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Frédéric Van Gool
University of California, San Francisco
26Publications
12H-index
1,241Citations
Publications 20
Newest
#1Daniel Eriksson (KI: Karolinska Institutet)H-Index: 4
#2Rosa Bacchetta (Stanford University)H-Index: 45
Last.Nils Landegren (KI: Karolinska Institutet)H-Index: 6
view all 19 authors...
Source
#1Peter J. Thompson (UCSF: University of California, San Francisco)H-Index: 11
#2Ajit Shah (UCSF: University of California, San Francisco)H-Index: 2
Last.Anil Bhushan (UCSF: University of California, San Francisco)H-Index: 4
view all 6 authors...
Summary Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell destruction drives the disease, but whether beta cells actively participate in the pathogenesis remains unclear. Here, we show that during the natural history of T1D in humans and the non-obese diabetic (NOD) mouse model, a subset of beta cells acquires a senescence-associated secretory phenotype (SASP). Senescent beta ce...
10 CitationsSource
#1Frédéric Van Gool (UCSF: University of California, San Francisco)H-Index: 12
#2Michelle L. Nguyen (UCSF: University of California, San Francisco)H-Index: 6
Last.Jeffrey A. Bluestone (UCSF: University of California, San Francisco)H-Index: 137
view all 14 authors...
Summary Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. We identified an IPEX (immune dysregulation polyendocrinopathy enteropathy X-linked) syndrome patient with a FOXP3 mutation in the domain swap interface of the protein. Recapitulation of this Foxp3 variant in mice led to the development of an autoimmune syndrome consistent with an unrestrained T helper type 2 (Th2) i...
4 CitationsSource
#1Dimitre R. SimeonovH-Index: 13
#2Benjamin G. Gowen (University of California, Berkeley)H-Index: 7
Last.Alexander MarsonH-Index: 20
view all 38 authors...
In this Letter, analysis of steady-state regulatory T (Treg) cell percentages from Il2ra enhancer deletion (EDEL) and wild-type (WT) mice revealed no differences between them (Extended Data Fig. 9d). This analysis included two mice whose genotypes were incorrectly assigned. Even after correction of the genotypes, no significant differences in Treg cell percentages were seen when data across experimental cohorts were averaged (as was done in Extended Data Fig. 9d). However, if we normalize the co...
Source
#1David Wang (UCSF: University of California, San Francisco)H-Index: 46
#2Jason Quiros (UCSF: University of California, San Francisco)H-Index: 3
Last.Michel DuPageH-Index: 11
view all 15 authors...
Summary Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tregs) by exploiting their dependency on the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) in tumors. Disruption of EZH2 activity in Tregs, either pharmacologically or geneti...
24 CitationsSource
#1Dimitre R. SimeonovH-Index: 13
#2Benjamin G. GowenH-Index: 7
Last.Alexander MarsonH-Index: 20
view all 38 authors...
The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.
67 CitationsSource
#1Dimitre R. Simeonov (UCSF: University of California, San Francisco)H-Index: 13
#2Benjamin G. Gowen (University of California, Berkeley)H-Index: 7
Last.Alexander Marson (UCSF: University of California, San Francisco)H-Index: 20
view all 25 authors...
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell type-specific transcriptional programs and responses to specific extracellular cues1-3. In order to understand the mechanisms by which non-coding genetic variation contributes to disease, systematic mapping of functional enhancers and their biological contexts is required. Here, we develop an unbiased discovery platform that can identify enhancers for a target gene without...
4 CitationsSource
#1Ari B. Molofsky (UCSF: University of California, San Francisco)H-Index: 18
#2Frédéric Van Gool (UCSF: University of California, San Francisco)H-Index: 12
Last.Richard M. Locksley (UCSF: University of California, San Francisco)H-Index: 95
view all 8 authors...
Summary Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced by helminth infection but also sustain metabolic homeostasis in adipose tissue and contribute to tissue repair during injury. Here we show that interleukin-33 (IL-33) mediates activation of ILC2s and Treg cells in resting adipose tissue, but also after helminth infection or treatment with IL-2. Unexpectedly, ILC2-intrinsic IL-33 activation was required for Treg cell accumulation in vivo and was i...
175 CitationsSource
#1Frédéric Van GoolH-Index: 12
#2Ari B. Molofsky (UCSF: University of California, San Francisco)H-Index: 18
Last.Jeffrey A. BluestoneH-Index: 137
view all 8 authors...
Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases. However, patients receiving IL-2 treatment also experience eosinophilia due to an unknown mechanism. Here, we show that patients receiving low-dose IL-2 have elevated levels of serum IL-5, and this correlates with their degree of eosinophilia. In mice, low-dose IL-2–anti-IL-2 antibody complexes drove group 2 innate lymphoid cells (ILC2) to produ...
44 CitationsSource
#1Benjamin Bondue (ULB: Université libre de Bruxelles)H-Index: 11
#2Olivier Vosters (ULB: Université libre de Bruxelles)H-Index: 11
Last.Marc Parmentier (ULB: Université libre de Bruxelles)H-Index: 59
view all 11 authors...
Viral diseases of the respiratory tract, which include influenza pandemic, children acute bronchiolitis, and viral pneumonia of the elderly, represent major health problems. Plasmacytoid dendritic cells play an important role in anti-viral immunity, and these cells were recently shown to express ChemR23, the receptor for the chemoattractant protein chemerin, which is expressed by epithelial cells in the lung. Our aim was to determine the role played by the chemerin/ChemR23 system in the physiopa...
49 CitationsSource
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