification of strains into types based on non-emm gene sequences. We aimed to improve the specificity of the emm typing PCR reaction using a primer called CDC3, the sequence for which has been previously used to identify emm genes in silico. Methods The proposed primer CDC3 was validated in silico from a global database of 1688 GAS geno...
#1Elise Thielemans (Royal Children's Hospital)
Last. Jim ButteryH-Index: 28
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BACKGROUND: Invasive group A streptococcal disease is a severe infection with a high case fatality rate, estimated to cause more than 150,000 deaths per year worldwide. The clinical presentation of this infection is variable, and early diagnosis can be challenging. There are few data on its short- and longer-term outcomes, especially in children. The aim of this study was to assess the clinical presentation, management and short- and longer-term outcomes of invasive group A streptococcal disease...
#1Daniel Engelman (University of Melbourne)H-Index: 13
#2J. YoshizumiH-Index: 1
Last. Asha C. Bowen (UWA: University of Western Australia)H-Index: 12
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BACKGROUND: Scabies is a common parasitic skin condition that causes considerable morbidity globally. Clinical and epidemiological research for scabies have been limited by a lack of standardisation of diagnostic methods. OBJECTIVES: We aimed to develop consensus criteria for the diagnosis of common scabies that could be implemented in a variety of settings. METHODS: Consensus diagnostic criteria were developed through a Delphi study of international experts. Detailed recommendations were collec...
1 CitationsSource
#1Hannah R. C. FrostH-Index: 4
#2Mark R. DaviesH-Index: 22
Last. Pierre R. SmeestersH-Index: 22
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The core Mga (multiple gene activator) regulon of group A Streptococcus (GAS) contains genes encoding proteins involved in adhesion and immune evasion. While all GAS genomes contain genes for Mga and C5a peptidase, the intervening genes encoding M and M-like proteins vary between strains. The genetic make-up of the Mga regulon of GAS was characterized by utilizing a collection of 1,688 GAS genomes that are representative of the global GAS population. Sequence variations were examined with multip...
1 CitationsSource