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Frédéric Van Gool
University of California, San Francisco
25Publications
12H-index
1,139Citations
Publications 25
Newest
Published on Apr 1, 2019in The Journal of Allergy and Clinical Immunology
Daniel Eriksson4
Estimated H-index: 4
(KI: Karolinska Institutet),
Rosa Bacchetta44
Estimated H-index: 44
(Stanford University)
+ 16 AuthorsChristina Lundqvist5
Estimated H-index: 5
(University of Gothenburg)
Published on May 20, 2019in bioRxiv
Daniel R. Holohan1
Estimated H-index: 1
(UCSF: University of California, San Francisco),
Daniel R. Holohan (UCSF: University of California, San Francisco)+ 0 AuthorsJeffrey A. Bluestone132
Estimated H-index: 132
(UCSF: University of California, San Francisco)
Abstract Regulatory T cells (Tregs) are an immunosuppressive population that are identified based on the stable expression of the fate-determining transcription factor forkhead box P3 (Foxp3). Tregs can be divided into distinct subsets based on whether they developed in the thymus (tTregs) or in the periphery (pTregs). Whether there are unique functional roles that distinguish pTregs and tTregs remains largely unclear. To elucidate these functions, efforts have been made to specifically identify...
Published on May 1, 2019in Cell Metabolism22.41
Peter Thompson11
Estimated H-index: 11
(UCSF: University of California, San Francisco),
Ajit Shah2
Estimated H-index: 2
(UCSF: University of California, San Francisco)
+ 3 AuthorsAnil Bhushan3
Estimated H-index: 3
(UCSF: University of California, San Francisco)
Summary Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell destruction drives the disease, but whether beta cells actively participate in the pathogenesis remains unclear. Here, we show that during the natural history of T1D in humans and the non-obese diabetic (NOD) mouse model, a subset of beta cells acquires a senescence-associated secretory phenotype (SASP). Senescent beta ce...
Published on Feb 1, 2019in Immunity21.52
Frédéric Van Gool12
Estimated H-index: 12
(UCSF: University of California, San Francisco),
Michelle Nguyen5
Estimated H-index: 5
(UCSF: University of California, San Francisco)
+ 11 AuthorsMark S. Anderson37
Estimated H-index: 37
(UCSF: University of California, San Francisco)
Summary Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. We identified an IPEX (immune dysregulation polyendocrinopathy enteropathy X-linked) syndrome patient with a FOXP3 mutation in the domain swap interface of the protein. Recapitulation of this Foxp3 variant in mice led to the development of an autoimmune syndrome consistent with an unrestrained T helper type 2 (Th2) i...
Published on Jul 1, 2018in Nature43.07
Dimitre R. Simeonov12
Estimated H-index: 12
,
Benjamin G. Gowen7
Estimated H-index: 7
(University of California, Berkeley)
+ 35 AuthorsAlice Y. Chan11
Estimated H-index: 11
(UCSF: University of California, San Francisco)
In this Letter, analysis of steady-state regulatory T (Treg) cell percentages from Il2ra enhancer deletion (EDEL) and wild-type (WT) mice revealed no differences between them (Extended Data Fig. 9d). This analysis included two mice whose genotypes were incorrectly assigned. Even after correction of the genotypes, no significant differences in Treg cell percentages were seen when data across experimental cohorts were averaged (as was done in Extended Data Fig. 9d). However, if we normalize the co...
Published on Jun 1, 2018in Cell Reports7.82
David Wang43
Estimated H-index: 43
(UCSF: University of California, San Francisco),
Jason Quiros3
Estimated H-index: 3
(UCSF: University of California, San Francisco)
+ 12 AuthorsMassimiliano Pagani18
Estimated H-index: 18
(University of Milan)
Summary Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tregs) by exploiting their dependency on the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) in tumors. Disruption of EZH2 activity in Tregs, either pharmacologically or geneti...
Published on Sep 1, 2017in Nature43.07
Dimitre R. Simeonov12
Estimated H-index: 12
,
Benjamin G. Gowen7
Estimated H-index: 7
+ 35 AuthorsAlice Y. Chan11
Estimated H-index: 11
The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.
Published on Dec 5, 2016in bioRxiv
Dimitre R. Simeonov12
Estimated H-index: 12
(UCSF: University of California, San Francisco),
Benjamin G. Gowen7
Estimated H-index: 7
(University of California, Berkeley)
+ 22 AuthorsJonathan M. Woo8
Estimated H-index: 8
(UCSF: University of California, San Francisco)
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell type-specific transcriptional programs and responses to specific extracellular cues1-3. In order to understand the mechanisms by which non-coding genetic variation contributes to disease, systematic mapping of functional enhancers and their biological contexts is required. Here, we develop an unbiased discovery platform that can identify enhancers for a target gene without...
Published on Jul 1, 2015in Immunity21.52
Ari B. Molofsky17
Estimated H-index: 17
(UCSF: University of California, San Francisco),
Frédéric Van Gool12
Estimated H-index: 12
(UCSF: University of California, San Francisco)
+ 5 AuthorsRichard M. Locksley89
Estimated H-index: 89
(UCSF: University of California, San Francisco)
Summary Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced by helminth infection but also sustain metabolic homeostasis in adipose tissue and contribute to tissue repair during injury. Here we show that interleukin-33 (IL-33) mediates activation of ILC2s and Treg cells in resting adipose tissue, but also after helminth infection or treatment with IL-2. Unexpectedly, ILC2-intrinsic IL-33 activation was required for Treg cell accumulation in vivo and was i...
Published on Dec 4, 2014in Blood16.56
Frédéric Van Gool12
Estimated H-index: 12
,
Ari B. Molofsky17
Estimated H-index: 17
(UCSF: University of California, San Francisco)
+ 5 AuthorsJeffrey A. Bluestone132
Estimated H-index: 132
Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases. However, patients receiving IL-2 treatment also experience eosinophilia due to an unknown mechanism. Here, we show that patients receiving low-dose IL-2 have elevated levels of serum IL-5, and this correlates with their degree of eosinophilia. In mice, low-dose IL-2–anti-IL-2 antibody complexes drove group 2 innate lymphoid cells (ILC2) to produ...
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